Marie Barro

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/08/2023
• Auteurs : A. BarroKizkitza InsaustiMoise KomboloMarie-Pierre Ellies-OuryJean-François Hocquette
• Organismes : State University of Londrina = Universidade Estadual de Londrina Public University of Navarre, Faculty of Education Bordeaux Sciences Agro [Gradignan] Unité Mixte de Recherche sur les Herbivores - UMR 1213 Unité Mixte de Recherche sur les Herbivores - UMR 1213 Bordeaux Sciences Agro [Gradignan] Unité Mixte de Recherche sur les Herbivores - UMR 1213

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• Type de publi. : Article dans une revue
• Date de publi. : 24/05/2023
• Auteurs : Arnaud PagèsNadège CostaMichaël MouniéPhilippe CestacPhilipe de Souto BarretoYves RollandBruno VellasLaurent MolinierBlandine Juillard-CondatBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie-Noëlle CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Centre d'Epidémiologie et de Recherche en santé des POPulations Centre d'Epidémiologie et de Recherche en santé des POPulations Centre d'Epidémiologie et de Recherche en santé des POPulations Centre d'Epidémiologie et de Recherche en santé des POPulations Centre d'Epidémiologie et de Recherche en santé des POPulations Centre d'Epidémiologie et de Recherche en santé des POPulations Centre d'Epidémiologie et de Recherche en santé des POPulations Centre d'Epidémiologie et de Recherche en santé des POPulations Centre d'Epidémiologie et de Recherche en santé des POPulations
• Publié dans Drugs and Aging le 01/11/2020

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Résumé : Introduction Potentially inappropriate medication prescribing (PIP) among older patients is associated with an increased risk of adverse events and hospitalization, and sometimes increased healthcare costs. Objective The aim of this study was to explore the association between healthcare costs and PIP exposure among older patients. Methods Analyses were conducted using data from the Multidomain Alzheimer Preventive Trial (MAPT). A computer algorithm was constructed to detect PIP based on various different explicit criteria-based tools, and the results were expressed in number of medication-related potential non-compliances (MRNCs). A prescription was considered potentially inappropriate if there were one or more MRNCs. We performed a cost analysis from the French National Health Insurance perspective, and also performed a multivariate analysis to identify the association between healthcare costs and PIP (number of MRNCs). Results The computer algorithm analyzed medication prescribing from included patients (N = 1525 aged 75.3 ± 4.4 years; 64% women [n = 978]). PIP was associated with increased total healthcare costs and non-medication healthcare costs after adjusting for potential confounders. We also noted that healthcare costs tended to increase with the number of MRNCs. The mean additional healthcare costs were €517, €921, and €1669 per patient and year for patients with one or two MRNCs, three or four MRNCs, and five or more MRNCs, respectively, in comparison with patients with appropriate medication prescriptions. Conclusion These observations led us to conclude that interventions focused on reducing PIP could result in savings.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Jorge A. ZavalaVéronique BuatCaitlin M. CaseySteven L. FinkelsteinDenis BurgarellaMicaela B. BagleyLaure CieslaEmanuele DaddiMark DickinsonHenry C. FergusonMaximilien FrancoE. F. Jiménez-AndradeJeyhan S. KartaltepeAnton M. KoekemoerAurélien Le BailE. J. MurphyCasey PapovichSandro TacchellaStephen M. WilkinsItziar AretxagaPeter BehrooziJaclyn B. ChampagneAdriano FontanaMauro GiavaliscoAndrea GrazianNorman A. GroginLisa J. KewleyDale D. KocevskiAllison KirkpatrickJennifer M. LotzLaura PentericciPablo G. Pérez-GonzálezNor PirzkalSwara RavindranathRachel S. SomervilleJonathan R. TrumpGuang YangL. Y. Aaron YungOmar AlmainiRicardo O. AmorínMarianna AnnunziatellaPablo Arrabal HaroBren E. BackhausGuillermo BarroEric F. BellRachana BhatawdekarLaura BisigelloFernando BuitragoAntonello CalabròMarco CastellanoÓscar A. Chávez OrtizKatherine ChworowskyNikko J. CleriSeth H. CohenJustin W. ColeKevin C. CookeM. C. CooperAsantha R. CoorayLuca CostantinIsabella G. CoxDarren CrotonRomeel DavéAlexander de La VegaAvishai DekelDavid ElbazVicente Estrada-CarpenterVital FernándezKeely D. FinkelsteinJonathan FreundlichSeiji FujimotoÁngela García-ArgumánezJonathan P. GardnerEric GawiserCarlos Gómez-GuijarroYuchen GuoTimothy S. HamiltonNimish P. HathiBenne W. HolwerdaMichaela HirschmannMarc Huertas-CompanyTaylor A. HutchisonKartheik G. IyerAnne E. JaskotSaurabh W. JhaShardha JogeeStéphanie JuneauIntae JungSusan A. KassinPeter KurczynskiRebecca L. LarsonGene C. K. LeungArianna S. LongRay A. LucasBenjamin MagnelliKameswara Bharadwaj ManthaJasleen MatharuElizabeth J. McgrathDaniel H. McintoshAubrey MedranoEmiliano MerlinBahram MobasherAlexa M. MoralesJeffrey A. NewmanDavid C. NichollsViraj PandyaMarc RafelskiKaila RonayneCaitlin RoseRussell E. RyanPaola SantiniLise-Marie SeilléEkta A. ShahLu ShenRaymond C. SimonsGregory F. SnyderElizabeth R. StanwayAmber N. StraughnHarry I. TeplitzBrittany N. VanderhoofJesús Vega-FerreroWeichen WangBenjamin J. WeinerChristopher N. A. WillmerStijn Wuyts
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Observatoire astronomique de Strasbourg Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Laboratoire d'Astrophysique de Marseille
• Publié dans The Astrophysical journal letters le 28/10/2020

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Résumé : Lyman-break galaxy (LBG) candidates at z ≳ 10 are rapidly being identified in James Webb Space Telescope (JWST)/NIRCam observations. Due to the (redshifted) break produced by neutral hydrogen absorption of rest-frame UV photons, these sources are expected to drop out in the bluer filters while being well detected in redder filters. However, here we show that dust-enshrouded star-forming galaxies at lower redshifts (z ≲ 7) may also mimic the near-infrared (near-IR) colors of z > 10 LBGs, representing potential contaminants in LBG candidate samples. First, we analyze CEERS-DSFG-1, a NIRCam dropout undetected in the F115W and F150W filters but detected at longer wavelengths. Combining the JWST data with (sub)millimeter constraints, including deep NOEMA interferometric observations, we show that this source is a dusty star-forming galaxy (DSFG) at z ≈ 5.1. We also present a tentative 2.6σ SCUBA-2 detection at 850 μm around a recently identified z ≈ 16 LBG candidate in the same field and show that, if the emission is real and associated with this candidate, the available photometry is consistent with a z ~ 5 dusty galaxy with strong nebular emission lines despite its blue near-IR colors. Further observations on this candidate are imperative to mitigate the low confidence of this tentative submillimeter emission and its positional uncertainty. Our analysis shows that robust (sub)millimeter detections of NIRCam dropout galaxies likely imply z ~ 4-6 redshift solutions, where the observed near-IR break would be the result of a strong rest-frame optical Balmer break combined with high dust attenuation and strong nebular line emission, rather than the rest-frame UV Lyman break. This provides evidence that DSFGs may contaminate searches for ultra-high redshift LBG candidates from JWST observations.

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Fichiers liés : Zavala_2023_ApJL_943_L9.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Luc Molet-BenhamouKelly Virecoulon GiudiciPhilipe de Souto BarretoChristelle CantetYves RollandBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie-Noëlle CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie-Paule Boncoeur-MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Gérontopôle Gérontopôle Gérontopôle Gérontopôle Gérontopôle Centre d'Epidémiologie et de Recherche en santé des POPulations Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Abstract Long-term use of urate-lowering therapies (ULT) may reduce inflammaging and thus prevent cognitive decline during aging. This article examined the association between long-term use of ULT and cognitive decline among community-dwelling older adults with spontaneous memory complaints. We performed a secondary observational analysis using data of 1673 participants ≥ 70 years old from the Multidomain Alzheimer Preventive Trial (MAPT Study), a randomized controlled trial assessing the effect of a multidomain intervention, the administration of polyunsaturated fatty acids (PUFA), both, or placebo on cognitive decline. We compared cognitive decline during the 5-year follow-up between three groups according to ULT (i.e. allopurinol and febuxostat) use: participants treated with ULT during at least 75% of the study period (PT ≥ 75; n = 51), less than 75% (PT < 75; n = 31), and non-treated participants (PNT; n = 1591). Cognitive function (measured by a composite score) was assessed at baseline, 6 months and every year for 5 years. Linear mixed models were performed and results were adjusted for age, sex, body mass index (BMI), diagnosis of arterial hypertension or diabetes, baseline composite cognitive score, and MAPT intervention groups. After the 5-year follow-up, only non-treated participants presented a significant decline in the cognitive composite score (mean change − 0.173, 95%CI − 0.212 to − 0.135; p < 0.0001). However, there were no differences in change of the composite cognitive score between groups (adjusted between-group difference for PT ≥ 75 vs. PNT: 0.144, 95%CI − 0.075 to 0.363, p = 0.196; PT < 75 vs. PNT: 0.103, 95%CI − 0.148 to 0.353, p = 0.421). Use of ULT was not associated with reduced cognitive decline over a 5-year follow-up among community-dwelling older adults at risk of dementia.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/08/2022
• Auteurs : Mariam BarroIssa WonniMarie SimoninAbalo Itolou KassankognoAgnieszka KlonowskaLionel MoulinGilles BénaIrénée SomdaCaroline BrunelCharlotte Tollenaere
• Organismes : Plant Health Institute of Montpellier Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Université Polytechnique Nazi Boni Bobo-Dioulasso Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Institut de Recherche en Horticulture et Semences Plant Health Institute of Montpellier Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Plant Health Institute of Montpellier Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Plant Health Institute of Montpellier Plant Health Institute of Montpellier Université Polytechnique Nazi Boni Bobo-Dioulasso Fonctionnement agroécologique et performances des systèmes de cultures horticoles Département Performances des systèmes de production et de transformation tropicaux Plant Health Institute of Montpellier
• Publié dans FEMS Microbiology Ecology le 24/10/2020

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Résumé : Due to their potential applications for food safety, there is a growing interest in rice root-associated microbial communities, but some systems remain understudied. Here, we compare the assemblage of root-associated microbiota in rice sampled in 19 small farmer's fields from irrigated and rainfed lowlands in Burkina Faso, using an amplicon metabarcoding approach of the 16S rRNA gene (prokaryotes, three plant samples per field) and ITS (fungi, one sample per field). In addition to the expected structure by root compartments (root vs rhizosphere) and geographical zones, we showed that the rice production system is a major driver of microbiome structure. In irrigated systems, we found a higher diversity of prokaryotic communities from the rhizosphere and more complex co-occurrence networks, compared to rainfed lowlands, while fungal communities exhibited an opposite pattern (higher richness in rainfed lowlands). Core taxa were different between the two systems, and indicator species were identified: mostly within Bacillaceae in rainfed lowlands, and within Burkholderiaceae and Moraxellaceae in irrigated areas. Finally, a higher abundance in rainfed lowlands was found for mycorrhizal fungi (both compartments) and rhizobia (rhizosphere only). Our results highlight deep microbiome differences induced by contrasted rice production systems that should consequently be considered for microbial engineering applications.

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• Type de publi. : Article dans une revue
• Date de publi. : 13/01/2022
• Auteurs : Alassane OuattaraFidèle TiendrébéogoNathalie BeckerCica UrbinoGaël ThébaudMurielle HoareauAgathe AllibertFrédéric ChiroleuMarie-Stéphanie VernereyEdgar Valentin TraoréNicolas BarroOumar TraoréPierre LefeuvreJean-Michel Lett
• Organismes : Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Peuplements végétaux et bioagresseurs en milieu tropical Université Joseph Ki-Zerbo [Ouagadougou] LMI Patho-Bios Institut de l'Environnement et Recherches Agricoles [Ouagadougou] LMI Patho-Bios Institut de Systématique, Evolution, Biodiversité Plant Health Institute of Montpellier Département Systèmes Biologiques Plant Health Institute of Montpellier Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Plant Health Institute of Montpellier Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Université Joseph Ki-Zerbo [Ouagadougou] Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques
• Publié dans Scientific Reports le 26/10/2020

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Résumé : In recent decades, a legion of monopartite begomoviruses transmitted by the whitefly Bemisia tabaci has emerged as serious threats to vegetable crops in Africa. Recent studies in Burkina Faso (West Africa) reported the predominance of pepper yellow vein Mali virus (PepYVMLV) and its frequent association with a previously unknown DNA-B component. To understand the role of this DNA-B component in the emergence of PepYVMLV, we assessed biological traits related to virulence, virus accumulation, location in the tissue and transmission. We demonstrate that the DNA-B component is not required for systemic movement and symptom development of PepYVMLV (non-strict association), but that its association produces more severe symptoms including growth arrest and plant death. The increased virulence is associated with a higher viral DNA accumulation in plant tissues, an increase in the number of contaminated nuclei of the phloem parenchyma and in the transmission rate by B. tabaci. Our results suggest that the association of a DNA-B component with the otherwise monopartite PepYVMLV is a key factor of its emergence.

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Fichiers liés : s41598-021-03957-7.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Steven L. FinkelsteinMicaela B. BagleyPablo Arrabal HaroMark DickinsonHenry C. FergusonJeyhan S. KartaltepeCasey PapovichDenis BurgarellaDale D. KocevskiMarc Huertas-CompanyKartheik G. IyerAnton M. KoekemoerRebecca L. LarsonPablo G. Pérez-GonzálezCaitlin RoseSandro TacchellaStephen M. WilkinsKatherine ChworowskyAubrey MedranoAlexa M. MoralesRachel S. SomervilleL. Y. Aaron YungAdriano FontanaMauro GiavaliscoAndrea GrazianNorman A. GroginLisa J. KewleyAllison KirkpatrickPeter KurczynskiJennifer M. LotzLaura PentericciNor PirzkalSwara RavindranathRussell E. RyanJonathan R. TrumpGuang YangOmar AlmainiRicardo O. AmorínMarianna AnnunziatellaBren E. BackhausGuillermo BarroPeter BehrooziEric F. BellRachana BhatawdekarLaura BisigelloVolker BrommVéronique BuatFernando BuitragoAntonello CalabròCaitlin M. CaseyMarco CastellanoÓscar A. Chávez OrtizLaure CieslaNikko J. CleriSeth H. CohenJustin W. ColeKevin C. CookeM. C. CooperAsantha R. CoorayLuca CostantinIsabella G. CoxDarren CrotonEmanuele DaddiRomeel DavéAlexander de La VegaAvishai DekelDavid ElbazVicente Estrada-CarpenterSandra M. FaberVital FernándezKeely D. FinkelsteinJonathan FreundlichSeiji FujimotoÁngela García-ArgumánezJonathan P. GardnerEric GawiserCarlos Gómez-GuijarroYuchen GuoKurt HamblinTimothy S. HamiltonNimish P. HathiBenne W. HolwerdaMichaela HirschmannTaylor A. HutchisonAnne E. JaskotSaurabh W. JhaShardha JogeeStéphanie JuneauIntae JungSusan A. KassinAurélien Le BailGene C. K. LeungRay A. LucasBenjamin MagnelliKameswara Bharadwaj ManthaJasleen MatharuElizabeth J. McgrathDaniel H. McintoshEmiliano MerlinBahram MobasherJeffrey A. NewmanDavid C. NichollsViraj PandyaMarc RafelskiKaila RonaynePaola SantiniLise-Marie SeilléEkta A. ShahLu ShenRaymond C. SimonsGregory F. SnyderElizabeth R. StanwayAmber N. StraughnHarry I. TeplitzBrittany N. VanderhoofJesús Vega-FerreroWeichen WangBenjamin J. WeinerChristopher N. A. WillmerStijn WuytsJorge A. Zavala
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Observatoire astronomique de Strasbourg Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Laboratoire d'Astrophysique de Marseille
• Publié dans The Astrophysical journal letters le 28/10/2020

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Résumé : We report the discovery of a candidate galaxy with a photo-z of z ~ 12 in the first epoch of the James Webb Space Telescope (JWST) Cosmic Evolution Early Release Science Survey. Following conservative selection criteria, we identify a source with a robust z _phot = ${11.8}_{-0.2}^{+0.3}$ (1σ uncertainty) with m _F200W = 27.3 and ≳7σ detections in five filters. The source is not detected at λ < 1.4 μm in deep imaging from both Hubble Space Telescope (HST) and JWST and has faint ~3σ detections in JWST F150W and HST F160W, which signal a Lyα break near the red edge of both filters, implying z ~ 12. This object (Maisie's Galaxy) exhibits F115W - F200W > 1.9 mag (2σ lower limit) with a blue continuum slope, resulting in 99.6% of the photo-z probability distribution function favoring z > 11. All data-quality images show no artifacts at the candidate's position, and independent analyses consistently find a strong preference for z > 11. Its colors are inconsistent with Galactic stars, and it is resolved (r _h = 340 ± 14 pc). Maisie's Galaxy has log M _*/M _⊙ ~ 8.5 and is highly star-forming (log sSFR ~ -8.2 yr^-1), with a blue rest-UV color (β ~ -2.5) indicating little dust, though not extremely low metallicity. While the presence of this source is in tension with most predictions, it agrees with empirical extrapolations assuming UV luminosity functions that smoothly decline with increasing redshift. Should follow-up spectroscopy validate this redshift, our universe was already aglow with galaxies less than 400 Myr after the Big Bang.

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Fichiers liés : Finkelstein_2022_ApJL_940_L55.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Lingxiao HeJohn MorleyGeetika AggarwalAndrew NguyenBruno VellasPhilipe de Souto BarretoSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie Noëlle-CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean‐pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinSophie PeifferAnne HitzelMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalNicola Coley
• Organismes : Centre Hospitalier Universitaire de Toulouse Saint Louis University School of Medicine [St Louis] Saint Louis University School of Medicine [St Louis] Saint Louis University Saint Louis University School of Medicine [St Louis] Saint Louis University Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Centre Hospitalier Régional Universitaire [Montpellier] Institut des Neurosciences de Montpellier
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI). Cognitive functions were measured as mini mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations. In the whole population, higher plasma NfL was cross-sectionally associated with lower cognitive functions (MMSE: β = − 0.007, 95% CI [− 0.013, − 0.001]; CCS: β = − 0.003, 95% CI [− 0.006, − 0.001]). In adults with MCI, but not NC, higher plasma NfL was associated with lower CCS at the cross-sectional level (β = − 0.003, 95% CI [− 0.005, − 0.0002]). The upper quartile NfL group further demonstrated more over time decline in CCS (β = − 0.07, 95% CI [− 0.12, − 0.01]) under the MCI status. Plasma NfL can be a promising biomarker of progressive cognition decline in older adults with MCI.

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Fichiers liés : s41598-021-91038-0.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2021
• Auteurs : Wan-Hsuan LuPhilipe de Souto BarretoYves RollandAli BouyahiaClara FischerJean-François ManginKelly GiudiciBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleStatistical AnalysisSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations CATI Multicenter Neuroimaging Platform CATI Multicenter Neuroimaging Platform Université Paris-Saclay CATI Multicenter Neuroimaging Platform Université Paris-Saclay Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : Background This study aims to investigate the predictive value of biological and neuroimaging markers to determine incident frailty among older people for a period of 5 years. Methods We included 1394 adults aged 70 years and older from the Multidomain Alzheimer Preventive Trial, who were not frail at baseline (according to Fried’s criteria) and who had at least 1 post-baseline measurement of frailty. Participants who progressed to frailty during the 5-year follow-up were categorized as “incident frailty” and those who remained non-frail were categorized as “without frailty.” The differences of baseline biochemical factors (25-hydroxyvitamin D, homocysteine, omega-3 index, C-reactive protein), other biological markers (Apolipoprotein E genotypes, amyloid-β deposits), and neuroimaging data (gray matter volume, hippocampal volume, white matter hyperintensities) were compared between groups. Cox proportional hazard model was used to evaluate the associations between biomarkers and incident frailty. Results A total of 195 participants (14.0%) became frail over 5 years. Although 25-hydroxyvitamin D deficiency, homocysteine levels, low-grade inflammation (persistently increased C-reactive protein 3–10 mg/L), gray matter, and hippocampal volume were significantly associated with incident frailty in unadjusted models, these associations disappeared after adjustment for age, sex, and other confounders. Omega-3 index was the sole marker that presented a trend of association with incident frailty (hazard ratio: 0.92; 95% confidence interval: 0.83–1.01; p = .082). Conclusions This study failed to identify biomarkers able to predict frailty incidence in community-dwelling older adults for a period of 5 years. Further longitudinal research with multiple measurements of biomarkers and frailty is needed to evaluate the long-term relationships between changes in biomarkers levels and frailty evolution.

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• Type de publi. : Article dans une revue
• Date de publi. : 13/07/2021
• Auteurs : Jérémy RaffinYves RollandGeetika AggarwalAndrew NguyenJohn MorleyYan LiRandall BatemanBruno VellasPhilipe de Souto BarretoSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyCéline CaillaudPierre-Jean OussetBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey Gabelle-DeloustalAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean‐pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinSophie PeifferAnne HitzelMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalNicola Coley
• Organismes : Institut du Vieillissement Gérontopôle Gérontopôle Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps Institut du Vieillissement Saint Louis University Saint Louis University Saint Louis University China University of Petroleum Washington University School of Medicine in St. Louis Washington University School of Medicine in St. Louis Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps Gérontopôle Institut du Vieillissement Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps Gérontopôle Institut du Vieillissement Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : Physical activity (PA) demonstrated benefits on brain health, but its relationship with blood biomarkers of neurodegeneration remains poorly investigated. We explored the cross-sectional associations of PA with blood concentrations of neurofilament light chain (NFL) and beta amyloid (Aβ)42/40. We further examined whether the interaction between PA and these biomarkers was longitudinally related to cognition. Four-hundred and sixty-five nondemented older adults engaged in an interventional study and who had a concomitant assessment of PA levels and blood measurements of NFL (pg/mL) and Aβ 42/40 were analyzed. A composite Z-score combining 4 cognitive tests was used for cognitive assessment up to a 4-year follow-up. Multiple linear regressions demonstrated that people achieving 500–999 and 2000+ MET-min/week of PA had lower (ln)NFL concentrations than their inactive peers. Logistic regressions revealed that achieving at least 90 MET-min/week of PA was associated with a lower probability of having high NFL concentrations (ie, ≥91.961 pg/mL [third quartile]). PA was not associated with (Aβ)42/40. Mixed-model linear regressions demonstrated that the reverse relationship between PA and cognitive decline tended to be more pronounced as Aβ 42/40 increased, while it was dampened with increasing levels of (ln)NFL concentrations. This study demonstrates that PA is associated with blood NFL but not with Aβ 42/40. Furthermore, it suggests that PA may attenuate the negative association between amyloid load and cognition, while having high NFL levels mitigates the favorable relationship between PA and cognition. More investigations on non demented older adults are required for further validation of the present findings.

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