Clinical Presentation and Outcomes of Patients With Cancer-Associated Isolated Distal Deep Vein Thrombosis
- Type de publi. : Article dans une revue
- Date de publi. : 20/07/2023
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Auteurs :
Jean-Philippe GalanaudJavier Trujillo-SantosBehnood BikdeliLaurent BertolettiPierpaolo Di MiccoGéraldine PoenouConxita FalgáMarija ZdraveskaJorge LimaFrancisco Rivera-CivicoJosefa Fernández MuixiManuel MonrealMaría Dolores AdarragaAna Alberich-ConesaPaloma AgudoJesús AibarJoaquín AlfonsoCristina AmadoSoraia AmorósMaría Angelina-GarcíaJuan Ignacio ArcelusAitor BallazRaquel BarbaCristina BarbagelataManuel BarrónBelén Barrón-AndrésJosé BascuñanaFahd Beddar-ChaibÁngeles Blanco-MolinaErnesto BotellaLeyre ChascoPau CerdàJuan CriadoJorge Del ToroCristina de AncosPablo Demelo-RodríguezCristina de Juana-IzquierdoAna María Díaz-BraseroMaría del Carmen Díaz-PedrocheJosé Antonio Díaz-PeromingoÁlvaro Dubois-SilvaJosé Carlos EscribanoFrancis EspósitoConxita FalgáAna Isabel Farfán-SedanoCloefe Fernández-AracilCarmen Fernández-CapitánBegoña Fernández-JiménezJosefa Fernández-MuixiJosé Luis Fernández-ReyesCarme FontIria FranciscoCristina GabaraMarta García de HerrerosFerrán García-BragadoAlberto García-OrtegaOlga Gavín-SebastiánMaría Gil-de GómezAída Gil-DíazCovadonga Gómez-CuervoJosé González-MartínezEnric GrauLeticia GuiradoJavier GutiérrezLuis Hernández-BlascoMaría Jesús JarasDavid JiménezInés JouMaría Dolores JoyaMarta Olimpia Lago-RodríguezSara Lainez-JustoAna Latorre-DíezRamón LecumberriJosé Manuel León-RamírezJorge LimaJosé Luis LoboMeritxell López-de la FuenteLuciano López-JiménezPatricia López-MiguelJuan José López-NúñezRaquel López-ReyesAntonio López-RuizJuan Bosco López-SáezManuel Alejandro LorenteAlicia LorenzoMarina LumbierresOlga MadridanoAna MaestreLaia Mas-MaresmaMaría MarcosJavier Miguel Martín-GuerraFrancisco Martín-MartosIván Martínez-RedondoMeritxell MelladoElisabeth MenaMaría Isabel MercadoJorge MoisésManuel MonrealArturo Muñoz-BlancoGema Muñoz-GamitoMaría Sierra NavasJosé Antonio NietoElisabeth Noguera-GrasManuel Jesús Núñez-FernándezMónica Olid-VelillaLucia Ordieres-OrtegaMaría OrtizJeisson OsorioSonia OtáloraNazaret Pacheco-GómezDiana Paredes-RuizPedro ParraJosé María PedrajasCristina Pérez-DuctorMaría Luisa PerisMaría Lourdes PesceJosé Antonio PorrasJavier Poyo-MolinaRamón PuchadesAntoni Riera-MestreFrancisco Rivera-CivicoAlberto Rivera-GallegoMireia RocaVladimir RosaAna Rodríguez-CoboConsolación Rodríguez-MatuteCarmen María RubioPedro Ruiz-ArtachoNuria Ruiz-GiménezJusto Ruiz-RuizGiorgina SalgueiroTeresa SanchoVanesa SendínPatricia SigüenzaSilvia SolerBeatriz Suárez-RodríguezJosé María SuriñachRaimundo TiradoCarles TolosaMaría Isabel TorresJavier Trujillo-SantosFernando UresandiReina ValleJosé Felipe VaronaGema VidalPaula VillaresCihan AyStephan NoppIngrid PabingerCaroline MartensThomas VanasschePeter VerhammeHugo Hyung Bok YooJesús David ArguelloAna Cristina MontenegroJairo RoaJana HirmerovaRadovan MalýSandrine AccassatLaurent BertolettiAlessandra Bura-RiviereJudith Catella-ChatronRomain ChopardFrancis CouturaudOliver EspitiaClaire GrangeBarbara LeclercqRaphael Le MaoIsabelle MahéFarés MoustafaLudovic PlaisanceGéraldine PoenouGabrielle Sarlon-BartoliPierre SuchonEdouard VersiniSebastian SchellongBenjamin BrennerNajib DallyInna TzoranRaheleh KavianiJamal MoosaviParham SadeghipourManuela BasagliaFranca BiloraCristiano BortoluzziBarbara BrandolinMauricio CiammaichellaDonatella ColaizzoFrancesco Dentali FPierpaolo Di MiccoMatteo Giorgi-PierfranceschiElvira GrandoneEgidio ImbalzanoSimona MerlaRaffaele PesaventoPaolo PrandoniPaolo ScarinziCarmine SiniscalchiBeldisa TaflajAntonella TufanoAdriana VisonàNgoc Vo HongBeniamino ZalunardoDana KigitovicaRolands PalugaAndris SkrideSamuel FonsecaMicaela ManuelJose MeirelesSara PintoMarijan BosevskiEmilija LazarovaMarija ZdraveskaHenri BounameauxLucia MazzolaiJoseph CapriniIdo WeinbergHanh My Bui
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Organismes :
Department of Medicine, Sunnybrook Heath Sciences Centre, University of Toronto, Toronto, ON, Canada
Service de Médecine Vasculaire et Thérapeutique
U 1059 – SAINBIOSE Bio-ingénierie
Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]
- Publié dans Journal of Clinical Oncology le 01/11/2020
Résumé : PURPOSE Patients with isolated distal deep vein thrombosis (DVT) have lower rates of adverse outcomes (death, venous thromboembolism [VTE] recurrence or major bleeding) than those with proximal DVT. It is uncertain if such findings are also observed in patients with cancer. METHODS Using data from the international Registro Informatizado de la Enfermedad TromboEmbolica venosa registry, we compared the risks of adverse outcomes at 90 days (adjusted odds ratio [aOR]; 95% CI) and 1 year (adjusted hazard ratio [aHR; 95% CI]) in 886 patients with cancer-associated distal DVT versus 5,196 patients with cancer-associated proximal DVT and 5,974 patients with non–cancer-associated distal DVT. RESULTS More than 90% of patients in each group were treated with anticoagulants for at least 90 days. At 90 days, the adjusted risks of death, VTE recurrence, or major bleeding were lower in patients with non–cancer-associated distal DVT than in patients with cancer-associated distal DVT (reference): aOR = 0.16 (0.11-0.22), aOR = 0.34 (0.22-0.54), and aOR = 0.47 (0.27-0.80), respectively. The results were similar at 1-year follow-up: aHR = 0.12 (0.09-0.15), aHR = 0.39 (0.28-0.55), and aHR = 0.51 (0.32-0.82), respectively. Risks of death, VTE recurrence, and major bleeding were not statistically different between patients with cancer-associated proximal versus distal DVT, both at 90 days: aOR = 1.11 (0.91-1.36), aOR = 1.10 (0.76-1.62), and aOR = 1.18 (0.76-1.83), respectively, and 1 year: aHR = 1.01 (0.89-1.15), aHR = 1.02 (0.76-1.35), and aHR = 1.10 (0.76-1.61), respectively. However, more patients with cancer-associated proximal DVT, compared with cancer-associated distal DVT, developed fatal pulmonary embolism (PE) during follow-up: The risk difference was 0.40% (95% CI, 0.23 to 0.58). CONCLUSION Cancer-associated distal DVT has serious and relatively comparable outcomes compared with cancer-associated proximal DVT. The lower risk of fatal PE from cancer-associated distal DVT needs further investigation.
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