Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 15/05/2006
• Auteurs : Jacqueline CapeauMartine CaronCorinne VigourouxPascale CerveraMin Ji KimMustapha MaachiClaire LagathuJean-Philippe Bastard
• Organismes : Pathologie de l'Adipocyte et des Cellules Hepatiques
• Publié dans Médecine/Sciences le 25/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 15/05/2006
• Auteurs : Jérôme PoulenardAmandine JacquierFlorent PezetLaetitia RocheJérôme LazzarottoJ-Pierre BosseAnnie MilleryDominique TrevisanJean Marcel DoriozP. Quétin
• Organismes : Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Université Savoie Mont Blanc Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Université Savoie Mont Blanc Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Université Savoie Mont Blanc Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Université Savoie Mont Blanc Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Université Savoie Mont Blanc Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques

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• Type de publi. : Communication dans un congrès
• Date de publi. : 15/05/2006
• Auteurs : Kauzar Saleh ContellWigneron J.-P.Patricia de RosnayJean-Christophe CalvetYann H. KerrMaria Jose EscorihuelaPhilippe Waldteufel
• Organismes : Écologie fonctionnelle et physique de l'environnement Department of Geography [Cambridge, UK] Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère Météo-France Direction Interrégionale Sud-Est Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Service d'aéronomie

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Fichiers liés : 17340_20070920124055921_1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 15/05/2006
• Auteurs : Christian MorhainJean-Michel ChauveauM. TeisseireB. LoM. LaügtPhilippe VennéguèsXiaodong TangB. VinterChristiane DeparisThierry BretagnonPierre LefebvreBernard Gil
• Organismes : Centre de recherche sur l'hétéroepitaxie et ses applications Centre de recherche sur l'hétéroepitaxie et ses applications Centre de recherche sur l'hétéroepitaxie et ses applications Centre de recherche sur l'hétéroepitaxie et ses applications Centre de recherche sur l'hétéroepitaxie et ses applications Centre de recherche sur l'hétéroepitaxie et ses applications Centre de recherche sur l'hétéroepitaxie et ses applications Centre de recherche sur l'hétéroepitaxie et ses applications Centre de recherche sur l'hétéroepitaxie et ses applications Groupe d'étude des semiconducteurs Groupe d'étude des semiconducteurs Groupe d'étude des semiconducteurs

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• Type de publi. : Communication dans un congrès
• Date de publi. : 14/05/2006
• Auteurs : Alexandre SkrzypczackPierre SiohanJean-Philippe Javaudin
• Organismes : Institut d'Electronique et de Télécommunications de Rennes France Télécom Recherche & Développement France Télécom Recherche & Développement

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 12/05/2006
• Auteurs : Philippe LeiningerJean-Pascal RueffJ.-M. MariotA. YareskoO. ProuxJean-Louis F HazemannG. VankoT. SasakiH. Ishii
• Organismes : Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Max-Planck-Institut für Physik komplexer Systeme European Synchrotron Radiation Facility Laboratoire de Cristallographie European Synchrotron Radiation Facility Institute for Materials Research [Tohoku University] National Synchrotron Radiation Research Center

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Résumé : The electronic properties of Co in bulk Na0.7CoO2 and the superconducting hydrated compound Na0.35CoO2 - y H2O have been investigated by x-ray absorption spectroscopy (XAS) and resonant inelastic x-ray scattering (RIXS) using hard x-rays. The XAS spectra at the Co K-edge were measured in both compounds with two different polarization directions. The changes in the XAS spectra upon hydration and their polarization dependence are well accounted for by linear muffin- tin orbital calculations in the local density approximation. The underlying electronic structure indicates the strong hybridization between the Co 3d and O 2p states in both compounds, while the electron localization is enhanced in the hydrated compound due to the increase of the Co-Co interplanar distance. The Co K pre-edge further highlights the splitting of the d band as a result of the crystal field effect and demonstrates the Co valency increase when Na0.7CoO2 is hydrated. The RIXS spectra measured at the Co K-edge show an energy loss feature around 10 eV in both compounds in fair agreement with the calculated dynamical structure factor. The RIXS feature is associated to a damped plasmon excitation.

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Fichiers liés : publication.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/05/2006
• Auteurs : Alexandre SkrzypczackJean-Philippe JavaudinPierre Siohan
• Organismes : Institut d'Electronique et de Télécommunications de Rennes France Télécom Recherche & Développement France Télécom Recherche & Développement

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• Type de publi. : Article dans une revue
• Date de publi. : 03/05/2006
• Auteurs : Stéphane RigautCéline OlivierKarine CostuasSylvie ChouaOmrane FadhelJulien MassuePhilippe TurekJean-Yves SaillardPierre H. DixneufDaniel Touchard
• Organismes : Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut Charles Sadron Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut Charles Sadron Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes Institut des Sciences Chimiques de Rennes
• Publié dans Journal of the American Chemical Society le 30/10/2020

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Résumé : Two methodologies of C-C bond formation to achieve organometallic complexes with 7 or 9 conjugated carbon atoms are described. A C7 annelated trans-[Cl(dppe)2Ru=C=C=C-CH=C(CH2)-C[triple bond]C-Ru(dppe)2Cl][X] (X = PF6, OTf) complex is obtained from the diyne trans-[Cl(dppe)2Ru-(C[triple bond]C)2-R] (R = H, SiMe3) in the presence of [FeCp2][PF6] or HOTf, and C7 or C9 complexes trans-[Cl(dppe)2Ru-(C[triple bond]C)n-C(CH3)=C(R1)-C(R2)=C=C=Ru(dppe)2Cl][X] (n = 1, 2; R1 = Me, Ph, R2 = H, Me; X = BF4, OTf) are formed in the presence of a polyyne trans-[Cl(dppe)2Ru-(C[triple bond]C)n-R] (n = 2, 3; R = H, SiMe3) with a ruthenium allenylidene trans-[Cl(dppe)2Ru=C=C=C(CH2R1)R2][X]. These reactions proceed under mild conditions and involve cumulenic intermediates [M+]=(C=)nCHR (n = 3, 5), including a hexapentaenylidene. A combination of chemical, electrochemical, spectroscopic (UV-vis, IR, NIR, EPR), and theoretical (DFT) techniques is used to show the influence of the nature and conformation of the bridge on the properties of the complexes and to give a picture of the electron delocalization in the reduced and oxidized states. These studies demonstrate that the C7 bridging ligand spanning the metal centers by almost 12 angstroms is implicated in both redox processes and serves as a molecular wire to convey the unpaired electron with no tendency for spin localization on one of the halves of the molecules. The reactivity of the C7 complexes toward protonation and deprotonation led to original bis(acetylides), vinylidene-allenylidene, or carbyne-vinylidene species such as trans-[Cl(dppe)2Ru[triple bond]C-CH=C(CH3)-CH=C(CH3)-HC=C=Ru(dppe)2Cl][BF4]3.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/05/2006
• Auteurs : C. Camy-PeyretSébastien PayenPascal PrunetEmmanuel DufourRoger BruggeAlan O'NeillJean GirouxPhilippe Lagueux
• Organismes : Laboratoire de Physique Moleculaire pour l'Atmosphere et l'Astrophysique Laboratoire de Physique Moleculaire pour l'Atmosphere et l'Astrophysique NOVELTIS [Sté] NOVELTIS [Sté] University of Reading University of Reading

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Résumé : Because of their high spectral resolution (0.035 cm-1 unapodised), MIPAS spectra contain potential information on the Doppler shifts due to wind along the line-of-sight (LOS) in a given limb scan sequence. The intrinsic absolute stability of the MIPAS wavenumber scale is not granted to the required precision, however. The present ESA operational spectral calibration algorithm is relying on the position of the atmospheric emission lines themselves (assuming no wind effect and in a small range of tangent altitudes where lines are neither too broadened by pressure effects, nor too weak). An algorithm has been proposed that just relies on the relative stability of the wavenumber scale within a given limb scan sequence (usually 17 spectra recorded from about 65 to 10 km in approximately 75 s) to derive a vertical LOS relative wind profile. This LOS wind information is derived by an appropriate algorithm called ANA (for analytical method because an explicit formula is used) producing a wavenumber scaling factor between consecutive spectra in a given limb scan. This scaling factor is derived from a number of optimised wind spectra windows spanning the 5 bands covered by MIPAS. Because of the relative nature of the process, the absolute interband/interwindow calibration is not needed and an optimum weighted average value of the scaling factors can be derived with weights (and an associated occupation matrix) representing the impact of radiometric noise in each window w and for each pair of tangent heights. The average scaling factor is then converted to a relative LOS wind difference and, assuming the LOS wind is known at one level, an absolute LOS wind profile can be provided. The algorithm has been developed (through an ESA contract study), coded and tested on simulated spectra (to check the performances of the method and to establish the noise amplification error factors). We are in the process of testing the algorithm on a set of selected MIPAS spectra recorded in correlation with standard meteorological radio- soundings (providing T, u and v as a function of P). Preliminary results of this study will be presented including comparisons with ECMWF and sonde results, showing that a precision reaching the target of 5 m/s could be expected in the altitude range 20 to 35 km.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2006
• Auteurs : Agnès GoubleJulianne SmithSylvia BruneauChristophe PerezValérie GuyotJean‐pierre CabaniolsSophie LeducLaurence FiettePatrick AvéBéatrice MicheauPhilippe DuchateauFrédéric Pâques
• Organismes : Cellectis Cellectis Cellectis Cellectis Cellectis Cellectis Cellectis Histotechnologie et Pathologie Histotechnologie et Pathologie Cellectis Cellectis Cellectis
• Publié dans The Journal of Gene Medicine le 25/10/2020

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Résumé : Background Sequence‐specific endonucleases with large recognition sites can cleave DNA in living cells, and, as a consequence, stimulate homologous recombination (HR) up to 10 000‐fold. The recent development of artificial meganucleases with chosen specificities has provided the potential to target any chromosomal locus. Thus, they may represent a universal genome engineering tool and seem to be very promising for acute gene therapy. However, in toto applications depend on the ability to target somatic tissues as well as the proficiency of somatic cells to perform double‐strand break (DSB)‐induced HR. Methods In order to investigate DSB‐induced HR in toto , we have designed transgenic mouse lines carrying a LagoZ gene interrupted by one I‐ Sce I cleavage site surrounded by two direct repeats. The LagoZ gene can be rescued upon cleavage by I‐ Sce I and HR between the two repeats in a process called single‐strand annealing. β‐Galactosidase activity is monitored in liver after tail vein injection of adenovirus expressing the meganuclease I‐SceI. Results In toto staining revealed a strong dotted pattern in all animals injected with adenovirus expressing I‐SceI. In contrast, no staining could be detected in the control. β‐Galactosidase activity in liver extract, tissue section staining, and PCR analysis confirmed the presence of the recombined LagoZ gene. Conclusions We demonstrate for the first time that meganucleases can be successfully delivered in animal and induce targeted genomic recombination in mice liver in toto . These results are an essential step towards the use of designed meganucleases and show the high potential of this technology in the field of gene therapy. Copyright © 2006 John Wiley & Sons, Ltd.

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