Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2000
• Auteurs : Philippe BiaginiHoussam AttouiPierre GallianMhammed TouinssiJean-François CantaloubePhilippe de MiccoXavier de Lamballerie
• Organismes : Virologie UMR1161
• Publié dans Biochemical and Biophysical Research Communications le 28/10/2020

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/05/2000
• Auteurs : Philippe Jean-PierreMichel Beine
• Organismes : Centre d'Économie et de Management de l'Océan Indien Université de La Réunion Université du Luxembourg = University of Luxembourg = Universität Luxemburg

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2000
• Auteurs : Christophe RostyJosette BrièreChristophe CellierEric DelabesseFrançoise CarnotJean-Philippe BarbierPierre Laurent-Puig
• Organismes : Laboratoire d'Hématologie, Hôpital Necker
• Publié dans Modern Pathology le 23/10/2020

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Résumé : Hereditary nonpolyposis colorectal cancer (HNPCC) is an inherited predisposition to colorectal and endometrial cancers caused by germline mutation of mismatch repair genes, with hMLH1 and hMSH2 underlying the majority of the cases. Although lymphoid tumors are the most common tumors in mouse models for HNPCC, lymphomas are almost never encountered in patients who have HNPCC, except in rare families with germline homozygous deletion of hMLH1. We report the case of a 53-year-old man who had a history of colon cancers related to constitutional hMLH1 mutation and who was diagnosed as having a duodenal follicular lymphoma This diagnosis was supported by IgH-BCL2 rearrangement and BCL2 immunoreactivity in tumor cells. The association of both of these possibly related rare diseases has never been reported. To clarify this relationship, we searched for hMLH1 expression and mismatch repair deficiency in the duodenal lymphoma. hMLH1 immunostaining was positive in lymphoid tumor cells, and no microsatellite instability was detected. In agreement with mouse models for HNPCC, these results suggest the involvement of alternative mechanisms to complete mismatch repair deficiency for lymphomagenesis in HNPCC syndrome.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2000
• Auteurs : Olivier MarchèsJean-Philippe NougayrèdeSéverine BoullierJacques MainilGérard CharlierIsabelle RaymondPierre PohlMichèle BouryJean de RyckeAlain MilonEric Oswald
• Organismes : Institut de Recherche en Santé Digestive
• Publié dans Infection and Immunity le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2000
• Auteurs : Joseph MartinodDenis HatzfeldPhilippe DavyPierre GautierJean-Pierre Brun
• Organismes : Géosciences Environnement Toulouse Laboratoire de Géodynamique des Chaines Alpines Géosciences Rennes Géosciences Rennes
• Publié dans Tectonics le 22/10/2020

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Résumé : We have carried out experiments using a layered medium of sand and silicone to investigate the lateral extrusion of a material which spreads over its own weight while being compressed by the advance of a rigid indenter. Boundary conditions in the box mimic those prevailing in the Anatolian-Aegean system. Both shortening in front of the rigid piston, which models the northward motion of Arabia, and extension resulting from the gravity spreading of the sand-silicone layer are necessary to initiate the lateral extrusion. Strike-slip faults accommodate the lateral escape and link the normal faults accompanying gravity spreading with the thrust faults in front of the rigid indenter. Strike-slip faults begin to accommodate extrusion at a late stage in the experiments after the normal and thrust faults have developed. Experiments also show that the initial geometry of the boundary of the spreading layer may result in the formation of two arcs behind which material extends, in a manner analogous to the Hellenic and Cypriot arcs, without invoking a rheological change at the junction of the two arcs. The experiments also suggest that southward motion of the eastern part of the spreading region is compensated by the northward advance of the piston, which is a possible explanation for the slower movement of the Cypriot arc compared to the Aegean arc.

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Fichiers liés : Aegea-Anatolia-HAL-2000.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2000
• Auteurs : M. BadilaG. BrezeanuJosé del R. MillánPhilippe GodignonMarie-Laure LocatelliJean-Pierre ChanteA. A. LebedevP. LunguG. DincaViorel BanuG. Banoiu
• Organismes : Centro Nacional de Microelectronica [Spain] Centre de génie électrique de Lyon Centre de génie électrique de Lyon
• Publié dans Diamond and Related Materials le 01/11/2020

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Résumé : A silicon carbide Schottky UV detector technology is proposed. The Au Schottky contact is delimited using lift-off technology. The contact window was open into a sandwich of SiO2 oxides in order to produce a small angle ramp that constitutes the dielectric part of the Schottky diode termination. The I-V and C-V characteristics measured under dark and illuminated UV irradiation conditions indicate a significant sensitivity with UV radiation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2000
• Auteurs : Jean-Philippe HaymannJean-Pierre LevraudSandrine BouetVincent KappèsJacqueline HagègeGenevieve NguyenYichun XuEric RondeauJean-Daniel Sraer
• Organismes : U489 Inserm [CHU Tenon, APHP] Biologie Moléculaire du Gène U489 Inserm [CHU Tenon, APHP] U489 Inserm [CHU Tenon, APHP] U489 Inserm [CHU Tenon, APHP] U489 Inserm [CHU Tenon, APHP] U489 Inserm [CHU Tenon, APHP] U489 Inserm [CHU Tenon, APHP] U489 Inserm [CHU Tenon, APHP]
• Publié dans Journal of the American Society of Nephrology le 26/10/2020

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Résumé : The binding of Fc fragments of Ig on glomerular epithelial cells (GEC) was observed previously, but the receptor could not be identified. In immunofluorescence and immunohistochemical studies using normal adult human kidney sections, the presence of the so-called neonatal Fc receptor (FcRn) was demonstrated on GEC as well as in the brush border of proximal tubular cells. FcRn transcripts were also detected on isolated glomeruli by reverse transcription-PCR. Using an immortalized GEC line, the presence of the FcRn was confirmed by flow cytometry, reverse transcription-PCR, Western blotting, and by the pH dependence of the binding of heat-aggregated IgG. Because it is well established that the FcRn is involved in IgG transcytosis, it is hypothesized that the FcRn in the kidney may play a role in the reabsorption of IgG. Ongoing studies should clarify the role of the FcRn as a potential target for immune complexes on GEC and should assess its relevance in physiology and pathology.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2000
• Auteurs : Céline PagèsAlexia GirardOlivier JeannetonPierre BarbeClaude WolfMax LafontanPhilippe P. ValetJean Sébastien Saulnier-Blache
• Organismes : Biologie de l'adipocyte, physiologie du tissu adipeux et obésités Biologie de l'adipocyte, physiologie du tissu adipeux et obésités Biologie de l'adipocyte, physiologie du tissu adipeux et obésités Biologie de l'adipocyte, physiologie du tissu adipeux et obésités AP-HP - Hôpital Saint-Antoine Biologie de l'adipocyte, physiologie du tissu adipeux et obésités Biologie de l'adipocyte, physiologie du tissu adipeux et obésités Biologie de l'adipocyte, physiologie du tissu adipeux et obésités
• Publié dans Annals of the New York Academy of Sciences le 01/11/2020

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Résumé : Adipogenesis corresponds to the recruitment of new adipocytes in adipose tissue, and results from the proliferation/differentiation of preadipocytes. Production of paracrine and autocrine factors by adipocytes plays an important role in adipogenesis. We recently demonstrated the existence of adipocyte production of lysophosphatidic acid (LPA) both in vitro and in situ. This production is modulated by catecholamines via alpha 2-adrenergic receptors. Adipocyte-LPA present in conditioned media increases the growth of a preadipose cell line in culture. This growth is associated with an activation of mitogen-activated protein kinases, and of the focal adhesion kinase. Because of the close proximity of preadipocytes and adipocytes within adipose tissue, adipocyte-LPA could play an important role in autocrine/paracrine control of adipogenesis.

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Fichiers liés : Pages_et_al._NY_Ac.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2000
• Auteurs : G. BrezeanuM. BadilaB. TudorPhilippe GodignonJosé del R. MillánMarie-Laure LocatelliJean-Pierre ChanteA. A. LebedevN. S. Savkina
• Organismes : Centro Nacional de Microelectronica [Spain] Centre de génie électrique de Lyon Centre de génie électrique de Lyon
• Publié dans Solid-State Electronics le 22/10/2020

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Résumé : New models for the high frequency capacitance-voltage, C(V) and forward curreat-voltage, I-F(V-F) characteristics of a large area 6H-SiC boron compensated pn junction have been developed and implemented in an optimal parameter extraction program. The C(V) model and SIMS measurements confirm the presence of two type regions (p(-) and n(-)) in the quasi-intrinsic layer induced by boron doping. The extracted values of the net doping of these zones (6-10 x 10(12) cm(-3)) are in good agreement with previously reported data. In contrast, the thickness of the quasi-intrinsic layer, about twice the epilayer width, proves the expansion of the quasi-intrinsic region in the substrate. The I-F(V-F) modeling includes a square law dependence of the forward current on VF, at high injection level. For the first time in the literature, saturation currents of SIC pn diodes is reported. The extracted saturation currents increase linearly with area, evidencing the beneficial effect of boron diffusion for obtaining predictable large area devices. The temperature behavior is also investigated. At high temperatures, the boron compensation effect is reduced.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/03/2000
• Auteurs : Jean-Pierre LefebvrePhilippe LasayguesSerge MensahSébastien DelamareArmand Wirgin
• Organismes : Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille]

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