Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Jeremy GuendouzPierre BuffièreJuan CachoMyriam CarrèreJean-Philippe Delgenès
• Organismes : VEOLIA France Laboratoire de Génie Civil et d'Ingénierie Environnementale VEOLIA France VEOLIA France Laboratoire de Biotechnologie de l'Environnement [Narbonne]
• Publié dans Water Science and Technology le 26/10/2020

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Résumé : Two experiments were undertaken in three different experimental set-ups in order to compare them: an industrial 21-m(3) pilot reactor, a new 40-l laboratory pilot reactor and bmp type plasma bottles. Three consecutive batch dry digestion tests of municipal solid waste were performed under mesophilic conditions with the same feedstock in all vessels. Biogas and methane production at the end of the tests were similar (around 200m(3) CH4STP/tVS) for both pilot reactors and were different from the bottle tests. The dynamics of methane production and VFA accumulation concurred. However, the maximal levels of VFA transitory accumulation varied between reactors and between runs in a same reactor. Ammonia levels were similar in both reactors. These results show that the new reactor accurately imitates the conditions found in the larger one. Adaptation of microorganisms to the waste and operating conditions was also pointed out along the consecutive batches. Thermophilic semi-continuous tests were performed in both reactors with similar conditions. The methane production efficiencies were similar.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Andreas ReischJoseph HemmerléJean-Claude VoegelEric GonthierGero DecherNadia Benkirane-JesselArmelle ChassepotDamien MertzPhilippe LavallePhilippe MésiniPierre Schaaf
• Organismes : Institut Charles Sadron Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Institut Charles Sadron Institut Charles Sadron Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Institut Charles Sadron Institut Charles Sadron
• Publié dans Journal of Materials Chemistry le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Pierre RaboissonDominique SchultzChristian MullerJean-Marie ReimundGuillaume PinnaRomain MathieuPhilippe BernardQuoc-Tuan DoRenee DesjarlaisHélène JustianoClaire LugnierJean-Jacques Bourguignon
• Organismes : Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Cooltech Applications Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen] Institut de Biologie Intégrative de la Cellule Centre de Recherches Pétrographiques et Géochimiques Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique
• Publié dans European Journal of Medicinal Chemistry le 31/10/2020

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Résumé : A series of 8-substituted pyrazolo[1,5-a]-1,3,5-triazines were considered as a bioisosteric replacement for the 9-substituted adenine derivatives resulting in the discovery of 8-(2-methoxybenzyl)-4-(N-methylamino)-2-n-propylpyrazolo[1,5-a]-1,3,5-triazine (14d) and 2-trifluoromethyl-8-(2-methoxybenzyl)-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine (14e) as a new structural class of potent phosphodiesterase type 4 inhibitors (IC50 = 13 nM and 11 nM, respectively) with high isoenzyme selectivity. An original tandem of reactions involving a palladium-mediated cross-coupling reaction (PMCCR) of the readily available 8-iodo-2-methyl-4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazine (11a) and arylboronic acids or alkynes followed by the displacement of the N-methyl-N-phenylamino group constitute the key steps in a novel synthetic approach developed herein. The treatment of 11a–c with n-BuLi and selected aldehydes represents an interesting alternative to the PMCCR for the synthesis of benzylic derivatives 14a–i. Preliminary biological testing has shown that compounds 14d and 14e strongly inhibit LPS-induced TNFα release from human mononuclear cells from healthy subjects. These two compounds were selected for further biological evaluation. Some derivatives belonging to the series of pyrazolo[1,5-a]-1,3,5 triazines act as adenine bioisosteres and present potent and selective PDE4 inhibitory properties.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Elodie Françoise VerhaegheAurélien FraysseJean-Luc Guerquin-KernTing-Di WuGuillaume DevèsCharles MioskowskiCatherine LeblancOrtega RYves AmbroisePhilippe Potin
• Organismes : Institut de Biologie et de Technologies de Saclay Chimie Nucléaire Analytique et Bio-environnementale laboratoire de microscopie ionique Imagerie intégrative de la molécule à l'organisme laboratoire de microscopie ionique Imagerie intégrative de la molécule à l'organisme Chimie Nucléaire Analytique et Bio-environnementale Institut de Biologie et de Technologies de Saclay Station biologique de Roscoff [Roscoff] Chimie Nucléaire Analytique et Bio-environnementale Institut de Biologie et de Technologies de Saclay Station biologique de Roscoff [Roscoff]
• Publié dans Journal of Biological Inorganic Chemistry le 31/10/2020

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Résumé : Brown algal kelp species are the most efficient iodine accumulators among all living systems, with an average content of 1.0% of dry weight in Laminaria digitata. The iodine distributions in stipe and blade sections from L. digitata were investigated at tissue and subcellular levels. The quantitative tissue mapping of iodine and other trace elements (Cl, K, Ca, Fe, Zn, As and Br) was provided by the proton microprobe with spatial resolutions down to 2 mum. Chemical imaging at a subcellular resolution (below 100 nm) was performed using the secondary ion mass spectrometry microprobe. Sets of samples were prepared by both chemical fixation and cryofixation procedures. The latter prevented the diffusion and the leaching of labile inorganic iodine species, which were estimated at around 95% of the total content by neutron activation analysis. The distribution of iodine clearly shows a huge, decreasing gradient from the meristoderm to the medulla. The contents of iodine reach very high levels in the more external cell layers, up to 191 +/- 5 mg g(-1) of dry weight in stipe sections. The peripheral tissue is consequently the main storage compartment of iodine. At the subcellular level, iodine is mainly stored in the apoplasm and not in an intracellular compartment as previously proposed. This unexpected distribution may provide an abundant and accessible source of labile iodine species which can be easily remobilized for potential chemical defense and antioxidative activities. According to these imaging data, we proposed new hypotheses for the mechanism of iodine storage in L. digitata tissues.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Bernard NordlingerHalfdan SorbyeBengt GlimeliusGraeme-J. PostonPeter-M. SchlagPhilippe RougierWolf-O. BechsteinJohn-N. PrimroseEuan-T. WalpoleMeg Finch-JonesDaniel JaeckDarius MirzaRowan-W. ParksLaurence ColletteMichel PraetUllrich BetheEric van CutsemWerner ScheithauerThomas GruenbergerJean-Pierre Arnaud
• Organismes : Haukeland University Hospital Uppsala Universitet [Uppsala] Hôpital Européen Georges Pompidou [APHP] Centre de Chirurgie Viscérale, Hépatique et de Transplantation Multiorganes European Organisation for Research and Treatment of Cancer [Bruxelles] Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain Centre Énergétique et Procédés Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques
• Publié dans The Lancet le 02/11/2020

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Résumé :

SummaryBackgroundSurgical resection alone is regarded as the standard of care for patients with liver metastases from colorectal cancer, but relapse is common. We assessed the combination of perioperative chemotherapy and surgery compared with surgery alone for patients with initially resectable liver metastases from colorectal cancer. Methods This parallel-group study reports the trial's final data for progression-free survival for a protocol unspecified interim time-point, while overall survival is still being monitored. 364 patients with histologically proven colorectal cancer and up to four liver metastases were randomly assigned to either six cycles of FOLFOX4 before and six cycles after surgery or to surgery alone (182 in perioperative chemotherapy group vs 182 in surgery group). Patients were centrally randomised by minimisation, adjusting for centre and risk score. The primary objective was to detect a hazard ratio (HR) of 0·71 or less for progression-free survival. Primary analysis was by intention to treat. Analyses were repeated for all eligible (171 vs 171) and resected patients (151 vs 152). This trial is registered with ClinicalTrials.gov, number NCT00006479. Findings In the perioperative chemotherapy group, 151 (83%) patients were resected after a median of six (range 1–6) preoperative cycles and 115 (63%) patients received a median six (1–8) postoperative cycles. 152 (84%) patients were resected in the surgery group. The absolute increase in rate of progression-free survival at 3 years was 7·3% (from 28·1% [95·66% CI 21·3–35·5] to 35·4% [28·1–42·7]; HR 0·79 [0·62–1·02]; p=0·058) in randomised patients; 8·1% (from 28·1% [21·2–36·6] to 36·2% [28·7–43·8]; HR 0·77 [0·60–1·00]; p=0·041) in eligible patients; and 9·2% (from 33·2% [25·3–41·2] to 42·4% [34·0–50·5]; HR 0·73 [0·55–0·97]; p=0·025) in patients undergoing resection. 139 patients died (64 in perioperative chemotherapy group vs 75 in surgery group). Reversible postoperative complications occurred more often after chemotherapy than after surgery (40/159 [25%] vs 27/170 [16%]; p=0·04). After surgery we recorded two deaths in the surgery alone group and one in the perioperative chemotherapy group. Interpretation Perioperative chemotherapy with FOLFOX4 is compatible with major liver surgery and reduces the risk of events of progression-free survival in eligible and resected patients.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2008
• Auteurs : Jean-Pierre CharpyDidier CarnetPhilip BastablePhilippe de La Grange
• Organismes : Centre Interlangues - Texte, Image, Langage Centre Interlangues - Texte, Image, Langage

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Jean-François HanocqMarie WeissJean-Pierre LagouardePhilippe Clastre
• Organismes : Unité mixte de recherche Climat Sol et Environnement Unité mixte de recherche Climat Sol et Environnement Écologie fonctionnelle et physique de l'environnement Unité mixte de recherche Climat Sol et Environnement
• Publié dans Cahier des Techniques de l'INRA le 29/10/2020

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Résumé : Le département Environnement et agronomie de l’Inra a acquis une caméra thermique FLIR–SC2000 pour réaliser le suivi de parcelles agricoles par l’acquisition d’images de température de surface, éventuellement en aéroporté. Les unités EMMAH du centre Inra d'Avignon et EPHYSE du centre Inra de Bordeaux ont effectué sa caractérisation. Afin de pouvoir exploiter correctement ces images, nous avons d'abord été conduits à caractériser précisément la réponse spectrale de la caméra, puis à contrôler sa précision et ses caractéristiques optiques compte tenu de son utilisation dans des environnements et sur des vecteurs très différents (cultures, forêts, serres, avion). Nous décrivons les matériels, les protocoles et les résultats d'expérimentation qui ont servi à la caractériser ; nous abordons également le fonctionnement de ce type de caméra à micro bolomètres dite "non refroidie" où une bonne utilisation du système interne d'auto étalonnage, le "shutter", est importante pour rester dans les limites d’utilisation données par le constructeur.

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Fichiers liés : CT2008_Rayonnements_art09.pdf

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2008
• Auteurs : Renaud AdamPierre AnagnostopoulosSophie BalacePierre-Maurice BogaertSophie ChalleOdile de BruynAnnie de CosterAnne DelvingtPhilippe DesmetteStéphane DetournayClaire DumortierLydie Hadermann-MisguichAlain JacobsPierre-Yves KairisSerge Le Bailly de TilleghemJean-Baptiste LebigueJacqueline Leclercq-MarxIsabelle LecocqMichel LefftzJanette LefrancqEvelien LivensMonique Maillard-LuypaertDidier MartensFrançoise PirenneLucien ReynhoutLuc SerckNoémi ThysFrédéric TixierFrancis TourneurJean-Louis Vanden EyndeCarl van de VeldeJohan van HeeschDominique Vanwijnsberghe
• Organismes : Institut de recherche et d'histoire des textes

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Résumé : I. Du collège des Jésuites au séminaire de Monseigneur Hirn II. Les bâtiments résidentiels, l'église et le jardin III. Les collections : collections archéologiques, archives, manuscrits médiévaux, incunables et imprimés anciens, gravures et estampes, peintures, sculpture, orfèvrerie, vitraux, orgues, céramiques, textiles.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Etienne SamainJonathan WeickPatrick VranckenFranck ParaDominique AlbaneseJocelyn ParisJean-Marie TorreCheng ZhaoPhilippe GuillemotIsabelle Petitbon
• Organismes : Laboratoire Gemini Géoazur Laboratoire Gemini Géoazur Laboratoire Gemini Institut des Matériaux, de Microélectronique et des Nanosciences de Provence Laboratoire Gemini Laboratoire Gemini Laboratoire Gemini Laboratoire Gemini Chinese Academy of Sciences [Changchun Branch] Centre National d'Études Spatiales [Toulouse] Centre National d'Études Spatiales [Toulouse]
• Publié dans International Journal of Modern Physics D le 25/10/2020

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Résumé : The new generation of optical time transfer will allow the synchronization of remote ultra stable clocks and the determination of their performances over intercontinen-tal distances. The principle of T2L2 (Time Transfer by Laser Link) is based on the techniques of satellite laser ranging coupled with time-frequency metrology. It consists of synchronizing ground and space clocks using short laser pulses travelling between ground clocks and satellite equipment. The instrument will be integrated on the ocean altimetry satellite Jason-2 that is scheduled for launch in 2008. a The experiment should enhance the performance of time transfer by one or two magnitudes compared to existing microwave techniques such as GPS and Two-Way Satellite Time and Frequency Transfer (TWSTFT).

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Fichiers liés : 2008_International Journal of Modern Physics D.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Gabriel VasileEmmanuel TrouvéIvan PetillotPhilippe BolonJean-Marie NicolasMichel GayJocelyn ChanussotTania LandesP. GrussenmeyerVasile BuzuloiuIrena HajnsekChristian AndresMartin KellerRalf Horn
• Organismes : Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Département Traitement du Signal et des Images GIPSA-Services GIPSA - Signal Images Physique GIPSA - Signal Images Physique Equipe Photogrammétrie et Géomatique Equipe Photogrammétrie et Géomatique Laboratorul de Analiza si Prelucrarea Imaginilor [Bucarest] German Aerospace Center German Aerospace Center German Aerospace Center German Aerospace Center
• Publié dans IEEE Transactions on Geoscience and Remote Sensing le 31/10/2020

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Résumé : Synthetic aperture radar (SAR) interferometric data offer the opportunity to measure temperate glacier surface topography and displacement. The increase of the resolution provided by the most recent SAR systems has some critical implications. For instance, a reliable estimate of the phase gradient can only be achieved by using interferogram local frequencies. In this paper, an original two-step method for estimating local frequencies is proposed. The 2-D phase signal is considered to have two deterministic components corresponding to low-resolution (LR) fringes and high-resolution (HR) patterns due to the local microrelief, respectively. The first step of the proposed algorithm consists in the LR phase flattening. In the second step, the local HR frequencies are estimated from the phase 2-D autocorrelation function computed on adaptive neighborhoods. This neighborhood is the set of connected pixels belonging to the same HR spatial feature and respecting the "local stationarity" hypothesis. Results with both simulated TerraSAR-X interferograms and real airborne E-SAR images are presented to illustrate the potential of the proposed method.

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Fichiers liés : ieee_tgars_08_vasile_sar_interfero.pdf

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