Matthieu Chauveau

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/10/2022
• Auteurs : Matthieu ChauveauDavid CarassusMarc Ohana
• Organismes : Laboratoire de Recherche en Management (LIREM)

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Fichiers liés : presentation_AGRH_19octobre2022.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/08/2022
• Auteurs : Rihua ZengMatthieu BaudrierAnne-Catherine ChauveauMichel DesmonsGabriel FedelFrancesco GrespanPierrick HamelBryan JonesRyoichi MiyamotoDomenic NicosiaDaniel NollOlivier PiquetAlejandro SosaAnders SvenssonEmmanouil Trachanas
• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers

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Résumé : RFQ at ESS has been successfully gone through RF conditioning, RF re-conditioning and low duty cycle beam commissioning. RFQ fulfills required functions and overall performance is satisfactory. RF conditioning, three RF re-conditionings after LEBT intervention and beam commissioning will be reported and RFQ performance during these periods will be described. RFQ performance in a large extent is reflected by dynamics and interactions between RF, cavity and beam. Thanks to advanced hardware capabilities and intelligent software intelligence, observation of those dynamics and interactions are done in detailed level. Analysis of those dynamics and interaction will be introduced. Some techniques to deal with challenges resulted from those dynamics and interactions will also be discussed.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/06/2022
• Auteurs : Olivier PiquetMatthieu BaudrierAnne-Catherine ChauveauMichel DesmonsPierrick HamelBryan JonesDaniel NollAlejandro SosaEmmanouil TrachanasRihua Zeng
• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers

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Résumé : The 352.21 MHz Radio Frequency Quadrupole (RFQ) for the European Spallation Source ERIC (ESS) has been delivered by the end of 2019 by CEA/IRFU. The RFQ is designed to accelerate a 70 mA proton beam from 75 keV up to 3.62 MeV. It consists of a 4-vane resonant cavity with a total length of 4.6 m. Two coaxial power loop couplers feed the RFQ with the 1.4 MW of RF power required for beam operation. This paper first presents the main systems required for the RFQ conditioning. Then it summarizes the main steps and results of this high power RF conditioning completed at ESS from June 9 to July 29, 2021 in order to achieve the nominal field for a pulse length of 3.2ms at the repetition rate of 14Hz.

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• Type de publi. : Article dans une revue
• Date de publi. : 23/02/2022
• Auteurs : Matthieu ChourroutHugo RositiElodie OngViolaine HubertAlexandre PaccaletLouis FoucaultAwen AutretBarbara FayardCécile OlivierRadu BolbosFrançoise PeyrinClaire Crola Da SilvaDavid MeyronetOlivier RaineteauHélène ElleaumeEmmanuel BrunFabien ChauveauMarlène WiartCécile Olivier
• Organismes : Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Institut Pascal Cardiovasculaire, métabolisme, diabétologie et nutrition Cardiovasculaire, métabolisme, diabétologie et nutrition Cardiovasculaire, métabolisme, diabétologie et nutrition Institut cellule souche et cerveau / Stem Cell and Brain Research Institute Novitom [Grenoble] Novitom [Grenoble] Imagerie Tomographique et Radiothérapie Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant Imagerie Tomographique et Radiothérapie Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Université de Lyon Institut cellule souche et cerveau / Stem Cell and Brain Research Institute Synchrotron Radiation for Biomedicine = Rayonnement SynchroTROn pour la Recherche BiomédicalE Synchrotron Radiation for Biomedicine = Rayonnement SynchroTROn pour la Recherche BiomédicalE Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Cardiovasculaire, métabolisme, diabétologie et nutrition
• Publié dans Biomedical optics express le 31/10/2020

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Résumé : White-matter injury leads to severe functional loss in many neurological diseases. Myelin staining on histological samples is the most common technique to investigate white-matter fibers. However, tissue processing and sectioning may affect the reliability of 3D volumetric assessments. The purpose of this study was to propose an approach that enables myelin fibers to be mapped in the whole rodent brain with microscopic resolution and without the need for strenuous staining. With this aim, we coupled inline (propagation-based) X-ray phase-contrast tomography (XPCT) to ethanol-induced brain sample dehydration. We here provide the proof-of-concept that this approach enhances myelinated axons in rodent and human brain tissue. In addition, we demonstrated that white-matter injuries could be detected and quantified with this approach, using three animal models: ischemic stroke, premature birth and multiple sclerosis. Furthermore, in analogy to diffusion tensor imaging (DTI), we retrieved fiber directions and DTI-like diffusion metrics from our XPCT data to quantitatively characterize white-matter microstructure. Finally, we showed that this non-destructive approach was compatible with subsequent complementary brain sample analysis by conventional histology. In-line XPCT might thus become a novel gold-standard for investigating white-matter injury in the intact brain. This is Part I of a series of two articles reporting the value of in-line XPCT for virtual histology of the brain; Part II shows how in-line XPCT enables the whole-brain 3D morphometric analysis of amyloid-β (Aβ) plaques.

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Fichiers liés : boe-13-3-1620.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Marion GransagneGabriel AymeSébastien BrierGaëlle Chauveau-Le FriecVéronique MeriauxMireille NowakowskiFrançois DéjardinGuilherme Dias de MeloGuilherme Dias de MeloFlora DonatiMatthieu ProtSébastien BrûléBertrand RaynalBertrand RaynalPedro GoncalvesXavier MontagutelliJames P. Di SantoFrançoise LazariniPatrick EnglandStéphane PêtresNicolas EscriouPierre Lafaye
• Organismes : Département de Santé Globale - Department Global Health Ingénierie des Anticorps (plate-forme) - Antibody Engineering (Platform) Plateforme Technologique de RMN Biologique et HDX-MS - Biological NMR and HDX-MS Technological Platform Ingénierie des Anticorps (plate-forme) - Antibody Engineering (Platform) Ingénierie des Anticorps (plate-forme) - Antibody Engineering (Platform) Plateforme technologique Production et purification de protéines recombinantes – Production and Purification of Recombinant Proteins Technological Platform Plateforme technologique Production et purification de protéines recombinantes – Production and Purification of Recombinant Proteins Technological Platform Biologie des Infections - Biology of Infection Lyssavirus, épidémiologie et neuropathologie - Lyssavirus Epidemiology and Neuropathology Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses Biophysique Moléculaire (plateforme) - Molecular Biophysics (platform) Biophysique Moléculaire (plateforme) - Molecular Biophysics (platform) Plateforme technologique Production et purification de protéines recombinantes – Production and Purification of Recombinant Proteins Technological Platform Immunité Innée - Innate Immunity Génétique de la souris - Mouse Genetics Immunité Innée - Innate Immunity Perception et Mémoire / Perception and Memory Biophysique Moléculaire (plateforme) - Molecular Biophysics (platform) Plateforme technologique Production et purification de protéines recombinantes – Production and Purification of Recombinant Proteins Technological Platform Département de Santé Globale - Department Global Health Ingénierie des Anticorps (plate-forme) - Antibody Engineering (Platform)
• Publié dans Journal of Biological Chemistry le 02/11/2020

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Résumé : The current COVID-19 pandemic illustrates the importance of obtaining reliable methods for the rapid detection of SARS-CoV-2. A highly specific and sensitive diagnostic test able to differentiate the SARS-CoV-2 virus from common human coronaviruses is therefore needed. Coronavirus nucleoprotein (N) localizes to the cytoplasm and the nucleolus and is required for viral RNA synthesis. N is the most abundant coronavirus protein, so it is of utmost importance to develop specific antibodies for its detection. In this study, we developed a sandwich immunoassay to recognize the SARS-CoV-2 N protein. We immunized one alpaca with recombinant SARS-CoV-2 N and constructed a large single variable domain on heavy chain (VHH) antibody library. After phage display selection, seven VHHs recognizing the full N protein were identified by ELISA. These VHHs did not recognize the nucleoproteins of the four common human coronaviruses. Hydrogen Deuterium eXchange-Mass Spectrometry (HDX-MS) analysis also showed that these VHHs mainly targeted conformational epitopes in either the C-terminal or the N-terminal domains. All VHHs were able to recognize SARS-CoV-2 in infected cells or on infected hamster tissues. Moreover, the VHHs could detect the SARS variants B.1.17/alpha, B.1.351/beta, and P1/gamma. We propose that this sandwich immunoassay could be applied to specifically detect the SARS-CoV-2 N in human nasal swabs.

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Fichiers liés : VHH anti SARS-CoV2 nucleoprotein Lafaye JBC (1).pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Chloé DumotChrystelle PoLucille CapinViolaine HubertElodie OngMatthieu ChourroutRadu BolbosCamille AmazCéline AuxenfansEmmanuelle Canet-SoulasClaire RomeFabien ChauveauMarlène Wiart
• Organismes : Cardiovasculaire, métabolisme, diabétologie et nutrition Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Cardiovasculaire, métabolisme, diabétologie et nutrition Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant CIC CHU Lyon (inserm) Hospices Civils de Lyon Cardiovasculaire, métabolisme, diabétologie et nutrition Groupe d'imagerie neurofonctionnelle Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Cardiovasculaire, métabolisme, diabétologie et nutrition
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Abstract With the aim of designing a preclinical study evaluating an intracerebral cell-based therapy for stroke, an observational study was performed in the rat suture model of ischemic stroke. Objectives were threefold: (i) to characterize neurofunctional and imaging readouts in the first weeks following transient ischemic stroke, according to lesion subtype (hypothalamic, striatal, corticostriatal); (ii) to confirm that intracerebral administration does not negatively impact these readouts; and (iii) to calculate sample sizes for a future therapeutic trial using these readouts as endpoints. Our results suggested that the most relevant endpoints were side bias (staircase test) and axial diffusivity (AD) (diffusion tensor imaging). Hypothalamic-only lesions did not affect those parameters, which were close to normal. Side bias in striatal lesions reached near-normal levels within 2 weeks, while rats with corticostriatal lesions remained impaired until week 14. AD values were decreased at 4 days and increased at 5 weeks post-surgery, with a subtype gradient: hypothalamic < striatal < corticostriatal. Intracerebral administration did not impact these readouts. After sample size calculation (18-147 rats per group according to the endpoint considered), we conclude that a therapeutic trial based on both readouts would be feasible only in the framework of a multicenter trial.

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Fichiers liés : Dumot-2022-Neurofunctional and neuroimaging re.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Matthieu ChourroutMargaux RouxCarlie BoisvertCoralie GislardDavid LeglandIgnacio Arganda-CarrerasCécile OlivierFrançoise PeyrinHervé BoutinNicolas RamaThierry BaronDavid MeyronetEmmanuel BrunHugo RositiMarlène WiartFabien Chauveau
• Organismes : Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Unité de recherche sur les Biopolymères, Interactions Assemblages Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] Imagerie Tomographique et Radiothérapie Imagerie Tomographique et Radiothérapie University of Manchester [Manchester] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Université de Lyon Laboratoire de Lyon [ANSES] Université de Lyon Hospices Civils de Lyon Synchrotron Radiation for Biomedicine = Rayonnement SynchroTROn pour la Recherche BiomédicalE Institut Pascal Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
• Publié dans Biomedical optics express le 31/10/2020

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Résumé : While numerous transgenic mouse strains have been produced to model the formation of amyloid-β (Aβ) plaques in the brain, effi cient methods for whole-brain 3D analysis of Aβ deposits have to be validated and standardized. Moreover, routine immunohistochemistry performed on brain slices precludes any shape analysis of A β plaques, or require complex procedures for serial acquisition and reconstruction. The present study shows how in-line (propagation-based) X-ray phase-contrast tomography (XPCT) combined with ethanol-induced brain sample dehydration enables hippocampus-wide detection and morphometric analysis of Aβ plaques. Performed in three distinct Alzheimer mouse strains, the proposed workflow identified differences in signal intensity and 3D shape parameters: 3xTg displayed a different type of Aβ plaques, with a larger volume and area, greater elongation, flatness and mean breadth, and more intense average signal than J20 and APP/PS1. As a label-free non-destructive technique, XPCT can be combined with standard immunohistochemistry. XPCT virtual histology could thus become instrumental in quantifying the 3D spreading and the morphological impact of seeding when studying prion-like properties of A β aggregates in animal models of Alzheimer’s disease. This is Part II of a series of two articles reporting the value of in-line XPCT for virtual histology of the brain; Part I shows how in-line XPCT enables 3D myelin mapping in the whole rodent brain and in human autopsy brain tissue.

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Fichiers liés : boe-13-3-1640.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/06/2021
• Auteurs : Nihal MartisMatthieu JammeCorinne Bagnis-IsnardClaire Pouteil-NobleClaire PresneCécile VigneauSteven GrangéStéphane BurteyJean-Philippe CoindreAlain WynckelMohamed A HamidouTarik KanouniElie AzoulayMiguel HiéDominique ChauveauAgnès VeyradierEric RondeauPaul Coppo
• Organismes : Centre Hospitalier Universitaire de Nice CHU Pitié-Salpêtrière [AP-HP] Institut de recherche en santé, environnement et travail CHU Pontchaillou [Rennes] CHU Rouen Hôpital de la Conception [CHU - APHM] CHU Montpellier Université Paris 1 Panthéon-Sorbonne CHU Saint-Antoine [AP-HP]
• Publié dans European Journal of Internal Medicine le 22/10/2020

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Résumé : Context - The management of systemic auto-immune diseases (SAID) -associated thrombotic microangiopathies (TMA) [SAID-TMA] remains debated. Objectives - To provide a demographic, clinical and therapeutic picture of SAID-TMA. Methods - A cross-sectional analysis was conducted on adult patients presenting with SAID and TMA from the French National TMA Registry over a 20-year period. Clinical features were extracted and compared to those from a historical cohort of atypical haemolytic and uremic syndrome (aHUS) patients. Results - Forty-one patients with SAID-TMA were compared to 78 patients with aHUS from a historical cohort. Connective tissue diseases (CTD) were systemic lupus erythematosus (n=18), primary Sjögren's syndrome (n=7), systemic sclerosis (n=11), mixed CTD (n=2) and 2 cases of vasculitides, including 7 overlapping forms and 8 cases of primary antiphospholipid syndromes (APLS). Patients with SAID-TMA generally had pre-existing chronic kidney failure (OR= 3.17, 95%CI: 1.204 to 7.923; p= 0.016) compared to aHUS patients, though creatinine levels were significantly lower (216 [IQR, 108-334] µmol/L vs. 368 [IQR, 170-722] µmol/L; p= 0.002). Patients were less likely to recover if renal replacement therapy was needed at onset (OR= 0.07; 0.02 to 0.34; p <0.0005). Two patients died. Thirty patients responded to immunosuppressive treatment and complete remission was achieved in 25 cases. By contrast, therapeutic plasma exchange (TPE) did not have an early effect on TMA features at Day-7 nor Day-15 (p >0.05). Conclusion - The management of SAID-TMA implies an early initiation of immunosuppressive drugs for flares of the associated SAID, whereas TPE seem ineffective. KEY MESSAGES.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2020
• Auteurs : Cécile CouchoudFlorian BayerCarole AyavClémence BéchadeAbdelhamid AbbassiAlain DebureAbdallah GuerraouiAbdelatif BenmoussaAbdelaziz HamaniAbdelaziz ZianeAbdelhamid NeftiAbdelkader HadjAbderrahim El AmariAbderrahmane GhazaliAbo Bakr Abd El Fatah MohamedAchour LaradiAdel Ben AhmedAdel SaharAdele PilletAdeline LacrazAdnan MoinatAfshin MassoumiAgathe PardonAgnes Caillette BeaudoinAgnes Chapelet DeboutAgnes MariotAhmed RachiAida AfianiAime Remy BoulaAl JalabyAlain CremaultAlain FournierAlain JeansonAlain LyonAlain NonyAlain RobertAlain SlingeneyerAlanor Agnes LabatideAlbane Brodin SartoriusAlbert BensmanAlbert FournierAlex RanlinAlex Vido SandorAlexandra ColomboAlexandra DuhemAlexandra StancuAlexandre DufayAlexandre DumoulinAlexandre EbelAlexandre KleinAlexandre MartinAlexandre MouneimneAlexandre SeidowskyAlfio de MartinAlfredo ZannierAli AizelAli HafiAli Zineddine DiddaouiAlim HeyaniAlina MocanuAlina PredaAline HafiAline TalaszkaAlyette DuquesneAmar AmaoucheAmel GhemmourAmelie SimonAmina SkalliAmine BoukadidaAmr Ekhlas Ragab EidAna FedorcaAnabelle BailletAnais PoyetAncuta Bouffandeau GiorgitaAnderson RatsimbazafyAndre PrunaAngel ArgilesAngelo TestaAnn Karolien VandoorenAnne JolivotAnne Kolko LabadensAnne LatasteAnne MaisinAnne ParisAnne SechetAnne WuillaiAnne-Elisabeth HengAnne Gaelle JosseAnne Helene QuerardAnne Helene RebouxAnne Laure AdraAnne Laure FallerAnne Laure LeclercAnne Laure PoitouAnnie Lahoche ManucciAntoine JacquetAntoine PommereauAntoine ThierryArezki AdemArielle ChapeletArnaud del BelloArnaud DelezireArnaud GarnierArnaud GuerardArnaud KlisnickArnaud LionetArnaud RoccabiancaArnaud StolzArthur CapdevilleAsma AllalAssem AlrifaiAssetou DiarrassoubaAssia DjemaAssia Ferhat CarreAstrid Godron DubrasquetAtman Haddj ElmrabetAudrey JegadoAurelia Bertholet ThomasAurelie Davourie SalandreAurelie PajotAurelien LorthioirAurelien TipleAurore SuryAyman AbokasemAyman SarrajBachir HenaouiBaher ChaghouriBassem WehbeBeatrice BallBeatrice VironBelkassem IssadBenedicte Hodemon CorneBenedicte JanbonBenjamin DeroureBenjamin SavenkoffBenoit JononBenoit VendrelyBenyakoub DjelaleddineBernard OhryBernard PainchartBernard StrulluBernard TempervilleBertin EbikiliBertrand HacqBertrand MorelBilal AounBlanca MunizBouchra ChlihBrahim AmaraBrice MayorBrigitte GilsonBrigitte LlanasBrigitte ZinsBruno BourgeonBruno CoevoetBruno GueryBruno LegallicierBruno ParisBruno RanchinBruno SeigneuricCamelia Ghiciuc DitaCamelia PrelipceanCarine Achard HottelartCarine DietCarlos FrangieCarlos VelaCarmina MuresanCarole DepreleCaroline AraujoCaroline BidaultCaroline CreputCaroline DelclauxCaroline Du HalgouetCaroline FavennecCaroline FreguinCaroline Gourraud VercelCaroline MesguenCaroline Ndomo ObamaCaroline PoitouCaroline Preissig DirholdCaroline RoubiouCatherine AlbertCatherine BessinCatherine de Marion GajaCatherine GodartCatherine LasseurCatherine LeocardiCatherine LumbrosoCatherine MelanderCatherine MichelCatherine Quere MaurouardCatherine RouannetCatherine TaddeiCathy VeroveCecile GuiraudCecile TafelinCecile Turc BaronCedric FormetCedric PinierCelia Lessore de Ste FoyCeline GranollerasChaouki BenniniCharles CartouCharles ChazotCharlotte JouzelCherif BadidChrista RoubicekChristel ViaudChristelle VerrierChristian ChuetChristian CombeChristian DabotChristian DuvicChristian EmondChristian LagardeChristian LamotteChristian PainChristiane MoussonChristie LorriauxChristine BeauchampChristine FumeronChristine Le GurunChristine LeroyChristine PietrementChristine RicherChristophe BouakaChristophe CharasseChristophe GoupyChristophe RidelCindy CastraleCindy DetourneClair FrancoisClaire PresneClaire TrivinClarissa von KotzeClaude BernardClaude BonniolClaude DesvergnesClaude RaharivelinaClaudia NistorClaudine GueretClaudine LloretClaudine SaltielClelia RosatiClementine RabateCorina StanescuCorinne FerrandiniCorinne GuibergiaCorinne LemoineCorinne PasseronCynthia KahilCyril GarrousteCyril Vo VanCyrille JolimoyDalila KesraouiDamien JollyDamien ThibaudinDan TeboulleDaniel DaubresseDaniel LouvetDaniel RasamimanantsoaDaniel ToledanoDaniela BabiciDaniela DavidDaniela DincuDanielle BrunoDelia MayDelphine HaussaireDelphine Henriet VipreyDenis BugnonDenis FouqueDenis MorinDerradji NourDiab Mohamed MahmoudDiana Istrati CristescuDidier AguileraDidier CosteDidier HamelDidier Le ChapoisDidier TestouDilaver ErbilginDjamal DahmaneDoan Bui QuangDominique BertrandDominique BesnierDominique BlanchierDominique BriffaDominique CauxDominique DurandDominique FleuryDominique GuerrotDominique HestinDominique JaubertDominique JolyDominique LombartDominique PagniezDominique PierreDominique SchohnDonatien IkongaDorina VisanicaDorothee BazinEdouard BouryEdouard MaksourEkoue AgbononElarbi HarramiElena MarcuElena TudoracheElisabeth CaniotElisabeth SemjenElisabeth TomkiewiczElise ScheidtElke GaboriauElodie LamourouxElsa GuiardElsa Martin PassosEmerson NsembaniEmilie FacheEmilie KalbacherEmilie PambrunEmilie PinconEmma Allain LaunayEmmanuel BaronEmmanuel DupuisEmmanuel VillarEmmanuelle CharlinEmmanuelle HecquetEmmanuelle KohlerEmmanuelle LaurainEmmanuelle RosierEnrique FigueroaEric AzoulayEric CanivetEric DaugasEric GauthierEric LaruelleEric Le GuenEric LegrandEric MoumasEric PostecEric PrinzEric RenaudineauEstelle DesportEstelle Ricard SutraEtienne BerardEtienne GedEtienne RobinEve VilaineEvelyne BargasEvelyne Mac NamaraFrançois CombarnousFatima YazbeckFabien GerardFabien MetivierFabien ParazolsFabien SoulisFabrice GarnierFadhila Pech MessaoudeneFadi HaidarFanny BoullengerFanny LepeytreFanny LeroyFares FrejateFarid BellahseneFarid BellhaseneFarid SaidaniFatouma ToureFaycal KriaaFazia NemmarFernando VetromileFlorence ChalminFlorence LucatsFlorence SensFlorence VillemainFlorent PlasseFouad LebhourFrancis SchillingerFranck BergeFranck BourdonFranck BridouxFranck ReynaudFrancois BabinetFrancois BasseFrançois ChantrelFrancois ClairFrancois CoulombFrancois de CornelissenFrancois GlowackiFrancois MarchalFrancois MauriceFrancois NobiliFrancois PourreauFrancois ProvotFrancois Roux AmaniFrancoise BrouxFrancoise BulteFrancoise HeibelFrancoise LeonettiFrancoise Moussion SchottFrank Le RoyFrederic BessonFrederic LavainneFrederic TollisFrederique BocquentinFrederique MeeusFrederique VecinaFriederike von EyGabriel BalitGabriel ChoukrounGabriel GrugetGabriel HuchardGabriella GoleaGabrielle DuneauGaelle LefrancoisGaelle PelleGaetan LebrunGenevieve DumontGeorges BrilletGeorges DeschenesGeorges MouradGeorges StamatakisGeraldine CazajousGeraldine d'YthurbideGeraldine Robitaille WiartGerard CardonGerard ChampionGerard DeschodtGerard MangenotGerard MotteGerard SchortgenGhada BoulahiaGhassan MaakarounGhylene Bourdat MichelGilbert ZanettaGilles HufnagelGilles MessierGiorgina PiccoliGregoire Couvrat DesvergnesGuillaume BobrieGuillaume BonnardGuillaume ClementGuillaume JeanGuillaume QueffeulouGuillaume SeretGuillaume VerninGuy DelavaudGuy LambreyGuy RostokerGwenaelle PoussardGwenaelle Roussey KeslerH. LeonHabib AboubekrHacene BoulechfarHacene SekhriHadia HebibiHadjira BenaliaHafed FessiHafsabhai AtchiaHaiat BittarHakim MaizaHakim MazouzHamid El AliHammouche BougridaHans van Der PijlHassan LokmaneHassane IzzedineHassen AddaHelene de PreneufHelene LerayHelene PhilippotHenri BoulangerHenri MeraultHenri RenaudHerve BonarekHerve MaheutHilaire NzeyimanaHocine MehamaHocine ZaidiHugo WeclawiakHugues FlodropsHuseyin KaraaslanIbrahim HaskourIhssen BelhadjImad AlmoubarakImad HaddadInes CastellanoInes FerrandizIoana DaniliucIoana DarieIoana EnacheIonut PrunescuIrenee DjiconkpodeIrina ShahapuniIsabelle BouchouleIsabelle DevriendtIsabelle KazesIsabelle KolbIsabelle LandruIsabelle PoliIsabelle ReyIsabelle SegalenIsabelle SelcerIsabelle VernierIsabelle VrillonIsmahane GuenifiJ. Dominique GheerbrandtJacky PotierJacques BecartJacques CledesJacques DucrosJacques DuvicJacques FourcadeJacques GaultierJacques JurineJacques LebleuJacques OllierJacques Ibsen CharlesJamal YazjiJanette MansourJean ArnautouJean BrocardJean CarolfiJean MontoriolJean Baptiste GouinJean Bernard PalcouxJean Christophe BendiniJean Claude AldigierJean Claude AlphonseJean Daniel DelbetJean Francois BonneJean Francois CantinJean Francois de FremontJean Francois DessassisJean Francois SubraJean Francois ValentinJean Francois VerdierJean Jacques DionJean Jacques HaultierJean Jacques MontsenyJean Louis BacriJean Louis BouchetJean Luc MaheJean Marc ChalopinJean Marc GabrielJean Marc HurotJean Marc LanauJean Marie BathoJean Marie CoulibalyJean Michel HardinJean Michel MarcJean Michel PouxJean Michel RebibouJean Michel TivollierJean Noel OttavioliJean Paul FauconJean Paul ImielaJean Paul JaulinJean Paul MasselotJean Paul OrtizJean Philippe BourdenxJean Philippe DevauxJean Philippe HammelinJean Pierre RivoryJean Pierre WauquierJean Rene LarueJean Rene MondainJean Sebastien BordeJean Simon VirotJean Yves BoscJedjiga AchicheJennifer ParasoteJeremie DiolezJerome HarambatJerome PotierJerome SampolJihad MustelJean Jacques LefevreJocelyne MauriziJoel GamberoniJoelle ClaudeonJoelle TerzicJoffrey RogolJohnny SayeghJorge CardozoJose BrasseurJose GuiserixJoseph BarsumauJulie AlbaretJulie BeaumeJulie Sohier AttiasJulien DehayJulien HoganJulien JournetJulien OttJuliette BaleynaudJustine BacchettaJustine FaucherKamel YousfiKarim DardimKarine ClabaultKarine MoreauKedna ThomasKhaled SirajedineKhalil ChedidKhalil El KaeouiKhalil El KarouiKhedidja BouachiKheira HueKhuzama El NasserKodso AkpossoKristian KunzKrzysztof BijakLilia KihalL. RasoloarijaonaLaid HarboucheLarbi BencheikhLarbie LamribenLatifa HanafiLaura Braun ParvezLaure ChampionLaure CrozeLaure EprinchardLaure PatrierLaurence NicoletLaurence VrigneaudLaurent DuflotLeandre MackayaLeila ChenineLeon OdryLili Taghipour TamijiLilia Antri BouzarLiliane Ngango Nga MessiLionel Le MouellicLise MandartLise WeisLise Marie PouteauLora GeorgievaLorita VitanovaLotfi ChalabiLuc DelvallezLuc FrimatLuc FromentinLuc MartyLuc MonjotLuciana SpataruLucie BessenayLucie BoissinotLucie WajsbrotLucien RakoffLudivine LebourgLydie PerezLyliane LafageLynda AzzouzMadeleine DumoulinMessaoud OuzialaMaan JosephMabrouk BrahimiMaeva Wong FatMagalie FortMagued NakhlaMahdi AbtahiMahen AlbadawyMahmoud AlouachMahmoud MezghaniMaite DarouxMaklouf BoukelmouneMalek DhibMalik TouamMalina DubauMamadou BaldeMan Nguyen KhoaManfred IsmerManolie MehdiManon LaforetMarc BouillerMarc EugeneMarc FilaMarc HazzanMarc KribsMarc LadriereMarc LebotMarc PadillaMarc SouidMarcel MarraouiMaren BurbachMaria ManescuMaria Eugenia Noguera GonzalezMariana RevencoMarianne TerrasseMarie EssiMarie Alice MacherMarie Beatrice NogierMarie Cecile CazinMarie Christine Schweitzer CamoinMarie Christine ThouretMarie Claude HannaertMarie France ServelMarie Helene ChabannierMarie Jeanne Coudert KrierMarie Noelle CatoliquotMarie Paule GuillodoMarie Sophie GavardMarie Xaviere Vairon CodaccioniMarina RabecMarine FreistMarion GauthierMarion LemaireMarion MehrenbergerMarion VenotMarios PongasMarlene Beaubrun DiantMartial LevannierMartine BertauxMathieu JablonskiMathieu SacquepeeMathilde DargelosMathilde LemoineMathilde TamainMatthieu MongeMatthieu ReberolleMaud CousinMaud FrancoisMaurice BaronMaxime HoffmannMaxime IngwillerMaxime TouzotMederick MohajerMehadji MaazMelanie HanoyMelanie MarrocMelodie CunyMenno van Der StraatenMf. ServeauxMichel BasteriMichel Fen ChongMichel HechtMichel MassadMichel NormandMichel OlmerMichel TolaniMichel TsimaratosMichele HemeryMichele KesslerMiguel EspositoMilad ShenoudaMimi KarecheMina KhaliliMirella DiaconitaMohamad Khair RifardMohamed AladibMohamed BelmouazMohamed BrahimMohamed DiouaniMohamed Fodil CherifMohamed JamaliMohamed MaghlaouaMohamed MeddebMohamed RamdaneMohamed RifaatMohamed Sharifull IslamMohamed Adnan AbbadeMokhtar AmrandiMokhtar ChawkiMonica CiobotaruMonica IndrieisMonique ChanasMonique HoarauMonzer TomehMoufida BellouMouloud BouzernidjMounia AmmorMounir GuergourMountassir BenzakourMourad HachichaMoussa CoulibalyMustafa SmatiMustapha Al MorabitiMustapha AmirouMyriam IsnardMyriam PasturalMyriam PujoNourredine BoumendjelNabil MajbriNabila GoumriNadege MingatNader BassiliosNadia KerkeniNadia SedratiNadia SoltaniNadine MarounNadine NeyratNahn LuangNajeh El EsperNaji AmmarNasredine GhaliNasser HamdiniNatacha NoelNatacha PoteluneNathalie MaisonneuveNathalie PertuisetNathalie RaynalNathalie VittozNazim TerkiNelly CastinNestor NankeuNicolas BouvierNicolas KellerNicolas LegrosNicolas PetersNicolas QuirinNicole LefrancoisNicole MonnierNicole RanceNiels BruckmannNoel MertensNolwenn LorcyOlivia GilbertOlivier ColdefyOlivier DrouineauOlivier DunandOlivier FritzOlivier ImhoffOlivier KourilskyOlivier LavelleOlivier MoranneOlivier PapinOlivier RoquesOphelie Le ManerOussamah Fikri BenbrahimPablo Antonio Erina TorresPablo Antonio Urena TorresPaolo MalvezziPascal BindiPascal CluzelPascal FontanierPascal WheatleyPascale DepraetrePascale DubosqPascale HalinPascale SebahounPascale SiohanPascale TestevuidePatrice DeteixPatrice NolenPatricia HuePatricia LemarchandPatrick DonnadieuPatrick FievetPatrick FohrerPatrick FrancaisPatrick GiraudPatrick HallonetPatrick HenriPatrick MichautPatrick NiaudetPatrick PaulyPatrick ThomasPatrik DeleavalPaul FinielzPaul StroumzaPaule Hardy YverneauPauline CaillardPedro PalacinPerrine AubertinPhilippe AttiasPhilippe BrunetPhilippe ChauveauPhilippe CoindrePhilippe CostePhilippe DubotPhilippe FournierPhilippe HiernauxPhilippe JoussetPhilippe Lan Yue WahPhilippe LangPhilippe Le CacheuxPhilippe Martin DupontPhilippe MichelPhilippe MirgainePhilippe MorinierePhilippe NicoudPhilippe RieuPhilippe RousseauPhilippe SporerPhilippe ThorelPhilippe VanhillePhilippe VigeralPhilippe ZaouiPierre BataillePierre BrignonPierre FilipozziPierre HoussetPierre PeyronnetPierre RamperezPierre VautrinPierre Alexandre MichelPierre Francois WesteelPierre Louis CarronPierre Yves DurandPierrot ParentPiotr SeniutaFrançois KuentzRabah FraouiRachel TetazRachid AmariaRachid BouroumaRachid DjeffalRachida NebbadRadia AllalRadu DimulescuRafaat BoustaniRafik MesbahRaifat MakdassiRaji DiabRaluca PuslengheaRaoul RouraRateb KhayatRaymond AzarRaymond FrayssinetRegine MonkamRehouni BoulahrouzRemi BoudetRenato DemontisRenaud GanseyRene CuvelierRenee SchmittReschad NoordallyReynald BinautRezkallah LatifRichard DufresneRichard MontagnacRichard ReadeRobert GeninRobert NovoRocsana FicklRoger DufresneRoger MagnolRoland IssautierRomain MorteletteRonan DelavalRonan LohroRoseline M'BargaS. 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ChateletTania OnestaTassadit BenhabibTayeb BensalemTheodora DimulescuTheophile SawadogoThibault Dolley HitzeThierry BarangerThierry BoudemagheThierry HannedoucheThierry KrummelThierry LobbedezThierry MilcentThomas DervauxThomas GuincestreThomas KofmanThomas RaphaelThomas SadreuxTim UlinskiTiphaine Guyon RogerTomas SerratoTomek KofmanTony WongToufik BoubiaUbald Assogba GbindounUsama KhuzaieValerie CaudwellValerie ChateletValerie CrougneauValerie de PrecigoutValerie DrouillatValerie GalantineValerie Granveau HugotValerie LeroyVeronique BoubiaVeronique FalqueVeronique FournierVeronique QueronVeronique VivianiVictor GueuttinVictor PanescuVictorio Menoyo CalongeViet NguyenVincent AllotVincent DelattreVincent LeducVincent PradierViolaine Emal AglaeViorica BadulescuVirginia MolinaVirginie BessonVirginie ChaigneWaddah JaberWael BoudiWael El HagganWen Qin GuillonWided Tabbi AneniWilliam HanfWladimir KohnXavier BellenfantXavier Moreau GaudryYahsou DelmasYannick KnefatiYannick SaingraYannick TirolienYoussef MannYvan BrunakYves DimitrovYves DoussyYves TanterZaid BenabidZaara SoltaniZacharia BoukerrouchaZafer TaklaZana RamanantsialoninaZara DicksonZead TubailZoe Koochaki PourZohra BoukhalfaZohra JacquotRoula GallandMaryvonne HourmantLucile Mercadal
• Organismes : Agence de la biomédecine [Saint-Denis la Plaine] Agence de la biomédecine [Saint-Denis la Plaine] Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy] Centre Universitaire des Maladies Rénales [CHU Caen] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Centre Hospitalier Régional Universitaire de Nancy Groupe hospitalier de la région de Mulhouse Sud-Alsace Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 Service de Néphrologie [CHPC - Site Louis Pasteur] Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Nîmes Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 Assistance Publique - Hôpitaux de Marseille Centre Universitaire des Maladies Rénales [CHU Caen] CALYDIAL Vienne Centre hospitalier universitaire de Nantes Service de Diabétologie [CHU Pitié-Salpétrière]
• Publié dans Kidney International le 27/10/2020

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Résumé : The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed.

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• Type de publi. : Article dans une revue
• Date de publi. : 31/10/2020
• Auteurs : Paul Le TurnierMatthieu GrégoireGuillaume DeslandesKarim LakhalColin DeschanvresRaphael LecomteJean Philippe TalarminV. DubéeRonan BellouardDavid BoutoilleAnne-Gaëlle LeroyB.J. GaboritFrancois RaffiCharlotte BironMaeva LefebvreBenjamin Jean GaboritMarie ChauveauNathalie AsserayEric DaillyStéphane CorvecPascale BémerJocelyne CaillonAurélie GuillouzouicRaphaël CinottiEmmanuel CanetCédric BretonniereThomas GuimardJulia BrochardLydie Katchatourian
• Organismes : The Enteric Nervous System in gut and brain disorders [U1235] Université d'Angers DCNS Group [Nantes] DCNS Group [Nantes] DCNS Group [Nantes]
• Publié dans Clinical Microbiology and Infection le 30/10/2020

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Fichiers liés : S1198743X20302743.pdf

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