Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Anne-Laure MorinEmmanuelle BlancArmelle PhaliponPierre-Henri BertoyePhilippe AmielCécile ArtaudPhilippe BarthélemyElisabeth Botelho-NeversSoizic CourcierJean-Luc CracowskiFrançois EisingerRemi ForratAlina GruberEuzebiusz JamrozikOdile LaunayClaire Le JeunneDavid Simhon
• Organismes : Institut Pasteur [Paris] Pfizer Institut Pasteur [Paris] Ministère des Solidarités et de la Santé [Paris, France] Institut National de la Santé et de la Recherche Médicale AstraZeneca AP-HP - Hôpital Antoine Béclère [Clamart] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpital Michallon Institut Paoli-Calmettes Sanofi-Aventis R&D GlaxoSmithKline University of Oxford Monash university CIC - Vaccinologie - APHP (Cochin - Pasteur) F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Hôpital Cochin [AP-HP] Galien Affaires [Paris]
• Publié dans Therapies le 04/10/2022

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Résumé : This round table is the result of an observation. The observation being that controlled human infection clinical trials (also called "infectious challenge" trials or "Controlled Human Infection Models", "CHIM") recommended or even encouraged in the context of vaccine developments in particular, are not carried out in France. However, there are no formal prohibitions within regulations or ethical principles, which point to the prior assessment of risks and benefits for individuals and for society. The participants in this Round Table thus wished to examine, through the prism of their respective disciplines, the scientific and medical relevance of conducting such trials in France and, if possible, to imagine the conditions under which they would be carried out, thus resulting in recommendations on (1) the advisability of their conduct in France (2), the conditions under which they would be implemented in terms of logistics and regulations, and (3) their social acceptability. The recommendations on which the participants of the Round Table came to an agreement are presented as the analysis progresses.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Sophie LarocheChetana LimClaire GoumardMichel RayarDaniel CherquiLaurence ChicheLouise BarbierEphrem SalaméJean-Yves MabrutMickael LesurtelStéphanie TruantEmmanuel BoleslawskiFabrice MuscariChristian HobeikaMircea ChiricaEmmanuel BucJean HardwigsenAstrid HerreroFrancis NavarroFrançois FaitotPhilippe BachellierJean-Marc RégimbeauAlexis LaurentDavid FuksOlivier SoubraneDaniel AzoulayEric VibertOlivier ScattonFrancois CauchyTakeo NomiNassima OudafalBrice GayetTakayuki KawaiShohei KomatsuShinya OkumuraNicolo PetruccianiPetru O. BucurBoris TrechotJulio NunezMichele TedeschiMarc-Antoine AllardNicolas GolseOriana CiacioGabriella PittauAntonio CunhaRene AdamChristophe LaurentPauline LéourierLionel RebiboLorenzo FerreFrancois-Regis SoucheJohn ChauvatFrancois JehaesKayvan MohkamThevy HorFrancois PayePierre BalladurBertrand SucGuillaume MilletMehdi El AmraniCeline RatajczakKatia LecolleFrancois-Rene PruvotAli-Reza KianmaneshTatiana CodjiaLilian SchwarzEdouard GirardJulio AbbaChristian LetoublonAhmed BourasAntoine CarmeloCharles VanbruggheZineb CherkaouiXavier UnterteinerPatrick PessauxRiccardo MemeoEmilie LhermiteMarie BougardJulien BarbieuxUgo MarcheseJacques EwaldOlivier TuriniAlexandre ThobieBenjamin MenahemAndrea MulliriJean LubranoJohanna ZemourHerve FagotGuillaume PassotEmilie GregoireYves Le TreutDavid Patrice
• Organismes : CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Simplification des soins chez les patients complexes - UR UPJV 7518 Centre de Recherche Saint-Antoine Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hépato-Biliaire [Hôpital Paul Brousse] Hôpital Haut-Lévêque - CHU de Bordeaux Hôpital Haut-Lévêque - CHU de Bordeaux Centre Hospitalier Régional Universitaire de Tours Hôpital de la Croix-Rousse [CHU - HCL] Service de chirurgie hepato-pancreato-biliaire Service de chirurgie hepato-pancreato-biliaire Hôpital Claude Huriez [Lille] Chirurgie Générale et Digestive [Rangueil] Service de chirurgie hepato-pancreato-biliaire Département d'hépato-gastroentérologie Service Chirurgie Digestive et Hépatobiliaire [CHU Clermont-Ferrand] Service chirurgie générale et transplantation hépatique, APHM, Hôpital La Timone, Marseille, France Département d'Hépato-Gastroentérologie et de Transplantation Hépatique [CHU Saint-Eloi] Département d'Hépato-Gastroentérologie et de Transplantation Hépatique [CHU Saint-Eloi] Hôpital de Hautepierre [Strasbourg] Hôpital de Hautepierre [Strasbourg] Chirurgie digestive [CHU Amiens] Simplification des soins chez les patients complexes - UR UPJV 7518 Service de chirurgie digestive Hôpital Cochin [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut Mutualiste de Montsouris Centre Hépato-Biliaire [Hôpital Paul Brousse] Centre Hépato-Biliaire [Hôpital Paul Brousse] CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche Saint-Antoine
• Publié dans HPB le 26/10/2020

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Résumé : Background: There are no data to evaluate the difference in populations and impact of centers with liver transplant programs in performing laparoscopic liver resection (LLR). Methods: This was a multicenter study including patients undergoing LLR for benign and malignant tumors at 27 French centers from 1996 to 2018. The main outcomes were postoperative severe morbidity and mortality. Results: A total of 3154 patients were included, and 14 centers were classified as transplant centers (N = 2167 patients, 68.7 %). The transplant centers performed more difficult LLRs and more resections for hepatocellular carcinoma (HCC) in patients who more frequently had cirrhosis. A higher rate of performing the Pringle maneuver, a lower rate of blood loss and a higher rate of open conversion (all p < 0.05) were observed in the transplant centers. There was no association between the presence of a liver transplant program and either postoperative severe morbidity (<10 % in each group; p = 0.228) or mortality (1 % in each group; p = 0.915). Conclusions: Most HCCs, difficult LLRs, and cirrhotic patients are treated in transplant centers. We show that all centers can achieve comparable safety and quality of care in LLR independent of the presence of a liver transplant program.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Laura PolivkaMarine MadrangeCristina Bulai-LivideanuStéphane BareteThomas BallulAntoine NeurazCeline GrecoJulie AgopianFabienne BrenetPatrice DubreuilCharles BurdetRichard LemalOlivier TournilhacLouis TerriouDavid LaunayLaurence BouilletClément GourguechonGhandi DamajLaurent FrenzelCécile MeniHassiba BouktitAnne Florence CollangeCaroline Gaudy-MarquesteMarie GousseffEdwige Le MouelMohamed HamidouAntoine NéelDana RantaRoland JaussaudPhilippe GuilpainDanielle CanioniThierry Jo MolinaJulie BruneauLudovic LhermitteNicolas GarcelonRose-Marie JavierFabien PelletierFlorence CastelainFrederique RetornazQuentin CabreraPatricia ZunicMarie Pierre GourinEwa Hainaut-WierzbickaJean François ViallardChristian LavigneCyrille HoarauIsabelle DurieuMaël HeibligSophie Dimicoli-SalazarJosé Miguel Torregrosa-DiazAngèle SoriaMichel ArockOlivier LortholaryChristine BodemerOlivier HermineJulien Rossignol
• Organismes : Translational Research in Autoimmunity and Inflammation Group Centre de Recherche en Cancérologie de Marseille
• Publié dans Journal of Allergy and Clinical Immunology le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Pierre-Régis BurgelKevin SouthernCharlotte AddyAlberto BattezzatiClaire BerryJean-Philippe BoucharaEdwin BrokaarWhitney BrownPilar AzevedoIsabelle DurieuMiquel EkkelenkampFelicity FinlaysonJulian FortonJohanna GardeckiPavla HodkovaGina HongJacqueline LowdonSu MadgeClémence MartinEdward MckoneAnne MunckChee OoiLucy PerremAmanda PiperAndrew PrayleFelix RatjenMargaret RosenfeldDon SandersCarsten SchwarzGiovanni TaccettiClaire WainwrightNatalie WestMichael WilschanskiAmanda BevanCarlo CastellaniPavel DrevinekSilvia GartnerAndrea GramegnaElise LammertynBarry PlantAlan SmythSilke van Koningsbruggen-RietschelPeter Middleton
• Organismes : Institut Cochin Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Centre Hospitalier Universitaire d'Angers Research on Healthcare Performance Hospices Civils de Lyon Institut Cochin
• Publié dans Journal of Cystic Fibrosis le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Valentin FerrerAndré RicardJ P GardouF. MarchalJ. AmorimJean-Philippe Sarrette
• Organismes : Plasmas Réactifs Hors Equilibre Plasmas Réactifs Hors Equilibre Plasmas Réactifs Hors Equilibre Plasmas Réactifs Hors Equilibre Universidade Federal Fluminense [Rio de Janeiro] Plasmas Réactifs Hors Equilibre
• Publié dans Chemical Physics Letters le 27/10/2020

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Fichiers liés : pre proof.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Ana Bendejacq-SeychellesStéphanie Gibot-LeclercJean-Philippe GuilleminGregory MouilleChristian Steinberg
• Organismes : Agroécologie [Dijon] Agroécologie [Dijon] Agroécologie [Dijon] Institut Jean-Pierre Bourgin - Sciences du végétal Agroécologie [Dijon]
• Publié dans Pest Management Science le 31/10/2020

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Résumé : Among the alternatives to synthetic plant protection products, biocontrol appears as a promising method. This review reports on the diversity of fungal secondary metabolites phytotoxic to weeds and on the approach generally used to extract, characterize, identify and exploit them for weed management. The 183 phytotoxic fungal secondary metabolites discussed in this review fall into five main classes of molecules: 61 polyketides, 53 terpenoids, 36 nitrogenous metabolites, 18 phenols and phenolic acids, and 15 miscellaneous. They are mainly produced by the genera Drechslera, Fusarium and Alternaria. The phytotoxic effects, more often described by the symptoms they produce on plants than by their mode of action, range from inhibition of germination to inhibition of root and vegetative growth, including tissue and organ alterations. The biochemical characterization of fungal secondary metabolites requires expertise and tools to carry out fungal cultivation and metabolite extraction, phytotoxicity tests, purification and fractionation of the extracts, and chemical identification procedures. Phytotoxicity tests are mainly carried out under controlled laboratory conditions (not always on whole plants), while effectiveness against targeted weeds and environmental impacts must be assessed in greenhouses and open fields. These steps are necessary for the formulation of effective, environment-friendly fungal secondary metabolites-derived bioherbicides using new technologies such as nanomaterials.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Halima KhadraouiChunchesh Malangi GajendramurthySara Figueirêdo de Alcântara MoraisYann CornatonHédi M’rabetPhilippe BertaniAïcha ArfaouiJean-Pierre Djukic
• Organismes : Institut de Chimie de Strasbourg Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar) Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar) Institut de Chimie de Strasbourg Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar) Institut de Chimie de Strasbourg
• Publié dans Organometallics le 02/11/2020

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Résumé : This study addresses the chemoselectivity of the catalyzed reduction of a series of variously substituted γ-lactams by Et₃SiH mediated by a pentamethylcyclopentadienyl iridacyclic acetonitrilo salt derived from benzo[h]quinoline. Introduction of an unsaturation within the 5-membered ring of the γ-lactam annihilates the precedence of the amide function over the capture of the silylium cation, which results in a lower chemoselectivity. Monitoring over time the catalyzed reduction of a γ-lactam bearing a carboxylic ester appendage by 1H NMR spectroscopy revealed pseudo-zero-order kinetics for the prior hydrosilylation of the lactam’s amide. This primary hydrosilylation reaction is followed by the full conversion of the formed intermediate into a pyrrolidine following a pseudo-first-order rate law. Under anhydrous conditions, the hydrosilylation of the pendant ester function occurs only in a late stage once the γ-lactam’s amide function has underwent full reduction of the carbonyl function. DFT investigations show that chemoselectivity is governed (1) by the affinity of the organic substrate for the triethylsilylium cation produced by the electrophilic activation of Et3SiH by the Ir(III) catalyst and (2) by the ability of the in situ-formed hydrido-iridium(III) intermediate to transfer hydride to the activated substrate.

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Fichiers liés : Manuscrit_R2v3_HAL.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/01/2024
• Auteurs : Eric SauquetGuillaume EvinSonia SiauveAudrey Bornancin-PlantierNatacha JacquinPatrick ArnaudMaud BerelSébastien BernusJeremie BonneauFlora BrangerYvan CaballeroFrançois ColleoniLila ColletLola CorreAgathe DrouinAgnès DucharneMaïté FournierJoël GailhardFlorence HabetsFrédéric HendrickxLouis HérautBenoît HingrayPeng HuangTristan JaouenAlexis JeantetSandra LaniniMatthieu Le LaySarah LoudinClaire MagandPaula MarsonLouise MimeauCéline MonteilSimon MunierCharles PerrinYoann RobinFabienne RoussetJean-Michel SoubeyrouxLaurent StrohmengerGuillaume ThirelFlore TocquerYves TramblayJean-Pierre VergnesJean-Philippe VidalMathieu Vrac
• Organismes : RiverLy - Fonctionnement des hydrosystèmes Institut des Géosciences de l’Environnement Risques gravitaires et cryosphère en montagne Office International de l'Eau Office International de l'Eau Office International de l'Eau Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience Ministère de la transition énergétique et de la cohésion des territoires Météo-France Déchets Eaux Environnement Pollutions RiverLy - Fonctionnement des hydrosystèmes RiverLy - Fonctionnement des hydrosystèmes Bureau de Recherches Géologiques et Minières Université de Montpellier Gestion de l'Eau, Acteurs, Usages Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience Optimisation, Simulation, Risque et Statistiques pour les Marchés de l’Energie Météo-France Météo-France Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols ACTEON Direction Technique Laboratoire de géologie de l'ENS Laboratoire National d’Hydraulique et Environnement RiverLy - Fonctionnement des hydrosystèmes Institut des Géosciences de l’Environnement Sorbonne Université RiverLy - Fonctionnement des hydrosystèmes Centre national de recherches météorologiques Bureau de Recherches Géologiques et Minières EDF - Division Technique Générale ACTEON Office français de la biodiversité Météo-France RiverLy - Fonctionnement des hydrosystèmes Laboratoire National d’Hydraulique et Environnement Centre national de recherches météorologiques Hydrosystèmes continentaux anthropisés : ressources, risques, restauration Institut Pierre-Simon-Laplace Météo-France Météo-France Hydrosystèmes continentaux anthropisés : ressources, risques, restauration Hydrosystèmes continentaux anthropisés : ressources, risques, restauration Météo-France UMR 228 Espace-Dev, Espace pour le développement Bureau de Recherches Géologiques et Minières RiverLy - Fonctionnement des hydrosystèmes Institut Pierre-Simon-Laplace

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Résumé : Ce document résume les principales conclusions sur l'évolution de variables climatiques et hydrologiques (surface et souterrain) et des aléas hydroclimatiques, obtenues à l'issue du projet Explore2. Il s'achève par des messages et enseignements du projet Explore2 sur le volet scientifique et le volet accompagnement des acteurs.

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Fichiers liés : Explore2_Messages_VF.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Roel AaijAhmed Sameh Wagih AbdelmottelebCarlos Abellan BetetaFernando Jesus AbudinénThomas AckernleyAyomide Matthew AdefisoyeBernardo AdevaMarco AdinolfiPatrik Harri AdlarsonChristina AgapopoulouChristine Angela AidalaZiad AjaltouniSimon AkarKazuyoshi AkibaPietro AlbicoccoJohannes AlbrechtFederico AlessioMichael AlexanderZakariya AliouchePaula Alvarez CartelleRenaud AmalricSandra AmatoJake Lewis AmeyYasmine AmhisLiupan AnLucio AnderliniMartin AnderssonAleksei AndreianovPasquale AndreolaMirco AndreottiDimitra AndreouAlessia AnelliDong AoFlavio ArchilliMatteo ArgentonSergio Arguedas CuendisAlexander ArtamonovMarina ArtusoElie AslanidesMichele AtzeniBenjamin AudurierDavid BacherIrene Bachiller PereaSebastian BachmannMarie BachmayerJohn BackPablo Baladron RodriguezVladislav BalaguraWander BaldiniHaoran BaoJuan Baptista de Souza LeiteMatteo BarbettiIvanildo Rui BarbosaRoger BarlowMikhail BarnyakovSergey BarsukWilliam BarterMatteo BartoliniJustin BartzFedor BaryshnikovJan-Marc BaselsGiovanni BassiBaasansuren BatsukhAlexander BattigAurelio BayAnja BeckMaik BeckerFranco BedeschiIgnacio BediagaSamuel BelinViolaine BelleeKonstantin BelousIlia BelovIvan BelyaevGaya BenaneGiovanni BencivenniEli Ben-HaimAlexander BerezhnoyRoland BernetSergi Bernet AndresAlessandro BertolinChristopher BetancourtFederico BettiJosh BexIaroslava BezshyikoJihyun BhomMartin Stefan BiekerNicolo Vladi BiesuzPierre BilloirAlice BiolchiniMatthew BirchFionn Caitlin Ros BishopAlexander BitadzeAndrea BizzetiThomas BlakeFrederic BlancJonah Evan BlankSteven BluskVladimir BocharnikovJulian Alexander BoelhauveOscar Boente GarciaThomas BoettcherAbhishek BohareAlexey BoldyrevCarolina BolognaniRiccardo BolzonellaNikolay BondarFederica BorgatoSilvia BorghiMartino BorsatoJozef Tomasz BorsukSonia Amina BouchibaThemistocles BowcockAlexandre BoyerConcezio BozziMatthew John BradleyAlexandre Brea RodriguezNils BreerJolanta BrodzickaArnau Brossa GonzaloJames David BrownDavide BrunduEmma BuchananAnnarita BuonauraLaura BuonincontriAodhan Tomas BurkeChristopher BurrAnatoly ButkevichJordy Sebastiaan ButterJan BuytaertWiktor ByczynskiSandro CadedduHao CaiRoberto CalabreseSaul Calderon RamirezLukas CaleficeStefano CaliMarta CalviMiriam Calvo GomezPatricia Camargo MagalhaesJose Ivan Cambon BouzasPierluigi CampanaDaniel Hugo Campora PerezAngel Fernando Campoverde QuezadaSimone CapelliLorenzo CapriottiRonald Gerardo Caravaca-MoraAngelo CarboneLidia Carcedo SalgadoRoberta CardinaleAlessandro CardiniPaolo CarnitiLeon David CarusAdrian Casais VidalRowina CasparyGianluigi CasseJorge Castro GodinezMarco CattaneoGiovanni CavalleroViola CavalliniSara CelaniDaniel CervenkovSara CesareAbbie Jane ChadwickIbrahim ChahrourMatthew CharlesPhilippe CharpentierCarlos Alberto Chavez BarajasMaximilien ChefdevilleChen ChenShanzhen ChenZewen ChenAleksei ChernovSerhii ChernyshenkoVeronika ChobanovaSerhii CholakMarcin ChrzaszczAleksei ChubykinVladimir ChulikovPaolo CiambroneXabier Cid VidalGregory CiezarekPierfrancesco CifraPeter ClarkeMarco ClemencicHarry CliffJoel ClosierCarlos Eduardo Cocha ToapaxiVictor CocoJulien CoganEric CognerasLucian CojocariuPaula CollinsTommaso ColomboAlbert Comerma-MontellsLiliana CongedoAndrea ContuNaomi CookeImanol CorredoiraAnthony CorreiaGloria CortiJosephine Jane Cottee MeldrumBenjamin CouturierDaniel Charles CraikMelissa Maria Cruz TorresEsteban Curras RiveraRobert CurrieCesar Luiz da SilvaShakhzod DadabaevLingyun DaiXinchen DaiElena Dall'OccoJeremy DalsenoCarmelo d'AmbrosioJessy DanielAnna DanilinaPhilippe d'ArgentAlexander DavidsonJonathan Edward DaviesAdam DavisOscar de Aguiar FranciscoCamilla de AngelisFederico de BenedettiJan de BoerKristof de BruynStefano de CapuaMichel de CianUlisses de Freitas Carneiro da GracaErika de LuciaJussara de MirandaLeandro de PaulaMarilisa de SerioPatrizia de SimoneFabio de VellisJacco de VriesFrancesco DebernardisDaniel DecampVlad-George DeduLuigi del BuonoBlaise DelaneyHans Peter DembinskiJianqiao DengVadym DenysenkoOlivier DeschampsFrancesco DettoriBiplab DeyPasquale Di NezzaIgor DiachkovSergey DidenkoShuchong DingLucas DittmannVasyl DobishukAleksandrina DochevaChenzhi DongAmanda May DonohoeFrancesca DordeiAlberto dos ReisAndrew Jay DowlingWeisong DuanPiotr Jakub DudaMaciej Wojciech DudekLaurent DufourViacheslav DukPaolo DuranteMaciej DurasJohn Matthew DurhamOzgur DurmusAgnieszka DziurdaAlexey DzyubaSajan EasoEllinor EcksteinUlrik EgedeArtem EgorychevVictor EgorychevStephan EisenhardtEnoch EjopuSurapat Ek-InLars EklundMohamed ElashriJan Hendrik EllbrachtScott ElyAlexandru EneEliane EppleJonas Nathanael EschleSevda EsenTimothy EvansFederica FabianoLucas FalcaoYanting FanBo FangLisa FantiniMaria FariaKeira Gwyn FarmerDavide FazziniLukasz Jerzy FelkowskiMingjie FengMauricio FeoMiguel Fernandez GomezAlex Daniel FernezFabio FerrariFernando Ferreira RodriguesSilvia Ferreres SoleMartina FerrilloMassimiliano Ferro-LuzziSergey FilippovRosa Anna FiniMassimiliano FioriniKamil Leszek FischerDillon Scott FitzgeraldConor FitzpatrickFrederic FleuretMarianna FontanaLucas Arthur ForemanRoger FortyDaniel Foulds-HoltManuel Franco SevillaMarkus FrankEdoardo FranzosoGiulia FrauChristoph FreiDavid Anthony FridayJinlin FuQuentin FuehringYuki FujiiTommaso FulghesuEmmy GabrielGiuliana GalatiMaria Domenica GalatiAbraham Gallas TorreiraDomenico GalliSilvia GambettaMiriam GandelmanPaolo GandiniBilal Ahmad GanieHan GaoRui GaoYang GaoYuanning GaoYuxi GaoMichela GarauLuis Miguel Garcia MartinPaula Garcia MorenoJulián García PardiñasKunal GargLluis GarridoClara GasparRobbert Erik GeertsemaLouis Lenard GerkenEvelina GersabeckMarco GersabeckTimothy GershonZahra GhorbanimoghaddamLuca GiambastianiFotis Ioannis GiasemisValerie GibsonHenryk Karol GiemzaAlexander Leon GilmanMatteo GiovannettiAlessandra GioventùPere Gironella GironellCarmen GiuglianoMaciej Artur GizaEvangelos Leonidas GkougkousisFabian Christoph GlaserVladimir GligorovCarla GöbelElisabet GolobardesDmitry GolubkovAndrey GolutvinAlvaro GomesSergio Gomez FernandezFernanda Goncalves AbrantesMateusz GoncerzGuanghua GongJames Andrew GoodingIgor Vladimirovich GorelovClaudio GottiJascha Peter GrabowskiLuis Alberto Granado CardosoEugeni GraugésElena GraveriniLuke GrazetteGiacomo GrazianiAlexandru Tudor GrecuLex Marinus GreevenNathan Allen GrieserLucia GrilloSergey GromovChenxi GuMarco GuariseManuel GuittiereVasilisa GuliaevaPaul Andre GüntherAbdul-Kerim GuseinovEvgeny GushchinYury GuzThierry GysKai Sebastian HabermannThomas HadavizadehChristos HadjivasiliouGuido HaefeliChristophe HaenJakob HaimbergerMohammadtaghi HajheidariMarius Maehlum HalvorsenPhoebe Meredith HamiltonJan HammerichQundong HanXiaoxue HanStephanie Hansmann-MenzemerLei HaoNeville HarnewMarie HartmannJibo HeFrederic HemmerConor HendersonRiley Dylan Leslie HendersonArthur Marius HennequinKarol HennessyLouis HenryJames Daniel HerdPaula Herrero GasconJohannes HeuelAdlène HicheurGuillermo Hijano MendizabalDonal HillSophie HollittJoshua Ethan HorswillRuiwen HouYingrui HouNed Francis HowarthJiangqiao HuJifeng HuWenhua HuXiaofan HuWenqian HuangWouter HulsbergenRoss John HunterMikhail HushchynDavid HutchcroftDmitrii IlinPhilip IltenAlexander InglessiAleksandr IniukhinArtur IshteevKuzma IvshinRichard JacobssonHendrik JageSergio Javier Jaimes EllesSune JakobsenEddy JansBrij Kishor JashalAbolhassan JawaheryVukan JevticEmily Kaiyin JiangXiaojie JiangYi JiangYuyang JiangMalcolm JohnDaniel JohnsonChristopher JonesThomas Peter JonesSalil JoshiBeat JostNathan JurikIzabela JuszczakDimitrios KaminarisSergii KandybeiYouen KangChandiprasad KarMatthias KaracsonDmitrii KarpenkovAnni KauniskangasJacob William KautzFloris KeizerMatthew KenzieTjeerd KetelBasem KhanjiAnastasiia KharisovaSergei KholodenkoGaelle KhreichThomas KirnVeronica Soelund KirsebomOuail KitouniSuzanne KlaverNico KleijneKonrad KlimaszewskiMateusz Rafal KmiecSerhii KoliievLars KolkAnatoly KonoplyannikovPawel KopciewiczPatrick KoppenburgMikhail KorolevIgor KostiukOleksander KotSofia KotriakhovaAnastasiia KozachukPolina KravchenkoLeonid KravchukMichal KrepsPavel KrokovnyWojciech KrupaWojciech KrzemienOleksandr KshyvanskyiJakub KubatSebastian Antoni KubisMarcin KucharczykVasily KudryavtsevEvgenia KulikovaAndrzej KupscBogdan KutsenkoDaniel LacarrereAdriano LaiAndrea LampisDavide LancieriniClara Landesa GomezJohn Jake LaneRichard LaneChristoph LangenbruchJan LangerOliver LantwinThomas LathamFederico LazzariCristina LazzeroniRenaud Le GacRegis LefèvreAlexander LeflatSergey LegotinMarion LehurauxEdgar Lemos CidOlivier LeroyTadeusz LesiakBlake LeveringtonAnfeng LiHengne LiKechen LiLanxing LiPeilian LiPei-Rong LiQinze LiShiyang LiTiange LiTianqi LiYanru LiYiming LiZhengchen LianXixin LiangSimone LibralonChuangxin LinTai-Hua LinRolf LindnerVitalii LisovskyiRoman LitvinovFrank Xiangyu LiuGuoming LiuKai LiuShuaiyi LiuYiming LiuYing LiuYiwei LiuAniol Lobo SalviaAngelo LoiJulian Lomba CastroThomas LongJose LopesAlbert Lopez HuertasSaúl López SoliñoChiara LucarelliDonatella LucchesiMiriam Lucio MartinezValeriia LukashenkoYiheng LuoAnna LupatoEleonora LuppiKate LynchXiao-Rui LyuGe MaRuiting MaSerena MaccoliniFrederic MachefertFlorin MaciucBridget MackInnes MackayLauren Grace MackeyLakshan Ram Madhan MohanMarcus Jonathan MaduraiArtem MaevskiyDaniel MagdalinskiDmitrii MaisuzenkoMaciej Witold MajewskiJakub Jacek MalczewskiSneha MaldeLorenzo MalentaccaAlexander MalininTimofei MaltsevGiulia MancaGiampiero MancinelliChiara MancusoRafel Manera EscaleroDaniele ManuzziDaniele MarangottoJean François MarchandRadoslav MarchevskiUmberto MarconiSaverio MarianiCarla Marin BenitoJörg MarksAlexander Mclean MarshallGabriele MartelliGiuseppe MartellottiLoris MartinazzoliMaurizio MartinelliDiego Martinez SantosFernando Martinez VidalAndré MassafferriRosen MatevAbhijit MathadViacheslav MatiuninClara MatteuzziKara Renee MattioliAndrea MauriEmilie MauriceJoan MauricioPierre Paul Louis MayencourtMichal MazurekMichael MccannLucas McconnellTamaki Holly McgrathNiall Thomas MchughAndrew McnabRonan McnultyBrian MeadowsGerwin MeierDmytro MelnychukFanjie MengMarcel MerkAndrea MerliLucas Meyer GarciaDexing MiaoHan MiaoMikhail MikhasenkoDiego Alejandro MilanesAlessandro MinottiElisa MinucciTristan MirallesBiljana MitreskaDominik Stefan MitzelAtanu ModakAntje MöddenRizwaan Adeeb MohammedRazvan-Daniel MoiseSergei MokhnenkoTitus MombächerMatthew David MonkStephane MonteilAngel Morcillo GomezGianfranco MorelloMichael Joseph MorelloMaurice Pierre MorgenthalerAdam Benjamin MorrisAndrew George MorrisRaymond MountainHongjie MuZeqing MuEmir MuhammadFranz MuheimMick MulderKatharina MüllerFederico Muñoz-RojasRebecca MurtaParas NaikTatsuya NakadaRaja NandakumarTara NanutIrina NastevaMatthew NeedhamNicola NeriSebastian NeubertNiko NeufeldPetr NeustroevJanina NicoliniDavide NicotraElisabeth Maria NielNikolay NikitinPiet NoggaNiklas Stefan NolteCamille NormandJulio Novoa FernandezGabriel Matthew NowakCynthia NunezHavva Hasret NurAgnieszka Oblakowska-MuchaVladimir ObraztsovThomas OeserShinichi OkamuraArtem OkhotnikovOleksandr OkhrimenkoRudolf OldemanFederica OlivaMicol OloccoGerco OnderwaterRyunosuke Hugo O'NeilJuan Martin Otalora GoicocheaPatrick OwenMaria Aranzazu OyangurenOzlem OzcelikKlaas Ole PadekenBhagyashree PagarePreema Rennee PaisTommaso PajeroAntimo PalanoMatteo PalutanGennady PanshinLorenzo PaolucciAntonios PapanestisMarco PappagalloLuciano PappalardoCheryl PappenheimerChristopher ParkesBarbara PassalacquaGiovanni PassalevaDaniele PassaroAlessandra PastoreMitesh PatelJairus Tristan PatocClaudia PatrignaniAntara PaulChristopher James PawleyAntonio PellegrinoJi PengMonica Pepe AltarelliStefano PerazziniDmitrii PereimaAsier Pereiro CastroPascal PerretAlberto PerroKonstantinos PetridisAlessandro PetroliniJacob PfallerHang PhamLorenzo PicaMauro PicciniBoleslaw PietrzykGuillaume PietrzykDavide PinciFlavio PisaniMarco PizzichemiVlad-Mihai PlacintaMaximo Plo CasasusFrancesco PolciMarco Poli LenerAnton PoluektovNatalia PolukhinaIvan PolyakovErica PolycarpoSebastien PonceDmitry PopovStanislav PoslavskiiKodassery PrasanthClaire ProuveValery PugatchGiovanni PunziShah Rukh QasimWenbin QianNing QinSanqiang QuRenato QuaglianiBoris QuintanaRaul Iraq Rabadan TrejoJonas RademackerMatteo RamaManuel Ramírez GarcíaMiguel Ramos PernasMurilo RangelFedor RatnikovGerhard RavenMiguel Rebollo de MiguelFederico RediJake ReichFlorian ReissZan RenP.K ResmiRoberto RibattiGabriel RicartDomenico RiccardiStefania RicciardiKate Abigail RichardsonMary Richardson-SlipperKurt RinnertPatrick RobbeGary RobertsonEduardo RodriguesEmilio Xose Rodriguez FernandezJairo Alexis Rodriguez LopezEfren Rodriguez RodriguezAlexander RogovskiyDavid Leonhard RolfPhilipp RoloffVladimir RomanovskiyMarcos Romero LamasAntonio Romero VidalGabriele RomoliniFederico RonchettiMarcello RotondoShreya RoyMatthew Scott RudolphThomas RufMiguel Ruiz DiazRamon Angel Ruiz FernandezJoan Ruiz VidalArtem RyzhikovJakub RyzkaJose Javier Saavedra-AriasJuan Jose Saborido SilvaRita SadekNaylya SagidovaDebashis SahooNiladribihari SahooBiagio SaittaMatteo SalomoniCristina Sanchez GrasIzaac SanderswoodRoberta SantacesariaCibran Santamarina RiosMarco SantimariaLeonardo SantoroEmanuele SantovettiAlessandro SaputiDanila SaraninGediminas SarpisMindaugas SarpisCelestina SatrianoAlessia SattaMiroslav SaurDarya SavrinaHalime SazakLuke George Scantlebury SmeadAlessandro ScarabottoStefan SchaelSigrid ScherlManuel SchillerHeinrich SchindlerMichael SchmellingBurkhard SchmidtSebastian SchmittHannah SchmitzOlivier SchneiderAndreas SchopperNicole SchulteSebastian SchulteMarie Helene SchuneRainer SchwemmerGeorg SchweringBarbara SciasciaAugusto SciuccatiSara SellamAlexander SemennikovThomas Christian SengerMara Senghi SoaresAntonino SergiNicola SerraLorenzo SestiniAlex SeutheYiduo ShangDesmond Mzamo ShangaseMikhail ShapkinRashi SharmaIvan ShchemerovLesya ShchutskaTara ShearsLev ShekhtmanZhihong ShenShuqi ShengVladimir ShevchenkoBoan ShiQi ShiEdward Brendan ShieldsYuya ShimizuEvgenii ShmaninRoman ShorkinJoseph David ShupperdRafael Silva CoutinhoGabriele SimiSaverio SimoneNicola SkidmoreTomasz SkwarnickiMark SlaterJennifer Clare SmallwoodEluned SmithKrista Lizbeth SmithMark SmithAleksandra SnochLais Soares LavraMichael SokoloffPaul SolerAnatoly SolominAleksandr SolovevIvan SolovyevRongrong SongYunxuan SongYuxiang SongYintong SongFelipe Luan Souza de AlmeidaBruno Souza de PaulaElisabetta Spadaro NorellaEugenia SpedicatoJannis Guido SpeerEduard SpiridenkovPatrick SpradlinViros SriskaranFederico StagniMarian StahlSascha StahlSeophine StanislausEloise Noelle SteinOlaf SteinkampOleg StenyakinHolger StevensDaria StrekalinaYangjie SuFidan SuljikJiayin SunLiang SunYipeng SunDaniel Sundfeld LimaWilliam SutcliffePaul Nathaniel SwallowFrancesca SwystunAdam SzabelskiTomasz SzumlakYinghua TanMartin Duy TatAleksandr TerentevFrancesco TerzuoliFrederic TeubertEric ThomasDaniel James David ThompsonHanae TilquinVincent TisserandStephane t'JampensMark TobinLuca TomassettiGiorgia TonaniXingyu TongDiego Torres MachadoLuca Toscanoda Yu TouCarina TripplGiulia TuciNiels TuningLennart Henning UeckerArtur UklejaDaniel Joachim UnverzagtEduard UrsovAndrii UsachovAndrey UstyuzhaninUlrich UwerVincenzo VagnoniAndrea ValassiGiovanni ValentiNuria Valls CanudasHubert van HeckeEric van HerwijnenCharlotte Barbara van HulseRaphael van LaakMaarten van VeghelGerardo VasquezRicardo Vazquez GomezPablo Vazquez RegueiroCarlos Vázquez SierraStefania VecchiJaap VelthuisMichele VeltriAravindhan VenkateswaranMika VesterinenMaria Vieites DiazXavier Vilasis-CardonaEva Vilella FiguerasAndrea VillaPascal VincentFelicia Carolin VolleDorothea Vom BruchNikolai VoropaevKimberley VosGuillaume VoutersConstantinos VrahasJan Peter WagnerJohn WalshEliot Jane WaltonGuanyue WanChishuai WangGanrong WangJialu WangJianchun WangJianqiao WangJike WangMengzhen WangNanyang WangRui WangXiao WangXiaolin WangXiaohan WangZhenzi WangZirui WangZiyi WangJake Alexander WardMark WaterlaatNigel WatsonDavid WebsdaleYajing WeiJohn WendelBenedict Donald C WesthenryDylan Jaide WhiteMark WhiteheadAidan Richard WiederholdDirk WiednerGuy WilkinsonMichael K WilkinsonMike WilliamsMark Richard James WilliamsRichard Morgan WilliamsFergus WilsonWojciech WislickiMariusz WitekLukas WitolaCheuk Ping WongGuy WormserStephen WottonHangyi WuJie WuYanxi WuKenneth WyllieShu XianZhiyu XiangYuehong XieAo XuJingyi XuLi XuLiangjun XuMenglin XuZehua XuZhihao XuZijun XuDi YangShuangli YangXueting YangYouhua YangZhenwei YangZishuo YangVsevolod YeroshenkoHo Yin Dereck YeungHang YinChenxu YuJiesheng YuXuhao YuanEttore ZaffaroniMikhail ZavertyaevMilosz ZdybalMing ZengChenjia ZhangDongliang ZhangJianyu ZhangLiming ZhangShulei ZhangShunan ZhangYanxi ZhangYuge ZhangYa ZhaoAlina ZharkovaAlexey ZhelezovXutao ZhengYangheng ZhengTianwen ZhouXiaokang ZhouYixiong ZhouValeriia ZhovkovskaLinxuan ZhuXianglei ZhuXiaoyu ZhuValery ZhukovJiahui ZhuoQuan ZouDavide ZulianiGianluca Zunica
• Organismes : Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Laboratoire d'Annecy de Physique des Particules Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire Leprince-Ringuet Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire Leprince-Ringuet Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
• Publié dans JHEP le 14/01/2026

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Résumé : A search for radiative decay of $B^0_s$ mesons to orbitally excited $K^+K^-$ states is performed using proton proton collisions recorded by the \mbox{LHCb}\xspace experiment, corresponding to an integrated luminosity of 9~fb$^{-1}$. The dikaon spectrum in the mass range $m_{KK}<2400$~{\ensuremath{\,\text{Me\kern -0.1em V\!/}c^2}\xspace} is dominated by the $\phi(1020)$ resonance that accounts for almost 70$\%$ of the decay rate. Considering the possible contributions of $f_2{(1270)}$, $f'_2{(1525)}$ and $f_2{(2010)}$ meson states, the overall tensor contribution to the amplitude is measured to be \begin{equation} {\cal F}_{\{f_2\}}=16.8\pm 0.5\mathrm{~(stat.)}\pm0.7\mathrm{~(syst.)}\%,\nonumber \end{equation} mostly dominated by the $f'_2(1525)$ state. Several statistically equivalent solutions are obtained for the detailed resonant structure depending on whether the smaller amplitudes interfere destructively or constructively with the dominant amplitude. The preferred solution that corresponds to the lowest values of the fit fractions along with constructive interference leads to the relative branching ratio measurement \begin{equation} \frac{{\cal B}(B^0_s\to f'_2\gamma)}{{\cal B}(B^0_s\to\phi\gamma)}= 19.4^{+0.9}_{-0.8}\mathrm{~(stat.)}{}^{+1.4}_{-0.5}\mathrm{~(syst.)}\pm0.5\mathrm{~(\cal{B})}\%\nonumber, \end{equation} where the last uncertainty is due to the ratio of measured branching fractions to the $K^+K^-$ final state. This result represents the first observation of the radiative $B^0_s\to f'_2(1525)\gamma$ decay, which is the second radiative transition observed in the $B^0_s$ sector.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Pierre BigotRomain BoissierZine Eddine KheneLaurence AlbigèsJean Christophe BernhardJean Michel CorreasStéphane de VergieNicolas DoumercMatthieu FerraguAlexandre IngelsGaëlle MargueIdir OuzaïdCaroline PettenatiNathalie Rioux-LeclercqPaul SargosThibaut WaeckelPhilippe BarthelemyMorgan Rouprêt
• Organismes : Centre Hospitalier Universitaire d'Angers Aix Marseille Université Assistance Publique - Hôpitaux de Marseille Centre Hospitalier Universitaire d'Angers Hôpital Sud [CHU Rennes] Institut Gustave Roussy Université Paris-Saclay Département de médecine oncologique [Gustave Roussy] Centre Hospitalier Universitaire de Bordeaux Université Paris Cité Assistance publique - Hôpitaux de Paris (AP-HP) Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire d'Angers Hôpital Henri Mondor Centre Hospitalier Universitaire de Bordeaux Assistance publique - Hôpitaux de Paris (AP-HP) Hôpital Henri Mondor Hôpital Foch [Suresnes] UFR Sciences de la santé Simone Veil Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail Centre Hospitalier Universitaire de Bordeaux CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Institut de Cancérologie de Strasbourg Europe CHU Pitié-Salpêtrière [AP-HP] Assistance publique - Hôpitaux de Paris (AP-HP) Sorbonne Université
• Publié dans The French Journal of Urology le 29/03/2024

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Résumé : Objective: To update the French recommendations for the management of kidney cancer. Methods: A systematic review of the literature was conducted for the period from 2014 to 2024. The most relevant articles concerning the diagnosis, classification, surgical treatment, medical treatment, and follow-up of kidney cancer were selected and incorporated into the recommendations. The recommendations have been updated specifying the level of evidence (strong or weak). Results: Kidney cancer following prolonged occupational exposure to trichloroethylene should be considered an occupational disease. The reference examination for the diagnosis and staging of kidney cancer is the contrast-enhanced thoraco-abdominal CT scan. PET scans are not indicated in the staging of kidney cancer. Percutaneous biopsy is recommended in situations where its results will influence therapeutic decisions. It should be used to reduce the number of surgeries for benign tumors, particularly avoiding unnecessary radical nephrectomies. Kidney tumors should be classified according to the pTNM 2017 classification, the WHO 2022 classification, and the ISUP nucleolar grade. Metastatic kidney cancers should be classified according to IMDC criteria. Surveillance of tumors smaller than 2 cm should be prioritized and can be offered regardless of patient age. Robot-assisted laparoscopic partial nephrectomy is the reference surgical treatment for T1 tumors. Ablative therapies and surveillance are options for elderly patients with comorbidities for tumors larger than 2 cm. Stereotactic radiotherapy is an option to discuss for treating localized kidney tumors in patients not eligible for other treatments. Radical nephrectomy is the first-line treatment for locally advanced localized cancers. Pembrolizumab is recommended for patients at high risk of recurrence after surgery for localized kidney cancer. In metastatic patients, cytoreductive nephrectomy can be immediate in cases of good prognosis, delayed in cases of intermediate or poor prognosis for patients stabilized by medical treatment, or as u201cconsolidationu201d in patients with complete or major partial response at metastatic sites after systemic treatment. Surgical or local treatment of metastases can be proposed for single lesions or oligometastases. Recommended first-line drugs for metastatic clear cell renal carcinoma are combinations of axitinib/pembrolizumab, nivolumab/ipilimumab, nivolumab/cabozantinib, and lenvatinib/pembrolizumab. Patients with non-clear cell metastatic kidney cancer should be presented to the CARARE Network and prioritized for inclusion in clinical trials. Conclusion: These updated recommendations are a reference that will enable French and French-speaking practitioners to optimize their management of kidney cancer.

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Fichiers liés : 1-s2.0-S295039302400192X-main.pdf

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