Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Yuanwei QinXiangming XiaoWigneron J.-P.Philippe CiaisMartin BrandtSassan S SaatchiXiaojun LiSean CrowellXiaocui WuRussell DoughtyYao ZhangFang LiuStephen SitchBerrien Moore
• Organismes : University of Oklahoma University of Oklahoma Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC University of Copenhagen = Københavns Universitet Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère University of Oklahoma University of Oklahoma University of Oklahoma Lawrence Berkeley National Laboratory [Berkeley] Chinese Academy of Sciences [Beijing] University of Exeter University of Oklahoma
• Publié dans Nature Climate Change le 30/10/2020

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Résumé : Spatial–temporal dynamics of aboveground biomass (AGB) and forest area affect the carbon cycle, climate and biodiversity in the Brazilian Amazon. Here we investigate interannual changes in AGB and forest area by analysing satellite-based annual AGB and forest area datasets. We found that the gross forest area loss was larger in 2019 than in 2015, possibly due to recent loosening of forest protection policies. However, the net AGB loss was three times smaller in 2019 than in 2015. During 2010–2019, the Brazilian Amazon had a cumulative gross loss of 4.45 Pg C against a gross gain of 3.78 Pg C, resulting in a net AGB loss of 0.67 Pg C. Forest degradation (73%) contributed three times more to the gross AGB loss than deforestation (27%), given that the areal extent of degradation exceeds that of deforestation. This indicates that forest degradation has become the largest process driving carbon loss and should become a higher policy priority.

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Fichiers liés : s41558-021-01026-5.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Ronan RousselPatrice DarmonMatthieu PichelinThomas GoronflotYawa AboulekaLeila Ait BachirIngrid AllixDeborah AncelleSara BarraudLyse BordierAurélie CarlierNicolas ChevalierChristine Coffin‐boutreuxEmmanuel CossonAnne DorangeOlivier DupuyPierre FontaineBénédicte FremyFlorence GaltierNatacha GermainAnne‐marie GuedjEtienne LargerStéphanie Laugier‐robiolleBruno LaviolleLisa LudwigArnaud MonierNathanaëlle MontanierPhilippe MoulinIsabelle MouraGaëtan PrevostYves ReznikNadia SabbahPierre-Jean SaulnierPierre SerusclatCamille VatierMatthieu WargnySamy HadjadjPierre GourdyBertrand Cariou
• Organismes : Centre de Recherche des Cordeliers Service d'endocrinologie, diabétologie et nutrition [CHU Bichat] Aix Marseille Université Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research ITX - unité de recherche de l'institut du thorax Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes Centre de Recherche des Cordeliers Service d'endocrinologie, diabétologie et nutrition [CHU Bichat] CHU d'Angers [Département Urgences] Centre Hospitalier Universitaire d'Angers Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 Hôpital d'Instruction des Armées Begin [Saint-Mandé, France] Centre de Recherche des Cordeliers Service d'endocrinologie, diabétologie et nutrition [CHU Bichat] Centre méditerranéen de médecine moléculaire Unité de Recherche en Epidémiologie Nutritionnelle Centre Hospitalier Le Mans (CH Le Mans) Centre hospitalier Saint-Joseph [Paris] Hôpital Claude Huriez [Lille] CIC Montpellier Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire de Nîmes Service de diabétologie [CHU Cochin] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Nancy Hôpitaux de Chartres [Chartres] Cardiovasculaire, métabolisme, diabétologie et nutrition Service d'endocrinologie, diabétologie et maladies métaboliques [Rouen] Différenciation et communication neuronale et neuroendocrine Service Endocrinologie - Diabétologie [CHU Caen] Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre de Recherche Saint-Antoine ITX - unité de recherche de l'institut du thorax Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX - unité de recherche de l'institut du thorax Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Institut des Maladies Métaboliques et Cardiovasculaires ITX - unité de recherche de l'institut du thorax Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Diabetes, Obesity and Metabolism le 01/11/2020

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Résumé : Aim: To investigate the association between routine use of dipeptidyl peptidase-4 (DPP-4) inhibitors and the severity of coronavirus disease 2019 (COVID-19) infection in patient with type 2 diabetes in a large multicentric study. Materials and Methods: This study was a secondary analysis of the CORONADO study on 2449 patients with type 2 diabetes (T2D) hospitalized for COVID-19 in 68 French centres. The composite primary endpoint combined tracheal intubation for mechanical ventilation and death within 7 days of admission. Stabilized weights were computed for patients based on propensity score (DPP-4 inhibitors users vs. non-users) and were used in multivariable logistic regression models to estimate the average treatment effect in the treated as inverse probability of treatment weighting (IPTW). Results: Five hundred and ninety-six participants were under DPP-4 inhibitors before admission to hospital (24.3%). The primary outcome occurred at similar rates in users and non-users of DPP-4 inhibitors (27.7% vs. 28.6%; p = .68). In propensity analysis, the IPTW-adjusted models showed no significant association between the use of DPP-4 inhibitors and the primary outcome by Day 7 (OR [95% CI]: 0.95 [0.77-1.17]) or Day 28 (OR [95% CI]: 0.96 [0.78-1.17]). Similar neutral findings were found between use of DPP-4 inhibitors and the risk of tracheal intubation and death. Conclusions: These data support the safety of DPP-4 inhibitors for diabetes management during the COVID-19 pandemic and they should not be discontinued.

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Fichiers liés : Roussel et al-2021-Use of Dipeptidyl Peptidase-4 inhibitors and prognosis of COVID-19 in.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/04/2021
• Auteurs : Vincent BondetMathieu P RoderoCéline PossemePierre BostJérémie DecalfLiis HaljasmägiNassima BekaddourGillian I. RiceVinit UpasaniJean Philippe HerbeuvalJohn A. ReynoldsTracy A. BriggsIan N. BruceClaudia MauriDavid IsenbergMadhvi MenonDavid HuntBenno SchwikowskiXavier MarietteStanislas PolNathalie BoddaertTineke CantaertJ. Eric GottenbergKai KisandDarragh Duffy
• Organismes : Immunologie Translationnelle - Translational Immunology lab Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques Immunologie Translationnelle - Translational Immunology lab Université Paris Cité Biologie systémique - Systems Biology Ecole Doctorale Complexité du Vivant Immunobiologie des Cellules dendritiques Tartu University Hospital Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques University of Manchester [Manchester] Manchester University NHS Foundation Trust Immunologie [Phnom Penh] Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques University of Manchester [Manchester] University of Birmingham [Birmingham] Sandwell and West Birmingham Hospitals NHS Trust University of Manchester [Manchester] Manchester University NHS Foundation Trust University of Manchester [Manchester] University College London [UCL] University College London [UCL] University College London [UCL] University of Manchester [Manchester] The University of Edinburgh Biologie systémique - Systems Biology Ecole Doctorale Complexité du Vivant Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Service de Rhumatologie [CHU Bicêtre] Service d'hépatologie médicale [CHU Cochin] Service de Virologie [CHU Cochin] Université Paris Cité Immunologie [Phnom Penh] Université de Strasbourg Tartu University Hospital Immunologie Translationnelle - Translational Immunology lab
• Publié dans Cytokine le 31/10/2020

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Résumé : Type I interferons are essential for host response to viral infections, while dysregulation of their response can result in autoinflammation or autoimmunity. Among IFNα (alpha) responses, 13 subtypes exist that signal through the same receptor, but have been reported to have different effector functions. However, the lack of available tools for discriminating these closely related subtypes, in particular at the protein level, has restricted the study of their differential roles in disease. We developed a digital ELISA with specificity and high sensitivity for the IFNα2 subtype. Application of this assay, in parallel with our previously described pan-IFNα assay, allowed us to study different IFNα protein responses following cellular stimulation and in diverse patient cohorts. We observed different ratios of IFNα protein responses between viral infection and autoimmune patients. This analysis also revealed a small percentage of autoimmune patients with high IFNα2 protein measurements but low pan-IFNα measurements. Correlation with an ISG score and functional activity showed that in this small sub group of patients, IFNα2 protein measurements did not reflect its biological activity. This unusual phenotype was partly explained by the presence of anti-IFNα auto-antibodies in a subset of autoimmune patients. This study reports ultrasensitive assays for the study of IFNα proteins in patient samples and highlights the insights that can be obtained from the use of multiple phenotypic readouts in translational and clinical studies.

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Fichiers liés : 1-s2.0-S1043466621001137-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/04/2021
• Auteurs : Steven Le GouillHervé GhesquieresLucie ObéricFranck MorschhauserHervé TillyVincent RibragThierry LamyCatherine ThieblemontHerve Gerard MaisonneuveRemy GressinKrimo BouabdallahCorinne HaiounGandhi DamajLuc-Matthieu ForneckerReda BouabdallahPierre FeugierDavid SibonGuillaume CartronChristophe BonnetMarc AndréLoic ChartierPhilippe RuminyF Kraeber-BodereC Bodet-MilinAlina Berriolo-RiedingerJosette BriereJean-Philippe JaisThierry MolinaEmmanuel IttiOlivier Casasnovas
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Regulation of Bcl2 and p53 Networks in Multiple Myeloma and Mantle Cell Lymphoma Immuno-Biologie des Lymphomes [CIRI] Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL] Institut Universitaire du Cancer de Toulouse - Oncopole Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Institut Gustave Roussy Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse Microenvironment, Cell Differentiation, Immunology and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Service d'Hémato-oncologie [CHU Saint-Louis] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Hôpital Michallon CHU Pessac CHI Créteil Institut d'Hématologie de Basse-Normandie Hôpitaux Universitaires de Strasbourg Institut Paoli-Calmettes Centre Hospitalier Régional Universitaire de Nancy Nutrition-Génétique et Exposition aux Risques Environnementaux Hôpital Necker - Enfants Malades [AP-HP] Institut de Génétique Moléculaire de Montpellier Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Liège CHU UCL Namur The Lymphoma Academic Research Organisation [Lyon] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Hopital Saint-Louis [AP-HP] Université Paris Descartes - Paris 5 Hôpital Necker - Enfants Malades [AP-HP] CHI Créteil CHU Dijon
• Publié dans Blood le 28/10/2020

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Résumé : Rituximab plus polychemotherapy is the standard of care in diffuse large B-cell lymphoma (DLBCL). GAINED, a randomized phase 3 trial, compared obinutuzumab to rituximab. Transplant-eligible patients (18-60 years) with an untreated age-adjusted International Prognostic Index (aaIPI) score ≥1 DLBCL were randomized (1:1) between obinutuzumab or rituximab and stratified by aaIPI (1; 2-3) and chemotherapy regimen (doxorubicin, cyclophosphamide, prednisone plus vindesine, bleomycin [ACVBP] or vincristine [CHOP]). Consolidation treatment was determined according to response to interim positron emission tomography (PET). Responders after cycle 2 and 4 (PET2-/PET4-) received immunochemotherapy. Responders after only cycle 4 (PET2+/4-) received transplantation. The primary objective was an 8% improvement (hazard ratio [HR] = 0.73; 80% power; α risk, 2.5%; 1-sided) in 2-year event-free survival (EFS) in the obinutuzumab arm. From September 2012, 670 patients were enrolled (obinutuzumab, n = 336; rituximab, n = 334). A total of 383 (57.2%) were aaIPI 2-3, 339 (50.6%) received CHOP. Median follow-up was 38.7 months. The 2-year EFS was similar in both groups (59.8% vs 56.6%; P = .123; HR = 0.88). The 2-year PFS in the whole cohort was 83.1% (95% confidence interval, 80% to 85.8%). PET2-/4- and PET2+/4- had similar 2-year progression-free survival (PFS) and overall survival (OS): 89.9% vs 83.9% and 94.8% vs 92.8%. The 2-year PFS and OS for PET4+ patients were 62% and 83.1%. Grade 3-5 infections were more frequent in the obinutuzumab arm (21% vs 12%). Obinutuzumab is not superior to rituximab in aaIPI ≥1 DLBCL transplant-eligible patients. This trial was registered at www.clinicaltrials.gov as #NCT01659099.

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Fichiers liés : Le Gouill et al-2020-Obinutuzumab versus Rituximab in young patients with advanced DLBCL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/04/2021
• Auteurs : Romain PaccoudCéline Saint-LaurentEnzo PiccoloMylène TajanAlizée DortignacOphélie PereiraSophie Le-GonidecInès BabaAdélaïde GélineauHaoussa AskiaMaxime BranchereauJulie CharpentierJean PersonnazSophie BrankaJohanna AuriauSimon DeleruyelleMickaël CanouilNicolas BetonJean‐pierre SallesM. TauberJacques WeillPhillippe FroguelBenjamin NeelToshiyuki ArakiChristophe HeymesRémy BurcelinIsabelle Castan-LaurellPhilippe P. ValetCedric DrayEmmanuel GautierThomas EdouardJean-Philippe PradèreArmelle Yart
• Organismes : Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Geroscience and rejuvenation research center Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Centre de Physiopathologie Toulouse Purpan Centre Hospitalier Universitaire de Toulouse Centre de Physiopathologie Toulouse Purpan Service Endocrinologie, génétique et gynécologie médicale pédiatrique [CHU Toulouse] Centre de Physiopathologie Toulouse Purpan Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Geroscience and rejuvenation research center
• Publié dans Science Translational Medicine le 23/10/2020

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Résumé : Insulin resistance is a key event in type 2 diabetes onset and a major comorbidity of obesity. It results from a combination of fat excess-triggered defects, including lipotoxicity and metaflammation, but the causal mechanisms remain difficult to identify. Here, we report that hyperactivation of the tyrosine phosphatase SHP2 found in Noonan syndrome (NS) led to an unsuspected insulin resistance profile uncoupled from altered lipid management (for example, obesity or ectopic lipid deposits) in both patients and mice. Functional exploration of an NS mouse model revealed this insulin resistance phenotype correlated with constitutive inflammation of tissues involved in the regulation of glucose metabolism. Bone marrow transplantation and macrophage depletion improved glucose homeostasis and decreased metaflammation in the mice, highlighting a key role of macrophages. In-depth analysis of bone marrow-derived macrophages in vitro and liver macrophages showed that hyperactive SHP2 promoted a proinflammatory phenotype, modified resident macrophage homeostasis, and triggered monocyte infiltration. Consistent with a role of SHP2 in promoting inflammation-driven insulin resistance, pharmaceutical SHP2 inhibition in obese diabetic mice improved insulin sensitivity even better than conventional antidiabetic molecules by specifically reducing metaflammation and alleviating macrophage activation. Together, these results reveal that SHP2 hyperactivation leads to inflammation-triggered metabolic impairments and highlight the therapeutical potential of SHP2 inhibition to ameliorate insulin resistance.

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• Type de publi. : Article dans une revue
• Date de publi. : 28/04/2021
• Auteurs : Alemu GonsamoPhilippe CiaisB. MirallesStephen SitchWouter DorigoDanica LombardozziPierre FriedlingsteinJulia NabelDaniel S GollMichael O’sullivanAlmut ArnethPeter AnthoniAtul JainP. PeylinAlessandro Cescatti
• Organismes : School of Geography and earth sciences Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC Environnement, Ville, Société Université Lumière - Lyon 2 LabEx Intelligences des Mondes Urbains University of Exeter Department of Geodesy and Geoinformation [TU Wien] National Center for Atmospheric Research [Boulder] Laboratoire de Météorologie Dynamique (UMR 8539) Institut Pierre-Simon-Laplace Max Planck Institute for Meteorology Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Contrôles des cycles biogéochimiques terrestres College of Life and Environmental Sciences [Exeter] Institut für Meteorologie und Klimaforschung - Atmosphärische Umweltforschung Institute of Meteorology and Climate Research Department of Atmospheric Sciences [Urbana] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] JRC Institute for Environment and Sustainability
• Publié dans Global Change Biology le 25/10/2020

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Résumé : The rising atmospheric CO2 concentration leads to a CO2 fertilization effect on plants—that is, increased photosynthetic uptake of CO2 by leaves and enhanced water-use efficiency (WUE). Yet, the resulting net impact of CO2 fertilization on plant growth and soil moisture (SM) savings at large scale is poorly understood. Drylands provide a natural experimental setting to detect the CO2 fertilization effect on plant growth since foliage amount, plant water-use and photosynthesis are all tightly coupled in water-limited ecosystems. A long-term change in the response of leaf area index (LAI, a measure of foliage amount) to changes in SM is likely to stem from changing water demand of primary productivity in water-limited ecosystems and is a proxy for changes in WUE. Using 34-year satellite observations of LAI and SM over tropical and subtropical drylands, we identify that a 1% increment in SM leads to 0.15% (±0.008, 95% confidence interval) and 0.51% (±0.01, 95% confidence interval) increments in LAI during 1982‒1998 and 1999‒2015, respectively. The increasing response of LAI to SM has contributed 7.2% (±3.0%, 95% confidence interval) to total dryland greening during 1999‒2015 compared to 1982‒1998. The increasing response of LAI to SM is consistent with the CO2 fertilization effect on WUE in water-limited ecosystems, indicating that a given amount of SM has sustained greater amounts of photosynthetic foliage over time. The LAI responses to changes in SM from seven dynamic global vegetation models are not always consistent with observations, highlighting the need for improved process knowledge of terrestrial ecosystem responses to rising atmospheric CO2 concentration.

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• Type de publi. : Article dans une revue
• Date de publi. : 28/04/2021
• Auteurs : Guillaume GuérinChristelle LahayeMaryam HeydariMartin AutzenJan-Pieter BuylaertPierre GuibertMayank JainSebastian KreutzerLebrun BriceAndrew MurrayKristina ThomsenPetra UrbanováAnne Philippe
• Organismes : IRAMAT-Centre de recherche en physique appliquée à l’archéologie Géosciences Rennes IRAMAT-Centre de recherche en physique appliquée à l’archéologie IRAMAT-Centre de recherche en physique appliquée à l’archéologie Danmarks Tekniske Universitet = Technical University of Denmark Danmarks Tekniske Universitet = Technical University of Denmark IRAMAT-Centre de recherche en physique appliquée à l’archéologie Danmarks Tekniske Universitet = Technical University of Denmark IRAMAT-Centre de recherche en physique appliquée à l’archéologie Aberystwyth University IRAMAT-Centre de recherche en physique appliquée à l’archéologie Aarhus University [Aarhus] Danmarks Tekniske Universitet = Technical University of Denmark IRAMAT-Centre de recherche en physique appliquée à l’archéologie Laboratoire de Mathématiques Jean Leray
• Publié dans Geochronology le 10/09/2020

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Résumé : Abstract. Statistical analysis has become increasingly important in optically stimulated luminescence (OSL) dating since it has become possible to measure signals at the single-grain scale. The accuracy of large chronological datasets can benefit from the inclusion, in chronological modelling, of stratigraphic constraints and shared systematic errors. Recently, a number of Bayesian models have been developed for OSL age calculation; the R package “BayLum” presented herein allows different models of this type to be implemented, particularly for samples in stratigraphic order which share systematic errors. We first show how to introduce stratigraphic constraints in BayLum; then, we focus on the construction, based on measurement uncertainties, of dose covariance matrices to account for systematic errors specific to OSL dating. The nature (systematic versus random) of errors affecting OSL ages is discussed, based – as an example – on the dose rate determination procedure at the IRAMAT-CRP2A laboratory (Bordeaux). The effects of the stratigraphic constraints and dose covariance matrices are illustrated on example datasets. In particular, the benefit of combining the modelling of systematic errors with independent ages, unaffected by these errors, is demonstrated. Finally, we discuss other common ways of estimating dose rates and how they may be taken into account in the covariance matrix by other potential users and laboratories. Test datasets are provided as a Supplement to the reader, together with an R markdown tutorial allowing the reproduction of all calculations and figures presented in this study.

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Fichiers liés : gchron-3-229-2021.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/04/2021
• Auteurs : Émilie BoulangerNicolas LoiseauAlice ValentiniVéronique ArnalPierre BoisseryTony DejeanJulie DeterNacim GuellatiFlorian HolonJean-Baptiste JuhelPhilippe LenfantStéphanie ManelDavid Mouillot
• Organismes : Centre d’Ecologie Fonctionnelle et Evolutive MARine Biodiversity Exploitation and Conservation MARine Biodiversity Exploitation and Conservation SPYGEN [Le Bourget-du-Lac] Centre d’Ecologie Fonctionnelle et Evolutive Agence de l'eau Rhône Méditerranée Corse SPYGEN [Le Bourget-du-Lac] Andromède Océanologie MARine Biodiversity Exploitation and Conservation Andromède Océanologie MARine Biodiversity Exploitation and Conservation Centre de Formation et de Recherche sur les Environnements Méditérranéens Centre d’Ecologie Fonctionnelle et Evolutive MARine Biodiversity Exploitation and Conservation Institut universitaire de France
• Publié dans Proceedings of the Royal Society B: Biological Sciences le 25/10/2020

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Résumé : Although we are currently experiencing worldwide biodiversity loss, local species richness does not always decline under anthropogenic pressure. This conservation paradox may also apply in protected areas but has not yet received conclusive evidence in marine ecosystems. Here, we survey fish assemblages in six Mediterranean no-take reserves and their adjacent fishing grounds using environmental DNA (eDNA) while controlling for environmental conditions. We detect less fish species in marine reserves than in nearby fished areas. The paradoxical gradient in species richness is accompanied by a marked change in fish species composition under different managements. This dissimilarity is mainly driven by species that are often overlooked by classical visual surveys but detected with eDNA: cryptobenthic, pelagic, and rare fishes. These results do not negate the importance of reserves in protecting biodiversity but shed new light on how under-represented species groups can positively react to fishing pressure and how conservation efforts can shape regional biodiversity patterns.

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Fichiers liés : 83492.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/04/2021
• Auteurs : Benjamin ThoreauJoris GallandMaxime DelrueMarie NeuwirthAlain StepanianAnthony ChauvinAzeddine DellalOlivier NalletMelanie RorizMathilde DevauxJonathan LondonGonzague Martin-LecampAntoine FroissartNouara ArabBertrand FerronMarie-Helene GroffViviane QueyrelChristine LorutLucile RegardEmilie BerthouxGuillaume BayerCloé ComarmondBertrand LiogerArsène MékinianTali-Anne SzwebelThomas SenéBlanca Amador-BorreroOlivier ManginPierre O SellierVirginie SiguretStéphane MoulyJean-Philippe KevorkianDominique VodovarDamien Sène
• Organismes : Service de médecine interne et centre de référence des maladies rares [CHU Cochin] Institut Cochin Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Groupe Hospitalier Intercommunal Le Raincy-Montfermeil Groupe Hospitalier Intercommunal Le Raincy-Montfermeil Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Groupe Hospitalier Diaconesses Croix Saint-Simon Centre hospitalier de Pau Centre Hospitalier Intercommunal de Créteil Centre Hospitalier Intercommunal de Créteil Centre hospitalier de Sens Centre Hospitalier du Nord Mayenne Centre Hospitalier Universitaire de Nice Service de pneumologie [CHU Cochin] Service de pneumologie [CHU Cochin] Centre hospitalier Saint Joseph - Saint Luc [Lyon] Centre Hospitalier Privé Claude Galien - Ramsay Santé CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université - Faculté de Médecine UFR Sciences de la santé Simone Veil CHU Saint-Antoine [AP-HP] Service de médecine interne et centre de référence des maladies rares [CHU Cochin] Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Hôpital Lariboisière-Fernand-Widal [APHP] Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] Optimisation thérapeutique en Neuropsychopharmacologie Hôpital Lariboisière-Fernand-Widal [APHP]
• Publié dans Viruses le 01/11/2020

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Résumé : The incidence of pulmonary embolism (PE) is high during severe Coronavirus Disease 2019 (COVID-19). We aimed to identify predictive and prognostic factors of PE in non-ICU hospitalized COVID-19 patients. In the retrospective multicenter observational CLOTVID cohort, we enrolled patients with confirmed RT-PCR COVID-19 who were hospitalized in a medicine ward and also underwent a CT pulmonary angiography for a PE suspicion. Baseline data, laboratory biomarkers, treatments, and outcomes were collected. Predictive and prognostics factors of PE were identified by using logistic multivariate and by Cox regression models, respectively. A total of 174 patients were enrolled, among whom 86 (median [IQR] age of 66 years [55-77]) had post-admission PE suspicion, with 30/86 (34.9%) PE being confirmed. PE occurrence was independently associated with the lack of long-term anticoagulation or thromboprophylaxis (OR [95%CI], 72.3 [3.6-4384.8]) D-dimers ≥ 2000 ng/mL (26.3 [4.1-537.8]) and neutrophils ≥ 7.0 G/L (5.8 [1.4-29.5]). The presence of these two biomarkers was associated with a higher risk of PE (p = 0.0002) and death or ICU transfer (HR [95%CI], 12.9 [2.5-67.8], p < 0.01). In hospitalized non-ICU severe COVID-19 patients with clinical PE suspicion, the lack of anticoagulation, D-dimers ≥ 2000 ng/mL, neutrophils ≥ 7.0 G/L, and these two biomarkers combined might be useful predictive markers of PE and prognosis, respectively.

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Fichiers liés : viruses-13-00758-v2.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/04/2021
• Auteurs : Jean-Philippe Lucien GayonGang ChenPierre Lemaire
• Organismes : Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes Institut national polytechnique Clermont Auvergne National Sun Yat-sen University Recherche Opérationnelle pour les Systèmes de Production

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Fichiers liés : gcl21_roadef.pdf

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Source