Marie Barro

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Laetitia LengeléYves RollandLaurent MartinezSophie GuyonnetAngelo PariniAlexandre LucasBruno VellasPhilipe de Souto BarretoSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristelle SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Casdiovasculaires Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Faculté d’Odontologie [Toulouse] Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Pôle Gériatrie [CHU Toulouse] Equipe Vieillissement (CERPOP) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Laboratoire Eau Environnement et Systèmes Urbains IUT - Sénart Fontainebleau, 36 Rue Georges Charpak, 77567 Lieusaint Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Université Paris Descartes - École de sages-femmes Baudelocque Institut de Recherche sur les CERamiques Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) University of Washington [Seattle] Centre de recherche de l'Institut universitaire de gériatrie de Montreal Centre de recherche de l'Institut universitaire de gériatrie de Montreal Bordeaux population health Bordeaux population health Faculté d’Odontologie [Toulouse] Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe EQUITY (CERPOP) Equipe EQUITY (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe MAINTAIN
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : Abstract Background Weight and appetite regulation have been associated with the expression and secretion of ATPase inhibitory factor 1 (IF1) and growth differentiation factor-15 (GDF-15), 2 potential biomarkers for age-related mitochondrial dysfunction. The aim was to explore the associations between these biomarkers and nutritional variables in the Multidomain Alzheimer Preventive Trial study. Methods IF1 and GDF-15 plasma levels were quantified at 1-year follow-up. The nutritional status was measured using the Mini Nutritional Assessment (MNA) score variation between baseline and 1- and 2-year visits; appetite loss was extracted from the MNA. Bodyweight was measured every 6 months until the third year and then yearly until the fifth year of follow-up, and weight loss was established if the loss was greater than 5% or 10% within the past 6 or 12 months, respectively. Bidirectional associations of IF1 and GDF-15 levels with malnutrition, appetite, and weight loss were examined. The interactions between individual IF1 and GDF-15 with sex were explored. Results Four hundred and forty-eight participants had MNA data and 1 045 had weight loss data. All the associations between IF1 levels and the MNA score, appetite loss, and weight loss were nonsignificant. Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over 4 years. Interactions between IF1 and GDF-15 levels, and between these 2 markers and sex were not significantly associated with the outcomes. Conclusions GDF-15 plasma levels were related to key malnutrition criteria.

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• Type de publi. : Article dans une revue
• Date de publi. : 23/10/2023
• Auteurs : Julien DelrieuBruno VellasSophie GuyonnetChristelle CantetVitaliy OvodYan LiJames BollingerRandall BatemanSandrine AndrieuIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesNicola Coley
• Organismes : Faculté d’Odontologie [Toulouse] Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe MAINTAIN Institut universitaire de France Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe MAINTAIN Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe MAINTAIN Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe MAINTAIN Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province Departments of Chemistry and Biochemistry Washington University School of Medicine [Saint Louis, MO] Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe MAINTAIN Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Pôle Gériatrie [CHU Toulouse] Equipe MAINTAIN Laboratoire Eau Environnement et Systèmes Urbains IUT - Sénart Fontainebleau, 36 Rue Georges Charpak, 77567 Lieusaint Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe MAINTAIN Université Paris Descartes - École de sages-femmes Baudelocque Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe MAINTAIN Institut de Recherche sur les CERamiques Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe MAINTAIN Centre de recherche de l'Institut universitaire de gériatrie de Montreal Centre de recherche de l'Institut universitaire de gériatrie de Montreal Bordeaux population health Bordeaux population health Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe MAINTAIN
• Publié dans Alzheimer's Research and Therapy le 23/10/2020

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Résumé : Abstract Background In MAPT (Multidomain Alzheimer Preventive Trial), a cognitive effect of multidomain intervention (MI) was showed in non-demented subjects with positive amyloid PET. However, screening eligible patients for multidomain intervention by PET is difficult to generalize in real-world settings. Methods MAPT study was a 3-year, randomized, placebo-controlled trial followed by a 2-year observational and optional extension. All participants were non-demented and randomly assigned (1:1:1:1) to the MI plus omega 3, MI plus placebo, omega 3 alone, or placebo alone group. The objectives were to assess the cognitive effect of MAPT interventions (omega 3 supplementation, MI, combined intervention) in non-demented subjects according to amyloid blood status at 12, 36, and 60 months. In this subgroup analysis (n = 483), amyloid status was defined by plasma Aβ42/40 ratio (cutoff ≤ 0.0107). The primary outcome measure was the change in cognitive composite score after a 1, 3, and 5-year clinical follow-up. Results The intention-to-treat (ITT) population included 483 subjects (161 positive and 322 negative amyloid participants based on plasma Aβ42/40 ratio). In the positive amyloid ITT population, we showed a positive effect of MI plus omega 3 on the change in composite cognitive score in 12 (raw p = .0350, 0.01917, 95% CI = [0.0136 to 0.3699]) and 36 months (raw p = .0357, 0.2818, 95% CI = [0.0190 to 0.5446]). After correction of multiple comparisons and adjustments, these differences were not significant (adjusted p = .1144 and .0690). In the per-protocol positive amyloid group (n = 154), we observed a significant difference between the combined intervention and placebo groups at 12 (p = .0313, 0.2424, 0.0571 to 0.4276) and 36 months (p = .0195, 0.3747, 0.1055 to 0.6439) persisting after adjustment. In the ITT and per-protocol analyses, no cognitive effect was observed in the positive and negative amyloid group at 60-month visit. Conclusions These findings suggest a benefit of MI plus omega 3 in positive blood amyloid subjects. This promising trend needs to be confirmed before using blood biomarkers for screening in preventive trials. Trial registration ClinicalTrials.gov Identifier: NCT01513252.

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Fichiers liés : 1-s2.0-S0378378223001330-main.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/08/2023
• Auteurs : A. BarroKizkitza InsaustiMoise KomboloMarie-Pierre Ellies-OuryJean-François Hocquette
• Organismes : State University of Londrina = Universidade Estadual de Londrina Public University of Navarre, Faculty of Education Bordeaux Sciences Agro [Gradignan] Unité Mixte de Recherche sur les Herbivores - UMR 1213 Unité Mixte de Recherche sur les Herbivores - UMR 1213 Bordeaux Sciences Agro [Gradignan] Unité Mixte de Recherche sur les Herbivores - UMR 1213

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• Type de publi. : Article dans une revue
• Date de publi. : 26/05/2023
• Auteurs : Geetika AggarwalJohn E MorleyBruno VellasAndrew D NguyenAndrew A ButlerSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Washington University School of Medicine [Saint Louis, MO] International Centre for Radio Astronomy Research Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Faculté d’Odontologie [Toulouse] Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Pôle Gériatrie [CHU Toulouse] Equipe Vieillissement (CERPOP) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Laboratoire Eau Environnement et Systèmes Urbains IUT - Sénart Fontainebleau, 36 Rue Georges Charpak, 77567 Lieusaint Université Paris Descartes - École de sages-femmes Baudelocque Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Institut de Recherche sur les CERamiques Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse University of Washington [Seattle] Centre de recherche de l'Institut universitaire de gériatrie de Montreal Centre de recherche de l'Institut universitaire de gériatrie de Montreal Bordeaux population health Bordeaux population health École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique Laboratoire de génie des procédés - environnement - agroalimentaire Optimisation - Système - Energie Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand CHU Dijon Service de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD) Cabinet médical [Dijon] Faculté d’Odontologie [Toulouse] Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe EQUITY (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe EQUITY (CERPOP) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP)
• Publié dans GeroScience le 30/10/2020

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Résumé : Abstract The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA and proteomic risk indicators for dementia. Here we report that plasma adropin concentrations predict risk for cognitive decline in the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n = 452). Cognitive ability was evaluated using a composite cognitive score (CCS) that assessed four domains: memory, language, executive function, and orientation. Relationships between plasma adropin concentrations and changes in CCS (∆CCS) were examined using Cox Proportional Hazards Regression, or by grouping into tertiles ranked low to high by adropin values and controlling for age, time between baseline and final visits, baseline CCS, and other risk factors (e.g., education, medication, APOE4 status). Risk of cognitive decline (defined as a ∆CCS of − 0.3 or more) decreased with increasing plasma adropin concentrations (hazard ratio = 0.873, 95% CI 0.780–0.977, P = 0.018). Between adropin tertiles, ∆CCS was significantly different ( P = 0.01; estimated marginal mean ± SE for the 1st to 3rd tertile, − 0.317 ± 0.064; − 0.275 ± 0.063; − 0.042 ± 0.071; n = 133,146, and 130, respectively; P < 0.05 for 1st vs. 2nd and 3rd adropin tertiles). Normalized plasma Aß 42/40 ratio and plasma neurofilament light chain, indicators of neurodegeneration, were significantly different between adropin tertile. These differences were consistent with reduced risk of cognitive decline with higher plasma adropin levels. Overall, these results suggest cognitive decline is reduced in community-dwelling older adults with higher circulating adropin levels. Further studies are needed to determine the underlying causes of the relationship and whether increasing adropin levels can delay cognitive decline.

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Fichiers liés : s11357-023-00824-3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 24/05/2023
• Auteurs : Arnaud PagèsNadège CostaMichaël MouniéPhilippe CestacPhilipe de Souto BarretoYves RollandBruno VellasLaurent MolinierBlandine Juillard-CondatBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie-Noëlle CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Centre d'Epidémiologie et de Recherche en santé des POPulations Institut universitaire de France Equipe EQUITY (CERPOP) Equipe EQUITY (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe EQUITY (CERPOP) Equipe BIOETHICS (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP)
• Publié dans Drugs and Aging le 01/11/2020

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Résumé : Introduction Potentially inappropriate medication prescribing (PIP) among older patients is associated with an increased risk of adverse events and hospitalization, and sometimes increased healthcare costs. Objective The aim of this study was to explore the association between healthcare costs and PIP exposure among older patients. Methods Analyses were conducted using data from the Multidomain Alzheimer Preventive Trial (MAPT). A computer algorithm was constructed to detect PIP based on various different explicit criteria-based tools, and the results were expressed in number of medication-related potential non-compliances (MRNCs). A prescription was considered potentially inappropriate if there were one or more MRNCs. We performed a cost analysis from the French National Health Insurance perspective, and also performed a multivariate analysis to identify the association between healthcare costs and PIP (number of MRNCs). Results The computer algorithm analyzed medication prescribing from included patients (N = 1525 aged 75.3 ± 4.4 years; 64% women [n = 978]). PIP was associated with increased total healthcare costs and non-medication healthcare costs after adjusting for potential confounders. We also noted that healthcare costs tended to increase with the number of MRNCs. The mean additional healthcare costs were €517, €921, and €1669 per patient and year for patients with one or two MRNCs, three or four MRNCs, and five or more MRNCs, respectively, in comparison with patients with appropriate medication prescriptions. Conclusion These observations led us to conclude that interventions focused on reducing PIP could result in savings.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2023
• Auteurs : Kelly GiudiciPhilipe de Souto BarretoSophie GuyonnetJohn MorleyAndrew D NguyenGeetika AggarwalAngelo PariniYan LiRandall John BatemanBruno VellasBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola ColeySherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCarole DufouilMichèle AllardMichèle AllardMarie Noëlle-CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonFrédéric RicolfiLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronDominique DuboisFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarie Paule Bonceour MartelJacques MonteilMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolFrançois CottonAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysAlain BonaféMichel ZancaPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierStéphane ChanaletJacques DarcourtYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesFrançoise HugonStéphane LehéricyMarie ChupinJean-François ManginAli Bouhayia
• Organismes : Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Institut des Maladies Métaboliques et Casdiovasculaires Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Equipe Vieillissement (CERPOP)
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. This study aimed to investigate the associations between biomarkers of neurodegeneration, nutrition, and inflammation among community-dwelling older adults, and to verify if associations differed according to apolipoprotein E (APOE) ε4 status. This cross-sectional analysis included 475 participants ≥70 years old from the Multidomain Alzheimer Preventive Trial (MAPT), mean age 76.8 years (SD = 4.5), 59.4% women. Biomarkers of neurodegeneration (plasma amyloid-β 42/40—Aβ 42/40, neurofilament light chain—NfL, progranulin), nutrition (erythrocyte docosahexaenoic acid, eicosapentaenoic acid, omega-3 index; plasma homocysteine—Hcy, 25 hydroxyvitamin D), inflammation (plasma tumor necrosis factor receptor 1—TNFR-1, monocyte chemoattractant protein 1—MCP-1, interleukin 6—IL-6), and cellular stress (plasma growth differentiation factor 15—GDF-15) were assessed. Linear regression analyses were performed to investigate the associations between nutritional and inflammatory biomarkers (independent variables) and neurodegenerative biomarkers (dependent variables), with adjustments for age, sex, education, body mass index, physical activity, allocation to MAPT groups, and APOE ε4 status. After adjusting for confounders, Aβ 42/40 was not associated with nutritional or inflammatory markers. NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy. Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1. Analyses restricted to APOE ε4 carriers (n = 116; 26.9%) or noncarriers were mostly similar. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Casey PapovichJustin W. ColeGuang YangSteven L. FinkelsteinGuillermo BarroVéronique BuatDenis BurgarellaPablo G. Pérez-GonzálezPaola SantiniLise-Marie SeilléLu ShenPablo Arrabal HaroMicaela B. BagleyEric F. BellLaura BisigelloAntonello CalabròCaitlin M. CaseyMarco CastellanoKatherine ChworowskyNikko J. CleriLuca CostantinM. C. CooperMark DickinsonHenry C. FergusonAdriano FontanaMauro GiavaliscoAndrea GrazianNorman A. GroginNimish P. HathiBenne W. HolwerdaTaylor A. HutchisonJeyhan S. KartaltepeLisa J. KewleyAllison KirkpatrickDale D. KocevskiAnton M. KoekemoerRebecca L. LarsonArianna S. LongRay A. LucasLaura PentericciNor PirzkalSwara RavindranathRachel S. SomervilleJonathan R. TrumpStephanie M. Urbano StawinskiBenjamin J. WeinerStephen M. WilkinsL. Y. Aaron YungJorge A. Zavala
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille
• Publié dans The Astrophysical journal letters le 28/10/2020

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Résumé : We present results from the Cosmic Evolution Early Release Survey on the stellar population parameters for 28 galaxies with redshifts 4 < z < 9 using imaging data from the James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) combined with data from the Hubble Space Telescope and the Spitzer Space Telescope. The JWST/MIRI 5.6 and 7.7 μm data extend the coverage of the rest-frame spectral energy distribution to nearly 1 μm for galaxies in this redshift range. By modeling the galaxies' SEDs the MIRI data show that the galaxies have, on average, rest-frame UV (1600 Å)-I-band colors 0.4 mag bluer than derived when using photometry that lacks MIRI. Therefore, the galaxies have lower ratios of stellar mass to light. The MIRI data reduce the stellar masses by $\langle {\rm{\Delta }}\mathrm{log}{M}_{* }\rangle =0.25$ dex at 4 < z < 6 and 0.37 dex at 6 < z < 9. This also reduces the star formation rates (SFRs) by <ΔlogSFR> = 0.14 dex at 4 < z < 6 and 0.27 dex at 6 < z < 9. The MIRI data also improve constraints on the allowable stellar mass formed in early star formation. We model this using a star formation history that includes both a "burst" at z _f = 100 and a slowly varying ("delayed-τ") model. The MIRI data reduce the allowable stellar mass by 0.6 dex at 4 < z < 6 and by ≈1 dex at 6 < z < 9. Applying these results globally, this reduces the cosmic stellar-mass density by an order of magnitude in the early Universe (z ≈ 9). Therefore, observations of rest-frame ≳1 μm are paramount for constraining the stellar-mass buildup in galaxies at very high redshifts.

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Fichiers liés : Papovich_2023_ApJL_949_L18.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Luca CostantinPablo G Pérez-GonzálezYuchen GuoChiara ButtittaShardha JogeeMicaela B BagleyGuillermo BarroJeyhan S KartaltepeAnton M KoekemoerCristina CabelloEnrico Maria CorsiniJairo Méndez-AbreuAlexander de la VegaKartheik G IyerLaura BisigelloYingjie ChengLorenzo MorelliPablo Arrabal HaroFernando BuitragoM.C CooperAvishai DekelMark DickinsonSteven L FinkelsteinMauro GiavaliscoBenne W HolwerdaMarc Huertas-CompanyRay A LucasCasey PapovichNor PirzkalLise-Marie SeilléJesús Vega-FerreroStijn WuytsL.Y. Aaron Yung
• Organismes : Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille
• Publié dans Nature le 29/10/2020

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Résumé : The majority of massive disk galaxies in the local Universe show a stellar barred structure in their central regions, including our Milky Way. Bars are supposed to develop in dynamically cold stellar disks at low redshift, as the strong gas turbulence typical of disk galaxies at high redshift suppresses or delays bar formation. Moreover, simulations predict bars to be almost absent beyond $z = 1.5$ in the progenitors of Milky Way-like galaxies. Here we report observations of ceers-2112, a barred spiral galaxy at redshift $z_{\rm phot} \sim 3$, which was already mature when the Universe was only 2 Gyr old. The stellar mass ($M_{\star} = 3.9 \times 10^9 M_{\odot}$) and barred morphology mean that ceers-2112 can be considered a progenitor of the Milky Way, in terms of both structure and mass-assembly history in the first 2 Gyr of the Universe, and was the closest in mass in the first 4 Gyr. We infer that baryons in galaxies could have already dominated over dark matter at $z \sim 3$, that high-redshift bars could form in approximately 400 Myr and that dynamically cold stellar disks could have been in place by redshift $z = 4-5$ (more than 12 Gyrs ago).

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Fichiers liés : s41586-023-06636-x.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Jorge A. ZavalaVéronique BuatCaitlin M. CaseySteven L. FinkelsteinDenis BurgarellaMicaela B. BagleyLaure CieslaEmanuele DaddiMark DickinsonHenry C. FergusonMaximilien FrancoE. F. Jiménez-AndradeJeyhan S. KartaltepeAnton M. KoekemoerAurélien Le BailE. J. MurphyCasey PapovichSandro TacchellaStephen M. WilkinsItziar AretxagaPeter BehrooziJaclyn B. ChampagneAdriano FontanaMauro GiavaliscoAndrea GrazianNorman A. GroginLisa J. KewleyDale D. KocevskiAllison KirkpatrickJennifer M. LotzLaura PentericciPablo G. Pérez-GonzálezNor PirzkalSwara RavindranathRachel S. SomervilleJonathan R. TrumpGuang YangL. Y. Aaron YungOmar AlmainiRicardo O. AmorínMarianna AnnunziatellaPablo Arrabal HaroBren E. BackhausGuillermo BarroEric F. BellRachana BhatawdekarLaura BisigelloFernando BuitragoAntonello CalabròMarco CastellanoÓscar A. Chávez OrtizKatherine ChworowskyNikko J. CleriSeth H. CohenJustin W. ColeKevin C. CookeM. C. CooperAsantha R. CoorayLuca CostantinIsabella G. CoxDarren CrotonRomeel DavéAlexander de La VegaAvishai DekelDavid ElbazVicente Estrada-CarpenterVital FernándezKeely D. FinkelsteinJonathan FreundlichSeiji FujimotoÁngela García-ArgumánezJonathan P. GardnerEric GawiserCarlos Gómez-GuijarroYuchen GuoTimothy S. HamiltonNimish P. HathiBenne W. HolwerdaMichaela HirschmannMarc Huertas-CompanyTaylor A. HutchisonKartheik G. IyerAnne E. JaskotSaurabh W. JhaShardha JogeeStéphanie JuneauIntae JungSusan A. KassinPeter KurczynskiRebecca L. LarsonGene C. K. LeungArianna S. LongRay A. LucasBenjamin MagnelliKameswara Bharadwaj ManthaJasleen MatharuElizabeth J. McgrathDaniel H. McintoshAubrey MedranoEmiliano MerlinBahram MobasherAlexa M. MoralesJeffrey A. NewmanDavid C. NichollsViraj PandyaMarc RafelskiKaila RonayneCaitlin RoseRussell E. RyanPaola SantiniLise-Marie SeilléEkta A. ShahLu ShenRaymond C. SimonsGregory F. SnyderElizabeth R. StanwayAmber N. StraughnHarry I. TeplitzBrittany N. VanderhoofJesús Vega-FerreroWeichen WangBenjamin J. WeinerChristopher N. A. WillmerStijn Wuyts
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Observatoire astronomique de Strasbourg Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Laboratoire d'Astrophysique de Marseille
• Publié dans The Astrophysical journal letters le 28/10/2020

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Résumé : Lyman-break galaxy (LBG) candidates at z ≳ 10 are rapidly being identified in James Webb Space Telescope (JWST)/NIRCam observations. Due to the (redshifted) break produced by neutral hydrogen absorption of rest-frame UV photons, these sources are expected to drop out in the bluer filters while being well detected in redder filters. However, here we show that dust-enshrouded star-forming galaxies at lower redshifts (z ≲ 7) may also mimic the near-infrared (near-IR) colors of z > 10 LBGs, representing potential contaminants in LBG candidate samples. First, we analyze CEERS-DSFG-1, a NIRCam dropout undetected in the F115W and F150W filters but detected at longer wavelengths. Combining the JWST data with (sub)millimeter constraints, including deep NOEMA interferometric observations, we show that this source is a dusty star-forming galaxy (DSFG) at z ≈ 5.1. We also present a tentative 2.6σ SCUBA-2 detection at 850 μm around a recently identified z ≈ 16 LBG candidate in the same field and show that, if the emission is real and associated with this candidate, the available photometry is consistent with a z ~ 5 dusty galaxy with strong nebular emission lines despite its blue near-IR colors. Further observations on this candidate are imperative to mitigate the low confidence of this tentative submillimeter emission and its positional uncertainty. Our analysis shows that robust (sub)millimeter detections of NIRCam dropout galaxies likely imply z ~ 4-6 redshift solutions, where the observed near-IR break would be the result of a strong rest-frame optical Balmer break combined with high dust attenuation and strong nebular line emission, rather than the rest-frame UV Lyman break. This provides evidence that DSFGs may contaminate searches for ultra-high redshift LBG candidates from JWST observations.

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Fichiers liés : Zavala_2023_ApJL_943_L9.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Hollis B. AkinsCaitlin M. CaseyNatalie AllenMicaela B. BagleyMark DickinsonSteven L. FinkelsteinMaximilien FrancoSantosh HarishPablo Arrabal HaroOlivier IlbertJeyhan S. KartaltepeAnton M. KoekemoerDaizhong LiuArianna S. LongHenry Joy MccrackenLouise PaquereauCasey PapovichNor PirzkalJason RhodesBrant E. RobertsonMarko ShuntovSune ToftGuang YangGuillermo BarroLaura BisigelloVéronique BuatJaclyn B. ChampagneOlivia CooperLuca CostantinAlexander de La VegaNicole E. DrakosAndreas FaisstAdriano FontanaSeiji FujimotoSteven GillmanCarlos Gómez-GuijarroGhassem GozaliaslNimish P. HathiChristopher C. HaywardMichaela HirschmannBenne W. HolwerdaShuowen JinDale D. KocevskiVasily KokorevErini LambridesRay A. LucasGeorgios E. MagdisBenjamin MagnelliJed MckinneyBahram MobasherPablo G. Pérez-GonzálezR. Michael RichLise-Marie SeilléMargherita TaliaC. Megan UrryFrancesco ValentinoKatherine E. WhitakerL. Y. Aaron YungJorge Zavala
• Organismes : Laboratoire d'Astrophysique de Marseille Institut d'Astrophysique de Paris Institut d'Astrophysique de Paris Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille
• Publié dans The Astrophysical Journal le 05/07/2023

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Résumé : We present a search for extremely red, dust-obscured, z > 7 galaxies with JWST/NIRCam+MIRI imaging over the first 20 arcmin² of publicly available Cycle 1 data from the COSMOS-Web, CEERS, and PRIMER surveys. Based on their red color in F277W-F444W (~2.5 mag) and detection in MIRI/F770W (~25 mag), we identify two galaxies, COS-z8M1 and CEERS-z7M1, that have best-fit photometric redshifts of $z={8.4}_{-0.4}^{+0.3}$ and ${7.6}_{-0.1}^{+0.1}$ , respectively. We perform spectral energy distribution fitting with a variety of codes (including BAGPIPES, PROSPECTOR, BEAGLE, and CIGALE) and find a >95% probability that these indeed lie at z > 7. Both sources are compact (R _eff ≲ 200 pc) and highly obscured (A _V ~ 1.5-2.5) and, at our best-fit redshift estimates, likely have strong [O III]+Hβ emission contributing to their 4.4 μm photometry. We estimate stellar masses of ~10¹⁰ M _⊙ for both sources; by virtue of detection in MIRI at 7.7 μm, these measurements are robust to the inclusion of bright emission lines, for example, from an active galactic nucleus. We identify a marginal (2.9σ) Atacama Large Millimeter/submillimeter Array detection at 2 mm within 0.″5 of COS-z8M1, which, if real, would suggest a remarkably high IR luminosity of ~10¹² L _⊙. These two galaxies, if confirmed at z ~ 8, would be extreme in their stellar and dust masses and may be representative of a substantial population of highly dust-obscured galaxies at cosmic dawn.

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Fichiers liés : Akins_2023_ApJ_956_61.pdf

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