Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2010
• Auteurs : Jean-Philippe EmpanaXavier JouvenFlorence Canouï-PoitrineGerald LucMuriel TaffletBernadette HaasDominique ArveilerJean FerrieresJean-Bernard RuidavetsMichèle MontayeJohn YarnellPierre MorangeFrank KeeAlun EvansPhilippe AmouyelPierre Ducimetiere
• Organismes : INSERM U258 AVENIR Team 'Epidemiology of sudden cardiac death'
• Publié dans Arteriosclerosis, Thrombosis, and Vascular Biology le 27/10/2020

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Résumé : Objective— To examine prospectively the association of high-sensitivity C-reactive protein, interleukin 6, and fibrinogen with sudden death in asymptomatic European men. Methods and Results— Among the 9771 men from the Etude PRospective de l’Infarctus du Myocarde (PRIME) Study, 664 had a first coronary heart disease over 10 years, including 50 sudden deaths, 34 nonsudden coronary deaths, and 580 nonfatal coronary heart disease events. For each outcome, 2 matched controls, who were free of coronary heart disease at the index date, were randomly selected from the initial cohort (nested case control study design). There was a 3-fold increased risk (95% CI, 1.20 to 7.81) of sudden death between the upper and the lower third of interleukin 6 after adjustment for baseline confounders in conditional logistic regression analysis. Neither high-sensitivity C-reactive protein (hazard ratio third versus first tertile =1.27; 95% CI, 0.51 to 3.17) nor fibrinogen (hazard ratio third versus first tertile =1.90; 95% CI, 0.76 to 4.75) was associated with sudden death. For comparison, there was a 6-fold increased risk of nonsudden coronary death from the highest compared with the lowest tertile of fibrinogen and a trend toward an association with higher C-reactive protein and higher interleukin 6. All 3 inflammatory biomarkers were moderately, but significantly, associated with nonfatal coronary heart disease. Conclusion— Interleukin 6, but not high-sensitivity C-reactive protein or fibrinogen, is an independent predictor of sudden death in asymptomatic European men.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2010
• Auteurs : Béatrice LegouinMaud GayralPhilippe UriacJean-François CupifNicolas LevoinLoic ToupetPierre van de Weghe
• Organismes : Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Laboratoire Bioprojet Organométalliques et catalyse : chimie et électrochimie moléculaires Institut des Sciences Chimiques de Rennes
• Publié dans European Journal of Organic Chemistry le 22/10/2020

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Résumé : A chiral molecular tweezer obtained from (+)-usnic acid placed in solution in the presence of various aromatic compounds afforded complexes with low association constants. Thus, the X-ray structure of assembly 3i is presented, where the guest is sandwiched between the two pincers of the tweezer. The association constants for various guests were determined through different methods. Finally, other tweezers with electron-rich aromatic aldehydes and ketones were prepared from (1R,2R)-1,2-diaminocyclohexane. The most interesting complexes were also confirmed through structural analysis, and the best results were obtained with 10-hydroxyphenanthrene-9-carbaldehyde (5i) as the aromatic moiety.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2010
• Auteurs : Gérald RaverotNathalie SturmFlorence de FraipontMarie MullerSylvie SalenavePhilippe CaronOlivier ChabrePhilippe ChansonChristine Cortet-RudelliRichard AssakerHenry DufourStéphan GaillardPatrick FrançoisEmmanuel JouanneauJean-Guy PassagiaMichèle BernierAurélie CornéliusDominique Figarella‑brangerJacqueline TrouillasFrançoise Borson-ChazotThierry Brue
• Organismes : Institut d'oncologie/développement Albert Bonniot de Grenoble Département d'anatomie et cythologie pathologique Institut d'oncologie/développement Albert Bonniot de Grenoble Laboratoire d'Imagerie Paramétrique Service Endocrinologie, maladies métaboliques et nutrition [CHU Toulouse] Département d'endocrino-diabétologie, maladies de la nutrition Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique Service d'Endocrinologie et Maladies de la reproduction Service de neurochirurgie [CHU Marseille] Centre de recherche en neurobiologie - neurophysiologie de Marseille Galaxies, Etoiles, Physique, Instrumentation Institut de Chimie des Substances Naturelles Service de pathologie et neuropathologie Centre de recherche en neurobiologie - neurophysiologie de Marseille
• Publié dans Journal of Clinical Endocrinology and Metabolism le 01/11/2020

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Résumé : CONTEXT: To date only 18 patients with aggressive pituitary tumors or carcinomas treated with temozolomide have been reported. Increased expression of O6-methylguanine-DNA-methyltranferase (MGMT) has been suggested to predict resistance to temozolomide. OBJECTIVES: The objective of the study was to describe the antitumoral efficacy and toxicity of temozolomide in patients with aggressive pituitary tumors or carcinomas and evaluate the possible prognostic value of MGMT promoter methylation and protein expression. PATIENTS: Eight patients, five with pituitary carcinomas (three prolactin (PRL) and two ACTH) and three with aggressive pituitary tumors (one PRL and two ACTH), all treated with temozolomide administered orally for four to 24 cycles, were included in our French multicenter study. DESIGN: MGMT expression was assessed by immunohistochemistry and MGMT promoter methylation by pyrosequencing. RESULTS: Three of the eight patients (two ACTH adenomas and one PRL carcinoma) responded to temozolomide as demonstrated by significant tumor shrinkage and reduced hormone secretion. Three cycles of temozolomide were sufficient to identify treatment-responsive patients. Additional cycles did not improve treatment efficacy in those not responding, even when associated with carboplatin and vepeside. MGMT expression did not predict tumoral response to temozolomide because it was positive in one responder and negative in two nonresponders. Similarly, MGMT promoter methylation (three of seven tumors) did not predict clinical response. Toxicity remained mild in all patients. CONCLUSION: Temozolomide treatment may be an effective option for some aggressive pituitary tumors or carcinomas. Response to a trial of three cycles of treatment seems sufficient to identify responders and more reliable than patient MGMT status.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/09/2010
• Auteurs : Amélie CharlesOlivier DarnéJean-François HoarauPhilippe Jean-Pierre
• Organismes : Audencia Business School

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• Type de publi. : Article dans une revue
• Date de publi. : 30/09/2010
• Auteurs : Gilles MillatPatrice BouvagnetPhilippe ChevalierClaire DauphinPierre Simon JoukAntoine da CostaFabienne PrieurJean-Luc BressonLaurence FaivreJean-Christophe EicherNicolas ChassaingHervé CrehaletRaphaël PorcherClaire Rodriguez-LafrasseRobert Rousson
• Organismes : Laboratoire de Cardiogénétique Laboratoire Cardiogénétique Service de cardiologie RFMQ Service de Génétique Clinique Chromosomique et Moléculaire Service de Biochimie [Mondor] Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon) Service de Cardiologie [CHU de Dijon] Centre de Physiopathologie Toulouse Purpan Service de Biochimie et Biologie Moléculaire Service de Biostatistiques Centre Hospitalier Lyon Sud [CHU - HCL] Laboratoire de Cardiogénétique
• Publié dans European Journal of Medical Genetics le 22/10/2020

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Résumé : Hypertrophic Cardiomyopathy (HCM), a common and clinically heterogeneous disease characterized by unexplained ventricular myocardial hypertrophy and a high risk of sudden cardiac death, is mostly caused by mutations in sarcomeric genes but modifiers genes may also modulate the phenotypic expression of HCM mutations. The aim of the current study was to report the frequency of single and multiple gene mutations in a large French cohort of HCM patients and to evaluate the influence of polymorphisms previously suggested to be potential disease modifiers in this myocardial pathology. We report the molecular screening of 192 unrelated HCM patients using denaturing high-performance liquid chromatography/sequencing analysis of the MYBPC3, MYH7, TNNT2 and TNNI3 genes. Genotyping of 6 gene polymorphisms previously reported as putative HCM modifiers (5 RAAS polymorphisms and TNF-α -308 G/A) was also performed. Seventy-five mutations were identified in 92 index patients (48%); 32 were novel. MYBPC3 mutations (25%) represent the most prevalent cause of inherited HCM whereas MYH7 mutations (12%) rank second in the pathogenesis. The onset age was older in patients carrying MYBPC3 mutations than in those with MYH7 mutations. The MYBPC3 IVS20-2A>G splice mutation was identified in 7% of our HCM population. Multiple gene mutations were identified in 9 probands (5%), highlighting the importance of screening other HCM-causing genes even after a first mutation has been identified, particularly in young patients with a severe phenotype. No single or cumulative genetic modifier effect could be evidenced in this HCM cohort.

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• Type de publi. : Article dans une revue
• Date de publi. : 30/09/2010
• Auteurs : Jean-Pierre GangneuxC CamusB Philippe
• Organismes : Institut de recherche en santé, environnement et travail
• Publié dans Revue des Maladies Respiratoires le 31/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/09/2010
• Auteurs : F. LebrunF. AharonianVolker BeckmannW. BertoliJ.-M. BromA. BykovS. BrandtT. BulikC. Budtz-JorgensenI. CaballeroJohann Cohen-TanugiA. CreusotF. DaigneM. DenisL. DruryY. GallantN. GehrelsU. GoerlachD. GötzC. HamadacheW. HermsenJ. KienerL. KuiperG. LamannaPhilippe LaurentO. LimousinF. MattanaAlexandre MarcowithT. NeubertC. OlivettoP. OrleanskiE. ParizotJean-Louis PinçonT. PradierS. SchanneN. de SérévilleS. SoldiMatthieu RenaudMichel TaggerV. TatischeffRégis TerrierR. WalterSei-Ichiro WatanabeJ.A. Zurita Heras
• Organismes : APC - Astrophysique des Hautes Energies AstroParticule et Cosmologie AstroParticule et Cosmologie Institut Pluridisciplinaire Hubert Curien Astrophysique Interprétation Modélisation Laboratoire de Physique Théorique et Astroparticules AstroParticule et Cosmologie Institut d'Astrophysique de Paris Laboratoire de Physique Théorique et Astroparticules Institut Pluridisciplinaire Hubert Curien Astrophysique Interprétation Modélisation Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse Laboratoire d'Annecy de Physique des Particules APC - Astrophysique des Hautes Energies Astrophysique Interprétation Modélisation AstroParticule et Cosmologie Laboratoire de Physique Théorique et Astroparticules AstroParticule et Cosmologie AstroParticule et Cosmologie Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Institut Pluridisciplinaire Hubert Curien Astrophysique Interprétation Modélisation Institut de Physique Nucléaire d'Orsay Astrophysique Interprétation Modélisation Laboratoire de Physique Théorique et Astroparticules Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse AstroParticule et Cosmologie AstroParticule et Cosmologie

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Résumé : Proposed in response to the ESA call for the third Medium size mission (M3), CAPSiTT is a small mission designed for a 3-year survey of the non-thermal high energy sky from an equatorial LEO orbit. With a large effective area and a very wide field of view, its single instrument, a silicon tracker, provides good imaging, spectroscopic and polarimetric capabilities with a sensitivity 10-100 times better than COMPTEL. Nucleosynthesis and particle acceleration mechanisms in various sites are the main scientific topics addressed by CAPSiTT.

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Fichiers liés : INTEGRAL_2010_034.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/09/2010
• Auteurs : Wigneron J.-P.N. NovelloYann H. KerrFrançois CabotS. DelwartFrançois DemontouxA. GovindD. GuyonElsa JacquetteHeather LawrenceE. Lopez-BaezaAli MahmoodiC. MattarS. MecklenburgArnaud MialonC. MoisyKhaldoun SalehPhilippe RichaumeMike SchwankJ. SobrinoPhilippe Waldteufel
• Organismes : Écologie fonctionnelle et physique de l'environnement Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère European Space Research and Technology Centre Laboratoire de l'intégration, du matériau au système Écologie fonctionnelle et physique de l'environnement Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Laboratoire de l'intégration, du matériau au système Universitat de València = University of Valencia = Universidade de Valencia Array Systems Global Change Unit European Space Research Institute Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Swiss Federal Institute for Forest, Snow and Landscape Research WSL Global Change Unit ESTER - LATMOS

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Résumé : The SMOS (Soil Moisture and Ocean Salinity) mission was launched on November 2, 2009. It is the second Earth Explorer Opportunity mission to be developed as part of ESA's Living Planet Programme. It aims to improve our understanding of the Earth's water cycle by making global observations of soil moisture over land and salinity over oceans. Over the land surfaces, SMOS will advance our understanding of the exchange processes between the Earth's surface and atmosphere, and will have many applications to improve weather and climate models and in areas such as agriculture and water resource management. Over the land surfaces, the principle of the SMOS Level 2 retrieval algorithm is to exploit multi-angular data in order to retrieve simultaneously several surface parameters including surface soil moisture (SM) and vegetation characteristics. The L-MEB (L-band Microwave Emission of the Biosphere) forward model was selected to simulate the microwave signatures of the various soil and vegetation types which are present in the mixed SMOS pixel, which is larger than about 30 x 30 km generally. The study presented in this paper was carried out in the framework of this assessment process over the land surfaces. Preliminary analyses evaluating the Smos observations in terms of Brightness Temperatures (TB) and L2 products (mainly soil moisture SM and vegetation optical depth) were carried out over several sites at global scale.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/09/2010
• Auteurs : Wigneron J.-P.Yann H. KerrArnaud MialonNathalie NovelloFrançois CabotSteven DelwartFrançois DemontouxMaria Jose EscorihuelaP. FerrazzoliAjit GovindJennifer GrantDominique GuyonElsa JacquetteHeather LawrenceErnesto Lopez-BaezaAli MahmoodiCristian MattarSusanne MecklenburgChristophe MoisyS. MonerrisR. RahmounePhilippe RichaumePatricia de RosnayC. RüdigerKauzar Saleh ContellMike SchwankJose A. SobrinoPhilippe Waldteufel
• Organismes : Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère European Space Research and Technology Centre Laboratoire de l'intégration, du matériau au système isardSAT Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie] Écologie fonctionnelle et physique de l'environnement European Space Research and Technology Centre Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Universitat de València = University of Valencia = Universidade de Valencia Array Systems Computing Universitat de València = University of Valencia = Universidade de Valencia ESA Centre for Earth Observation Écologie fonctionnelle et physique de l'environnement Barcelona Expert Centre Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie] Centre d'études spatiales de la biosphère European Centre for Medium-Range Weather Forecasts Monash University [Clayton] Department of Geography [Cambridge, UK] Institut Fédéral de Recherches sur la Forêt, la Neige et le Paysage Universitat de València = University of Valencia = Universidade de Valencia ESTER - LATMOS

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/09/2010
• Auteurs : Jean-Pierre LagouardeMichel BachJose A. SobrinoGilles BouletXavier BriottetSelma CherchaliBenoît CoudertIsabelle DadouGérard DedieuPhilippe GametOlivier HagolleFrédéric JacobFrançoise NerryAlbert OliosoCatherine OttlePhilippe PascalJean-Louis C. H. RoujeanFrancesco Tintó Garcia-Moreno
• Organismes : Écologie fonctionnelle et physique de l'environnement Centre National d’Etudes Spatiales Universitat de València = University of Valencia = Universidade de Valencia Centre d'études spatiales de la biosphère ONERA - The French Aerospace Lab [Toulouse] Centre National d’Etudes Spatiales Centre d'études spatiales de la biosphère Institut Universitaire de Technologie - Paul Sabatier Université Toulouse III - Paul Sabatier Centre d'études spatiales de la biosphère Centre National d’Etudes Spatiales Centre d'études spatiales de la biosphère Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Centre National d’Etudes Spatiales Météo-France Direction Interrégionale Sud-Est Centre National d’Etudes Spatiales

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Fichiers liés : Lagouarde-RAQRS2010-MISTIGRI_1.pdf

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