Marie Barro

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• Type de publi. : Autre publication
• Date de publi. : 01/01/2025
• Auteurs : Frédérique TrevidyDominique Pougheon BertrandRémi GagnayreJacques WolfromGuillaume BRUGIDOUMarcel Le GuenJean-Paul CocotPatrick CuvilliezOussman BarroBoubacar DialloFrançoise Ngo MbangaAminata Coulibaly KoamaEva-Charlotte NiahouéNiati AbdelazizEloubnani MohcineRosales HadaGervais MélaniePetitot CécileFond-Harmant LaurencePeyronnie Marie MakdessiBonafos Antonella
• Organismes : ALFI ; Groupe Arcade Vyv ; 59 rue de Provence 75009 Paris Laboratoire Educations et Promotion de la Santé UR3412 Laboratoire Educations et Promotion de la Santé UR3412 Laboratoire Educations et Promotion de la Santé UR3412 CPH Arcade Vyv, Groupe Arcade Vyv ALFI ; Groupe Arcade Vyv ; 59 rue de Provence 75009 Paris ALFI ; Groupe Arcade Vyv ; 59 rue de Provence 75009 Paris ALFI ; Groupe Arcade Vyv ; 59 rue de Provence 75009 Paris ALFI ; Groupe Arcade Vyv ; 59 rue de Provence 75009 Paris ALFI ; Groupe Arcade Vyv ; 59 rue de Provence 75009 Paris Laboratoire Educations et Promotion de la Santé UR3412 GHU Paris Psychiatrie et Neurosciences

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Résumé : Les principes du logement d’abord sont d'attribuer directement un logement pérenne aux personnes sans domicile, et de proposer un accompagnement centré sur l'habitant. Cette recherche s’appuie sur le concept d’identité-logement (IL), prônant que l’habitant développe un rapport singulier avec son logement constitué d'habitudes, de perceptions, de projections. Cette IL se construit grâce au développement de capabilités, définies comme la capacité, et la liberté à utiliser les ressources à disposition pour choisir son propre mode de vie (Sen, 1992). Les objectifs de l'étude sont de définir une liste de capabilités liées à l'IL chez des locataires ayant connu un parcours sans domicile et d'identifier dans l'accompagnement global, des facteurs limitant ou favorisant le développement de ces capabilités. Cette recherche comprend une première phase impliquant des résidents isolés, logés au sein des pensions de famille de l’ALFI et ayant connu préalablement un parcours sans domicile. La seconde phase cible des familles monoparentales hébergées à l’hôtel et relogées dans le parc social d’Antin Résidences. La recherche est collaborative et associe des personnes concernées à toutes les étapes du protocole. Les résultats proposent une liste de 10 capabilités liées à l'identité-logement ainsi qu'un outil d'identification des facteurs permettant de convertir les ressources en capabilités. Ces facteurs sont de nature sociale, spatiale, personnelle et temporelle, et permettent de mieux orienter l'accompagnement global vers un développement de l'IL des habitants.

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Fichiers liés : fiche rehal recherche logement d'abord 2024 V3.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 04/03/2024
• Auteurs : Amanda BarroKizkitza InsaustiMoïse Kombolo NgahMarie-Pierre Ellies-OuryJean-François Hocquette
• Organismes : Unité Mixte de Recherche sur les Herbivores - UMR 1213 Bordeaux Sciences Agro [Gradignan] Unité Mixte de Recherche sur les Herbivores - UMR 1213
• Publié dans Viandes et Produits Carnés le 21/10/2020

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Fichiers liés : Vol_3936_Ontologies.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Laetitia LengeléYves RollandLaurent MartinezSophie GuyonnetAlberto PariniAlexandre LucasBruno VellasPhilipe de Souto BarretoSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristelle SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Centre Hospitalier Universitaire de Toulouse Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Faculté d’Odontologie [Toulouse] Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Laboratoire Eau Environnement et Systèmes Urbains IUT - Sénart Fontainebleau, 36 Rue Georges Charpak, 77567 Lieusaint Université Paris Descartes - École de sages-femmes Baudelocque Institut de Recherche sur les CERamiques Centre Hospitalier Universitaire de Toulouse University of Washington [Seattle] Centre de recherche de l'Institut universitaire de gériatrie de Montreal Centre de recherche de l'Institut universitaire de gériatrie de Montreal Bordeaux population health Bordeaux population health Faculté d’Odontologie [Toulouse] Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Equipe EQUITY (CERPOP) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP)
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : Abstract Background Weight and appetite regulation have been associated with the expression and secretion of ATPase inhibitory factor 1 (IF1) and growth differentiation factor-15 (GDF-15), 2 potential biomarkers for age-related mitochondrial dysfunction. The aim was to explore the associations between these biomarkers and nutritional variables in the Multidomain Alzheimer Preventive Trial study. Methods IF1 and GDF-15 plasma levels were quantified at 1-year follow-up. The nutritional status was measured using the Mini Nutritional Assessment (MNA) score variation between baseline and 1- and 2-year visits; appetite loss was extracted from the MNA. Bodyweight was measured every 6 months until the third year and then yearly until the fifth year of follow-up, and weight loss was established if the loss was greater than 5% or 10% within the past 6 or 12 months, respectively. Bidirectional associations of IF1 and GDF-15 levels with malnutrition, appetite, and weight loss were examined. The interactions between individual IF1 and GDF-15 with sex were explored. Results Four hundred and forty-eight participants had MNA data and 1 045 had weight loss data. All the associations between IF1 levels and the MNA score, appetite loss, and weight loss were nonsignificant. Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over 4 years. Interactions between IF1 and GDF-15 levels, and between these 2 markers and sex were not significantly associated with the outcomes. Conclusions GDF-15 plasma levels were related to key malnutrition criteria.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 23/10/2023
• Auteurs : Julien DelrieuBruno VellasSophie GuyonnetChristelle CantetVitaliy OvodYan LiJames BollingerRandall BatemanSandrine AndrieuIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesNicola Coley
• Organismes : Gérontopôle Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Gérontopôle Equipe Vieillissement (CERPOP) Gérontopôle Centre d'Epidémiologie et de Recherche en santé des POPulations Gérontopôle Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province Departments of Chemistry and Biochemistry Washington University School of Medicine [Saint Louis, MO] Equipe Vieillissement (CERPOP) Gérontopôle Centre Hospitalier Universitaire de Toulouse Pôle Gériatrie [CHU Toulouse] Equipe Vieillissement (CERPOP) Laboratoire Eau Environnement et Systèmes Urbains IUT - Sénart Fontainebleau, 36 Rue Georges Charpak, 77567 Lieusaint Université Paris Descartes - École de sages-femmes Baudelocque Institut de Recherche sur les CERamiques Centre Hospitalier Universitaire de Toulouse Centre de recherche de l'Institut universitaire de gériatrie de Montreal Centre de recherche de l'Institut universitaire de gériatrie de Montreal Bordeaux population health Bordeaux population health
• Publié dans Alzheimer's Research and Therapy le 23/10/2020

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Résumé : Abstract Background

In MAPT (Multidomain Alzheimer Preventive Trial), a cognitive effect of multidomain intervention (MI) was showed in non-demented subjects with positive amyloid PET. However, screening eligible patients for multidomain intervention by PET is difficult to generalize in real-world settings.

Methods

MAPT study was a 3-year, randomized, placebo-controlled trial followed by a 2-year observational and optional extension. All participants were non-demented and randomly assigned (1:1:1:1) to the MI plus omega 3, MI plus placebo, omega 3 alone, or placebo alone group. The objectives were to assess the cognitive effect of MAPT interventions (omega 3 supplementation, MI, combined intervention) in non-demented subjects according to amyloid blood status at 12, 36, and 60 months. In this subgroup analysis (n = 483), amyloid status was defined by plasma Aβ42/40 ratio (cutoff ≤ 0.0107). The primary outcome measure was the change in cognitive composite score after a 1, 3, and 5-year clinical follow-up.

Results

The intention-to-treat (ITT) population included 483 subjects (161 positive and 322 negative amyloid participants based on plasma Aβ42/40 ratio). In the positive amyloid ITT population, we showed a positive effect of MI plus omega 3 on the change in composite cognitive score in 12 (raw p = .0350, 0.01917, 95% CI = [0.0136 to 0.3699]) and 36 months (raw p = .0357, 0.2818, 95% CI = [0.0190 to 0.5446]). After correction of multiple comparisons and adjustments, these differences were not significant (adjusted p = .1144 and .0690). In the per-protocol positive amyloid group (n = 154), we observed a significant difference between the combined intervention and placebo groups at 12 (p = .0313, 0.2424, 0.0571 to 0.4276) and 36 months (p = .0195, 0.3747, 0.1055 to 0.6439) persisting after adjustment. In the ITT and per-protocol analyses, no cognitive effect was observed in the positive and negative amyloid group at 60-month visit.

Conclusions

These findings suggest a benefit of MI plus omega 3 in positive blood amyloid subjects. This promising trend needs to be confirmed before using blood biomarkers for screening in preventive trials.

Trial registration

ClinicalTrials.gov Identifier: NCT01513252.

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Fichiers liés : 1-s2.0-S0378378223001330-main.pdf

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Source

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/08/2023
• Auteurs : A. BarroKizkitza InsaustiMoise KomboloMarie-Pierre Ellies-OuryJean-François Hocquette
• Organismes : State University of Londrina = Universidade Estadual de Londrina Public University of Navarre, Faculty of Education Bordeaux Sciences Agro [Gradignan] Unité Mixte de Recherche sur les Herbivores - UMR 1213 Unité Mixte de Recherche sur les Herbivores - UMR 1213 Bordeaux Sciences Agro [Gradignan] Unité Mixte de Recherche sur les Herbivores - UMR 1213

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• Type de publi. : Article dans une revue
• Date de publi. : 26/05/2023
• Auteurs : Geetika AggarwalJohn E MorleyBruno VellasAndrew D NguyenAndrew A ButlerSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] International Centre for Radio Astronomy Research Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Faculté d’Odontologie [Toulouse] Pôle Gériatrie [CHU Toulouse] Equipe Vieillissement (CERPOP) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Laboratoire Eau Environnement et Systèmes Urbains IUT - Sénart Fontainebleau, 36 Rue Georges Charpak, 77567 Lieusaint Université Paris Descartes - École de sages-femmes Baudelocque Institut de Recherche sur les CERamiques Centre Hospitalier Universitaire de Toulouse University of Washington [Seattle] Centre de recherche de l'Institut universitaire de gériatrie de Montreal Centre de recherche de l'Institut universitaire de gériatrie de Montreal Bordeaux population health Bordeaux population health École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique Laboratoire de génie des procédés - environnement - agroalimentaire Optimisation - Système - Energie Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand CHU Dijon Service de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD) Cabinet médical [Dijon] Faculté d’Odontologie [Toulouse] Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP)
• Publié dans GeroScience le 30/10/2020

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Résumé : Abstract The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA and proteomic risk indicators for dementia. Here we report that plasma adropin concentrations predict risk for cognitive decline in the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifier, NCT00672685; mean age 75.8y, SD = 4.5 years, 60.2% female, n = 452). Cognitive ability was evaluated using a composite cognitive score (CCS) that assessed four domains: memory, language, executive function, and orientation. Relationships between plasma adropin concentrations and changes in CCS (∆CCS) were examined using Cox Proportional Hazards Regression, or by grouping into tertiles ranked low to high by adropin values and controlling for age, time between baseline and final visits, baseline CCS, and other risk factors (e.g., education, medication, APOE4 status). Risk of cognitive decline (defined as a ∆CCS of − 0.3 or more) decreased with increasing plasma adropin concentrations (hazard ratio = 0.873, 95% CI 0.780–0.977, P = 0.018). Between adropin tertiles, ∆CCS was significantly different ( P = 0.01; estimated marginal mean ± SE for the 1st to 3rd tertile, − 0.317 ± 0.064; − 0.275 ± 0.063; − 0.042 ± 0.071; n = 133,146, and 130, respectively; P < 0.05 for 1st vs. 2nd and 3rd adropin tertiles). Normalized plasma Aß 42/40 ratio and plasma neurofilament light chain, indicators of neurodegeneration, were significantly different between adropin tertile. These differences were consistent with reduced risk of cognitive decline with higher plasma adropin levels. Overall, these results suggest cognitive decline is reduced in community-dwelling older adults with higher circulating adropin levels. Further studies are needed to determine the underlying causes of the relationship and whether increasing adropin levels can delay cognitive decline.

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Fichiers liés : s11357-023-00824-3.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 24/05/2023
• Auteurs : Arnaud PagèsNadège CostaMichaël MouniéPhilippe CestacPhilipe de Souto BarretoYves RollandBruno VellasLaurent MolinierBlandine Juillard-CondatBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie-Noëlle CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Centre d'Epidémiologie et de Recherche en santé des POPulations Institut universitaire de France Equipe EQUITY (CERPOP) Equipe EQUITY (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe EQUITY (CERPOP) Equipe BIOETHICS (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP)
• Publié dans Drugs and Aging le 01/11/2020

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Résumé : Introduction Potentially inappropriate medication prescribing (PIP) among older patients is associated with an increased risk of adverse events and hospitalization, and sometimes increased healthcare costs. Objective The aim of this study was to explore the association between healthcare costs and PIP exposure among older patients. Methods Analyses were conducted using data from the Multidomain Alzheimer Preventive Trial (MAPT). A computer algorithm was constructed to detect PIP based on various different explicit criteria-based tools, and the results were expressed in number of medication-related potential non-compliances (MRNCs). A prescription was considered potentially inappropriate if there were one or more MRNCs. We performed a cost analysis from the French National Health Insurance perspective, and also performed a multivariate analysis to identify the association between healthcare costs and PIP (number of MRNCs). Results The computer algorithm analyzed medication prescribing from included patients (N = 1525 aged 75.3 ± 4.4 years; 64% women [n = 978]). PIP was associated with increased total healthcare costs and non-medication healthcare costs after adjusting for potential confounders. We also noted that healthcare costs tended to increase with the number of MRNCs. The mean additional healthcare costs were €517, €921, and €1669 per patient and year for patients with one or two MRNCs, three or four MRNCs, and five or more MRNCs, respectively, in comparison with patients with appropriate medication prescriptions. Conclusion These observations led us to conclude that interventions focused on reducing PIP could result in savings.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2023
• Auteurs : Kelly GiudiciPhilipe de Souto BarretoSophie GuyonnetJohn MorleyAndrew D NguyenGeetika AggarwalAlberto PariniYan LiRandall John BatemanBruno VellasBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola ColeySherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCarole DufouilMichèle AllardMichèle AllardMarie Noëlle-CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonFrédéric RicolfiLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronDominique DuboisFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarie Paule Bonceour MartelJacques MonteilMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolFrançois CottonAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysAlain BonaféMichel ZancaPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierStéphane ChanaletJacques DarcourtYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesFrançoise HugonStéphane LehéricyMarie ChupinJean-François ManginAli Bouhayia
• Organismes : Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Institut des Maladies Métaboliques et Casdiovasculaires Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Equipe Vieillissement (CERPOP)
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. This study aimed to investigate the associations between biomarkers of neurodegeneration, nutrition, and inflammation among community-dwelling older adults, and to verify if associations differed according to apolipoprotein E (APOE) ε4 status. This cross-sectional analysis included 475 participants ≥70 years old from the Multidomain Alzheimer Preventive Trial (MAPT), mean age 76.8 years (SD = 4.5), 59.4% women. Biomarkers of neurodegeneration (plasma amyloid-β 42/40—Aβ 42/40, neurofilament light chain—NfL, progranulin), nutrition (erythrocyte docosahexaenoic acid, eicosapentaenoic acid, omega-3 index; plasma homocysteine—Hcy, 25 hydroxyvitamin D), inflammation (plasma tumor necrosis factor receptor 1—TNFR-1, monocyte chemoattractant protein 1—MCP-1, interleukin 6—IL-6), and cellular stress (plasma growth differentiation factor 15—GDF-15) were assessed. Linear regression analyses were performed to investigate the associations between nutritional and inflammatory biomarkers (independent variables) and neurodegenerative biomarkers (dependent variables), with adjustments for age, sex, education, body mass index, physical activity, allocation to MAPT groups, and APOE ε4 status. After adjusting for confounders, Aβ 42/40 was not associated with nutritional or inflammatory markers. NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy. Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1. Analyses restricted to APOE ε4 carriers (n = 116; 26.9%) or noncarriers were mostly similar. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Casey PapovichJustin W. ColeGuang YangSteven L. FinkelsteinGuillermo BarroVéronique BuatDenis BurgarellaPablo G. Pérez-GonzálezPaola SantiniLise-Marie SeilléLu ShenPablo Arrabal HaroMicaela B. BagleyEric F. BellLaura BisigelloAntonello CalabròCaitlin M. CaseyMarco CastellanoKatherine ChworowskyNikko J. CleriLuca CostantinM. C. CooperMark DickinsonHenry C. FergusonAdriano FontanaMauro GiavaliscoAndrea GrazianNorman A. GroginNimish P. HathiBenne W. HolwerdaTaylor A. HutchisonJeyhan S. KartaltepeLisa J. KewleyAllison KirkpatrickDale D. KocevskiAnton M. KoekemoerRebecca L. LarsonArianna S. LongRay A. LucasLaura PentericciNor PirzkalSwara RavindranathRachel S. SomervilleJonathan R. TrumpStephanie M. Urbano StawinskiBenjamin J. WeinerStephen M. WilkinsL. Y. Aaron YungJorge A. Zavala
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille
• Publié dans The Astrophysical journal letters le 28/10/2020

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Résumé : We present results from the Cosmic Evolution Early Release Survey on the stellar population parameters for 28 galaxies with redshifts 4 < z < 9 using imaging data from the James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) combined with data from the Hubble Space Telescope and the Spitzer Space Telescope. The JWST/MIRI 5.6 and 7.7 μm data extend the coverage of the rest-frame spectral energy distribution to nearly 1 μm for galaxies in this redshift range. By modeling the galaxies' SEDs the MIRI data show that the galaxies have, on average, rest-frame UV (1600 Å)-I-band colors 0.4 mag bluer than derived when using photometry that lacks MIRI. Therefore, the galaxies have lower ratios of stellar mass to light. The MIRI data reduce the stellar masses by $\langle {\rm{\Delta }}\mathrm{log}{M}_{* }\rangle =0.25$ dex at 4 < z < 6 and 0.37 dex at 6 < z < 9. This also reduces the star formation rates (SFRs) by <ΔlogSFR> = 0.14 dex at 4 < z < 6 and 0.27 dex at 6 < z < 9. The MIRI data also improve constraints on the allowable stellar mass formed in early star formation. We model this using a star formation history that includes both a "burst" at z _f = 100 and a slowly varying ("delayed-τ") model. The MIRI data reduce the allowable stellar mass by 0.6 dex at 4 < z < 6 and by ≈1 dex at 6 < z < 9. Applying these results globally, this reduces the cosmic stellar-mass density by an order of magnitude in the early Universe (z ≈ 9). Therefore, observations of rest-frame ≳1 μm are paramount for constraining the stellar-mass buildup in galaxies at very high redshifts.

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Fichiers liés : Papovich_2023_ApJL_949_L18.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Luca CostantinPablo G Pérez-GonzálezYuchen GuoChiara ButtittaShardha JogeeMicaela B BagleyGuillermo BarroJeyhan S KartaltepeAnton M KoekemoerCristina CabelloEnrico Maria CorsiniJairo Méndez-AbreuAlexander de la VegaKartheik G IyerLaura BisigelloYingjie ChengLorenzo MorelliPablo Arrabal HaroFernando BuitragoM.C CooperAvishai DekelMark DickinsonSteven L FinkelsteinMauro GiavaliscoBenne W HolwerdaMarc Huertas-CompanyRay A LucasCasey PapovichNor PirzkalLise-Marie SeilléJesús Vega-FerreroStijn WuytsL.Y. Aaron Yung
• Organismes : Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille
• Publié dans Nature le 29/10/2020

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Résumé : The majority of massive disk galaxies in the local Universe show a stellar barred structure in their central regions, including our Milky Way. Bars are supposed to develop in dynamically cold stellar disks at low redshift, as the strong gas turbulence typical of disk galaxies at high redshift suppresses or delays bar formation. Moreover, simulations predict bars to be almost absent beyond $z = 1.5$ in the progenitors of Milky Way-like galaxies. Here we report observations of ceers-2112, a barred spiral galaxy at redshift $z_{\rm phot} \sim 3$, which was already mature when the Universe was only 2 Gyr old. The stellar mass ($M_{\star} = 3.9 \times 10^9 M_{\odot}$) and barred morphology mean that ceers-2112 can be considered a progenitor of the Milky Way, in terms of both structure and mass-assembly history in the first 2 Gyr of the Universe, and was the closest in mass in the first 4 Gyr. We infer that baryons in galaxies could have already dominated over dark matter at $z \sim 3$, that high-redshift bars could form in approximately 400 Myr and that dynamically cold stellar disks could have been in place by redshift $z = 4-5$ (more than 12 Gyrs ago).

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Fichiers liés : s41586-023-06636-x.pdf

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