Marine Portal

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Tangui BarréFabrice CarratClémence RamierHélène FontaineVincent Di BeoMorgane BureauCéline DorivalDominique LarreyElisabeth Delarocque-AstagneauPhilippe MathurinFabienne MarcellinVentzislava Petrov-SanchezCarole CagnotPatrizia CarrieriStanislas PolCamelia ProtopopescuLaurent AlricChloe PomesFabien ZoulimMarianne MaynardRoxane BaiLucie HucaultFrançois BaillyFrançois RaffiEric BillaudDavid BoutoilleMaeva LefebvreElisabeth André-GarnierPaul CalesIsabelle HubertAdrien LannesFrançoise LunelJérôme BoursierTarik AsselahNathalie BoyerNathalie GiuilyCorinne CastelnauGiovanna ScoazecEmilie RousseaudAnaïs Vallet-PichardPhilippe SogniVictor de LedinghenJuliette FoucherJean-Baptiste HiriartJancell M’bouyouMarie Irlès-DepéMarc BourlièreSi Nafa Si AhmedValérie OulesAlbert TranRodolphe AntyEve GelsiRégine TruchiDominique ThabutSaloua HammecheJoseph MoussaliXavier CausseBarbara de DieuleveultBrahim OuaraniDamien LabarrièreNathalie GanneVéronique Grando-LemairePierre NahonSéverine BruléBetul UlkerDominique GuyaderCaroline JezequelAudrey BrenerAnne LaligantAline RabotIsabelle RenardFrançois HabersetzerThomas BaumertMichel DoffoelCatherine MutterPauline Simo-NoumbissieEsma RaziJean-Pierre BronowickiHélène BarraudMouni BensenaneAbdelbasset NaniSarah Hassani-NaniMarie-Albertine BernardGeorges-Philippe PageauxMagda MeszarosSophie MetivierChristophe BureauThibault MoralesJean Marie PeronMarie Angèle RobicThomas DecaensMarine FaureBruno FroissartMarie-Noelle HilleretJean-Pierre ZarskiGhassan RiachiOdile GoriaFatima ParisHélène MontialouxVincent LeroyGiuliana AmaddeoAnne VarautMélanie SimoesRachida AmzalOlivier ChazouillièresTony AndreaniBénédicte AngoulevantAzeline ChevanceLawrence SerfatyDidier SamuelTeresa AntoniniAudrey CoillyJean-Charles Duclos-ValléeMariagrazia TateoArmand AbergelMaud ReymondChanteranne BrigitteBuchard BenjaminLéon MutiClaire GeistGuillaume ConroyRaphaëlle RiffaultIsabelle RosaCamille BarraultLaurent CostesHervé HagègeVéronique Loustaud-RattiPaul CarrierMaryline Debette-GratienGuillaume LassaillyElise LemaitreValérie CanvaSébastien DharancyAlexandre LouvetAnne MinelloMarianne LatournerieMarc BardouThomas MouillotLouis D’alterocheDidier BarbereauCharlotte NicolasLaure ElkriefAnaïs JaillaisJérôme GournayCaroline ChevalierIsabelle ArchambeaudSarah HabesIsabelle PortalMoana Gelu-SimeonEric SaillardMarie-Josée LafranceLucie CatherineFrederic ChauIsabelle GoderelClovis Lusivika-NzingaMarc-Antoine BellanceJonathan BelletPriscilla MonfaletJessica Chane-TengSephora BijaouiGrégory PannetierFrançois TéouléJérôme NicolFlorian SebalRafika BekhtiAnaïs BostonLaura NaillerGuillaume Le MeutAlpha DialloMarc BourlièreJérôme BoursierVictor de LedinghenSlim FouratiChantal HoussetPierre NahonGeorges-Philippe PageauxMathias BruyandLinda WittkopFabien ZoulimJessica Zucman-RossiMarianne L’hennaffMichèle Sizorn
• Organismes : Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Institut Pierre Louis d'Epidémiologie et de Santé Publique Service de santé publique [CHU Saint-Antoine] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Département d'hépatologie [CHU Cochin] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Institut Pierre Louis d'Epidémiologie et de Santé Publique Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Centre de recherche en épidémiologie et santé des populations Hôpital Raymond Poincaré [Garches] Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Agence Nationale de Recherches sur le Sida et les Hépatites Virales Agence Nationale de Recherches sur le Sida et les Hépatites Virales Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Département d'hépatologie [CHU Cochin] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
• Publié dans Journal of Cannabis Research le 03/12/2021

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Résumé : Background: Patients with chronic hepatitis C virus (HCV) infection are at greater risk of developing metabolic disorders. Obesity is a major risk factor for these disorders, and therefore, managing body weight is crucial. Cannabis use, which is common in these patients, has been associated with lower corpulence in various populations. However, this relationship has not yet been studied in persons with chronic HCV infection. Methods: Using baseline data from the French ANRS CO22 Hepather cohort, we used binary logistic and multinomial logistic regression models to test for an inverse relationship between cannabis use (former/current) and (i) central obesity (i.e., large waist circumference) and (ii) overweight and obesity (i.e., elevated body mass index (BMI)) in patients from the cohort who had chronic HCV infection. We also tested for relationships between cannabis use and both waist circumference and BMI as continuous variables, using linear regression models. Results: Among the 6348 participants in the study population, 55% had central obesity, 13.7% had obesity according to their BMI, and 12.4% were current cannabis users. After multivariable adjustment, current cannabis use was associated with lower risk of central obesity (adjusted odds ratio, aOR [95% confidence interval, CI]: 0.45 [0.37-0.55]), BMI-based obesity (adjusted relative risk ratio (aRRR) [95% CI]: 0.27 [0.19-0.39]), and overweight (aRRR [95% CI]: 0.47 [0.38-0.59]). This was also true for former use, but to a lesser extent. Former and current cannabis use were inversely associated with waist circumference and BMI. Conclusions: We found that former and, to a greater extent, current cannabis use were consistently associated with smaller waist circumference, lower BMI, and lower risks of overweight, obesity, and central obesity in patients with chronic HCV infection. Longitudinal studies are needed to confirm these relationships and to assess the effect of cannabis use on corpulence and liver outcomes after HCV cure. Trial registration: ClinicalTrials.gov identifier: NCT01953458 .

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Fichiers liés : s42238-022-00138-9.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 04/11/2022
• Auteurs : Sofie VrankenMarine RobuchonStefanie DekeyzerIgnacio BárbaraInka BartschAurélie BlanfunéCharles-François BoudouresqueWim DecockChristophe DestombeBruno de ReviersPilar Díaz-TapiaAnne HerbstRomain JulliardRolf KarezPriit KersenStacy Krueger-HadfieldRalph KuhlenkampAkira PetersViviana PeñaCristina Piñeiro-CorbeiraFabio RindiFlorence RousseauJan RuenessHendrik SchubertKjersti SjøtunMarta SansónDan SmaleThierry ThibautMyriam ValeroLeen VandepitteBart VanhoorneAlba VergésMarc VerlaqueChristophe VieiraLine Le GallFrederik LeliaertOlivier de Clerck
• Organismes : Biologie évolutive et écologie des algues = Evolutionary Biology and Ecology of Algae

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Résumé : Abstract. The analysis of biological and ecological traits has a long history in evolutionary and ecological research. However, trait data are often scattered and standardised terminology that transcends taxonomic and biogeographical context are generally missing. As part of the development of a global trait database of marine species, we collated trait information for European seaweeds and structured the data within the standardised framework of the World Register of Marine Species (WoRMS). We collected 45,175 records for 21 biologically and ecologically relevant traits of seaweeds. This resulted in a trait database for 1,745 European seaweed species of which more than half (56 %) of the records were documented at the species level, while the remaining 44 % was documented at a higher taxonomic level and subsequently inherited at lower levels. The trait database for European seaweeds will serve as a foundation for future research on diversity and evolution of seaweeds, and their responses to global changes. The data will contribute to developing detailed trait-based ecosystem models, and will be an important tool to inform marine conservation policies. The data is publicly accessible through the AlgaeTraits portal, algaetraits.org, doi: https://doi.org/10.14284/574, (AlgaeTraits, 2022).

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 28/10/2022
• Auteurs : Sofie VrankenMarine RobuchonStefanie DekeyzerIgnacio BárbaraInka BartschAurélie BlanfunéCharles-François BoudouresqueWim DecockChristophe DestombeBruno de ReviersPilar Díaz-TapiaAnne HerbstRomain JulliardRolf KarezPriit KersenStacy Krueger-HadfieldRalph KuhlenkampAkira PetersViviana PeñaCristina Piñeiro-CorbeiraFabio RindiFlorence RousseauJan RuenessHendrik SchubertKjersti SjøtunMarta SansónDan SmaleThierry ThibautMyriam ValeroLeen VandepitteBart VanhoorneAlba VergésMarc VerlaqueChristophe VieiraLine Le GallFrederik LeliaertOlivier de Clerck
• Organismes : Biologie évolutive et écologie des algues = Evolutionary Biology and Ecology of Algae Biologie évolutive et écologie des algues = Evolutionary Biology and Ecology of Algae

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Résumé : Abstract. The analysis of biological and ecological traits has a long history in evolutionary and ecological research. However, trait data are often scattered and standardised terminology that transcends taxonomic and biogeographical context are generally missing. As part of the development of a global trait database of marine species, we collated trait information for European seaweeds and structured the data within the standardised framework of the World Register of Marine Species (WoRMS). We collected 45,175 records for 21 biologically and ecologically relevant traits of seaweeds. This resulted in a trait database for 1,745 European seaweed species of which more than half (56 %) of the records were documented at the species level, while the remaining 44 % was documented at a higher taxonomic level and subsequently inherited at lower levels. The trait database for European seaweeds will serve as a foundation for future research on diversity and evolution of seaweeds, and their responses to global changes. The data will contribute to developing detailed trait-based ecosystem models, and will be an important tool to inform marine conservation policies. The data is publicly accessible through the AlgaeTraits portal, algaetraits.org, doi: https://doi.org/10.14284/574, (AlgaeTraits, 2022).

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• Type de publi. : Article dans une revue
• Date de publi. : 27/10/2022
• Auteurs : Ian GralnekMarine Camus DubocJuan Carlos Garcia-PaganLorenzo FuccioJohn Gásdal KarstensenTomas HuclIvan JovanovicHalim AwadieVirginia Hernandez-GeaMarcel TantauAlanna EbigboMostafa IbrahimJiannis VlachogiannakosMarc BurgmansRobyn RosascoKonstantinos Triantafyllou
• Organismes : Université de Niš Institut d'Investigacions Biomèdiques August Pi i Sunyer Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas Health Care Provider of the European Reference Network onRare Liver Disorders
• Publié dans Endoscopy le 22/10/2020

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Résumé : Main Recommendations 1 ESGE recommends that patients with compensated advanced chronic liver disease (ACLD; due to viruses, alcohol, and/or nonobese [BMI < 30 kg/m2] nonalcoholic steatohepatitis) and clinically significant portal hypertension (hepatic venous pressure gradient [HVPG] > 10 mmHg and/or liver stiffness by transient elastography > 25 kPa) should receive, if no contraindications, nonselective beta blocker (NSBB) therapy (preferably carvedilol) to prevent the development of variceal bleeding.Strong recommendation, moderate quality evidence. 2 ESGE recommends that in those patients unable to receive NSBB therapy with a screening upper gastrointestinal (GI) endoscopy that demonstrates high risk esophageal varices, endoscopic band ligation (EBL) is the endoscopic prophylactic treatment of choice. EBL should be repeated every 2–4 weeks until variceal eradication is achieved. Thereafter, surveillance EGD should be performed every 3–6 months in the first year following eradication.Strong recommendation, moderate quality evidence. 3 ESGE recommends, in hemodynamically stable patients with acute upper GI hemorrhage (UGIH) and no history of cardiovascular disease, a restrictive red blood cell (RBC) transfusion strategy, with a hemoglobin threshold of ≤ 70 g/L prompting RBC transfusion. A post-transfusion target hemoglobin of 70–90 g/L is desired.Strong recommendation, moderate quality evidence. 4 ESGE recommends that patients with ACLD presenting with suspected acute variceal bleeding be risk stratified according to the Child–Pugh score and MELD score, and by documentation of active/inactive bleeding at the time of upper GI endoscopy.Strong recommendation, high quality of evidence. 5 ESGE recommends the vasoactive agents terlipressin, octreotide, or somatostatin be initiated at the time of presentation in patients with suspected acute variceal bleeding and be continued for a duration of up to 5 days.Strong recommendation, high quality evidence. 6 ESGE recommends antibiotic prophylaxis using ceftriaxone 1 g/day for up to 7 days for all patients with ACLD presenting with acute variceal hemorrhage, or in accordance with local antibiotic resistance and patient allergies.Strong recommendation, high quality evidence. 7 ESGE recommends, in the absence of contraindications, intravenous erythromycin 250 mg be given 30–120 minutes prior to upper GI endoscopy in patients with suspected acute variceal hemorrhage.Strong recommendation, high quality evidence. 8 ESGE recommends that, in patients with suspected variceal hemorrhage, endoscopic evaluation should take place within 12 hours from the time of patient presentation provided the patient has been hemodynamically resuscitated.Strong recommendation, moderate quality evidence. 9 ESGE recommends EBL for the treatment of acute esophageal variceal hemorrhage (EVH).Strong recommendation, high quality evidence. 10 ESGE recommends that, in patients at high risk for recurrent esophageal variceal bleeding following successful endoscopic hemostasis (Child–Pugh C ≤ 13 or Child–Pugh B > 7 with active EVH at the time of endoscopy despite vasoactive agents, or HVPG > 20 mmHg), pre-emptive transjugular intrahepatic portosystemic shunt (TIPS) within 72 hours (preferably within 24 hours) must be considered.Strong recommendation, high quality evidence. 11 ESGE recommends that, for persistent esophageal variceal bleeding despite vasoactive pharmacological and endoscopic hemostasis therapy, urgent rescue TIPS should be considered (where available).Strong recommendation, moderate quality evidence. 12 ESGE recommends endoscopic cyanoacrylate injection for acute gastric (cardiofundal) variceal (GOV2, IGV1) hemorrhage.Strong recommendation, high quality evidence. 13 ESGE recommends endoscopic cyanoacrylate injection or EBL in patients with GOV1-specific bleeding.Strong recommendations, moderate quality evidence. 14 ESGE suggests urgent rescue TIPS or balloon-occluded retrograde transvenous obliteration (BRTO) for gastric variceal bleeding when there is a failure of endoscopic hemostasis or early recurrent bleeding.Weak recommendation, low quality evidence. 15 ESGE recommends that patients who have undergone EBL for acute EVH should be scheduled for follow-up EBLs at 1- to 4-weekly intervals to eradicate esophageal varices (secondary prophylaxis).Strong recommendation, moderate quality evidence. 16 ESGE recommends the use of NSBBs (propranolol or carvedilol) in combination with endoscopic therapy for secondary prophylaxis in EVH in patients with ACLD.Strong recommendation, high quality evidence.

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• Type de publi. : Rapport
• Date de publi. : 14/10/2022
• Auteurs : Sofie VrankenMarine RobuchonStefanie DekeyzerIgnacio BárbaraInka BartschAurélie BlanfunéCharles-François BoudouresqueWim DecockChristophe DestombeBruno de ReviersPilar Díaz-TapiaAnne HerbstRomain JulliardRolf KarezPriit KersenStacy Krueger-HadfieldRalph KuhlenkampAkira PetersViviana PeñaCristina Piñeiro-CorbeiraFabio RindiFlorence RousseauJan RuenessHendrik SchubertKjersti SjøtunMarta SansónDan SmaleThierry ThibautMyriam ValeroLeen VandepitteBart VanhoorneAlba VergésMarc VerlaqueChristophe VieiraLine Le GallFrederik LeliaertOlivier de Clerck
• Organismes : European Commission - Joint Research Centre [Ispra] Universidade da Coruña Alfred-Wegener-Institute Helmholtz Centre for Polar and Marine Research, Biologische Anstalt Helgoland, Helgoland, Germany Institut méditerranéen d'océanologie Institut méditerranéen d'océanologie Biologie évolutive et écologie des algues = Evolutionary Biology and Ecology of Algae Institut de Systématique, Evolution, Biodiversité Centre d'Ecologie et des Sciences de la COnservation University of Alabama at Birmingham [ Birmingham] Centre d'Etude et de Valorisation des Algues University of Aberdeen Bezhin Rosko Universidade da Coruña Institut de Systématique, Evolution, Biodiversité Institut de Systématique, Evolution, Biodiversité

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Résumé : Abstract. The analysis of biological and ecological traits has a long history in evolutionary and ecological research. However, trait data are often scattered and standardised terminology that transcends taxonomic and biogeographical context are generally missing. As part of the development of a global trait database of marine species, we collated trait information for European seaweeds and structured the data within the standardised framework of the World Register of Marine Species (WoRMS). We collected 45,175 records for 21 biologically and ecologically relevant traits of seaweeds. This resulted in a trait database for 1,745 European seaweed species of which more than half (56 %) of the records were documented at the species level, while the remaining 44 % was documented at a higher taxonomic level and subsequently inherited at lower levels. The trait database for European seaweeds will serve as a foundation for future research on diversity and evolution of seaweeds, and their responses to global changes. The data will contribute to developing detailed trait-based ecosystem models, and will be an important tool to inform marine conservation policies. The data is publicly accessible through the AlgaeTraits portal, algaetraits.org, doi: https://doi.org/10.14284/574, (AlgaeTraits, 2022).

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Fichiers liés : Vranken et al. - 2022 - AlgaeTraits a trait database for (European) seawe.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/06/2022
• Auteurs : Guillaume PlaisanceMarine Bouin-Portal
• Organismes : Université de Bordeaux Institut de Recherche en Gestion des Organisations Institut de Recherche en Gestion des Organisations Université de Bordeaux

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Résumé : Aujourd’hui, le concept de soutenabilité dans le secteur public est essentiellement ramené à sa dimension financière. Cependant, ce focus sur les aspects budgétaires et financiers de la soutenabilité nie le caractère global du concept. L’objectif de cette communication est donc de retravailler le concept de soutenabilité dans le contexte français du management public grâce à une méthodologie bibliométrique. Elle nous permet de confronter la littérature internationale à la littérature française afin de reconstituer les dimensions et les associations pertinentes de la soutenabilité. A partir d'une étude des mots-clefs de la littérature internationale et au filtre de la définition de la soutenabilité proposée par l'ISO, l'analyse bibliométrique ouvre la voie à une réflexion française dédiée à la soutenabilité.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Georges AadBraden Keim AbbottDale AbbottAdam Abed AbudKira AbelingDeshan Kavishka AbhayasingheHaider AbidiAsmaa AboulhormaHalina AbramowiczHenso AbreuYiming AbulaitiAngel AbuslemeBobby Samir AcharyaBaida AchkarLennart AdamClaire Adam BourdariosLeszek AdamczykLukas AdamekSagar AddepalliJahred AdelmanAytul AdiguzelSofia Adorni Braccesi ChiassiTim AdyeA.A. AffolderTony AffolderYoav AfikMerve Nazlim AgarasJinky AgarwalaAnamika AggarwalCatalin AgheorghieseiJuan Antonio Aguilar SaavedraAmmara AhmadFaig AhmadovWaleed Syed AhmedXiaocong AiGiulio AielliIakov AizenbergMelike AkbiyikTorsten AkessonAndrei AkimovKonie Al KhouryGian Luigi AlberghiJustin AlbertPietro AlbicoccoM.J. Alconada VerziniSara AlderweireldtMartin AleksaI.N. AleksandrovCalin AlexaTheodoros AlexopoulosAlice AlfonsiFabrizio AlfonsiMuhammad AlhroobBabar AliShahzad AliMalik AlievGianluca AlimontiCorentin AllaireBenedict AllbrookePhilip Patrick AllportAlberto AloisioFrancisco AlonsoCristiano AlpigianiElio Alunno CameliaManuel Alvarez EstevezMariagrazia AlviggiYara Do Amaral CoutinhoAlessandro AmblerLuca AmbrozChristoph AmelungDante AmideiSusana Patricia Amor dos SantosSimone AmorosoKieran Robert AmosCherifa Sabrina AmroucheViktor AnanievChristos AnastopoulosNansi AndariTimothy Robert AndeenJohn Kenneth AndersStefio Yosse AndreanAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelMatthew Thomas AnthonyEgor AntipovMario AntonelliDaniel Joseph AntrimFabio AnulliMasato AokiJavier Alberto Aparisi PozoMarco AparoLudovica Aperio BellaChristian AppeltNordin Aranzabal BarrioVictor Araujo FerrazChiara ArcangelettiAyana Tamu ArceEloisa ArenaJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingAaron James ArmbrusterOlivier ArnaezHannah ArnoldZulit Paola Arrubarrena TameGiacomo ArtoniHaruka AsadaKanae AsaiShoji AsaiNedaa Alexandra AsbahEleni Myrto AsimakopoulouJihad AssahsahKetevi Adikle AssamaganRobert AstalosRyan Justin AtkinMarkus Julian AtkinsonNaim Bora AtlayHicham AtmaniPrachi AtmasiddhaKamil AugstenSilvia AuricchioVolker Andreas AustrupGal AvnerGiuseppe AvolioMohamad Kassem AyoubGeorges AzuelosDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuKarl Filip BackmanAnthony BadeaPaolo BagnaiaMarzieh BahmaniAdam BaileyVirginia BaileyJohn BainesChristos BakalisKeith BakerPepijn Johannes BakkerEvelin BakosDebottam Bakshi GuptaShyam BalajiRahul BalasubramanianEvgenii BaldinPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasJohannes BalzElzbieta BanasMarilena BandieramonteAnjishnu BandyopadhyayShubham BansalLiron BarakElisabetta BarberioDario BarberisMarlon Benoit BarberoGregory BarbourKevin Nicholas BarendsTeresa BarillariMartin BarisitsJason Tyler Colt BarkelooTim BarklowMichael BarnettPetr BaronA. BaroncelliToni BaroncelliGaetano BaroneAlan BarrLaura Barranco NavarroFernando Barreiro AlonsoJoao Barreiro Guimaraes da CostaUriel BarronSergey BarsovFalk BartelsRainer BartoldusGiovanni BartoliniAdam Edward BartonPavol BartosArtem BasalaevAlexander BasanMarta Baselga BacarditInna BashtaAhmed BassalatMatthew Joseph BassoCandice Ruth BassonRichard BatesSouad BatlamousRichard BatleyBinish BatoolMarco BattagliaMatteo BauceFlorian BauerPatrick BauerArif BayirliJames BeachamTristan BeauPierre-Hugues BeaucheminFabian BechererPhilip BechtleHans Peter BeckKathrin BeckerCyril Pascal BecotAndrew BeddallVadim BednyakovChris BeeLars BeemsterThomas BeermannMarcia BegalliMichael BegelArabinda BeheraJanna Katharina BehrCristovao Beirao da Cruz E SilvaJoshua Falco BeirerFlorian BeisiegelMohamed BelfkirGideon BellaLorenzo BellagambaAlain BellerivePanagiotis BellosKonstantin BeloborodovKonstantin BelotskiyNikita BelyaevDriss BenchekrounYan BenhammouDoug BenjaminMathieu BenoitJ.R. BensingerStan BentvelsenLydia Audrey BeresfordMatteo Mario BerettaDavid BergeElin Bergeaas KuutmannNicolas BergerBenedikt Ludwig BergmannJuerg BeringerSimon BerlendisGregorio BernardiCatrin BerniusFlorian Urs BernlochnerTracey BerryPeter BertaIain BertramOlga Bessidskaia BylundSiegfried BethkeAlessandra BettiAdrian BevanSomadutta BhattaDeb Sankar BhattacharyaPrajita BhattaraiVallary Shashikant BhopatkarRunyu BiRan BiRiccardo Maria BianchiOtmar BiebelRafal BielskiNicolo Vladi BiesuzMichela BigliettiT.R. V. BilloudMarcello BindiAhmet BingulCesare BiniSilvia BiondiAlessandro BiondiniCallum Jacob Birch-SykesGareth Adam BirdMattias BirmanTobias BisanzJyoti Prakash BiswalDiptaparna BiswasAlexander BitadzeKristian BjoerkeIngo BlochCraig BlockerAndrew James BlueUlla BlumenscheinJulian BlumenthalGerjan BobbinkViktor BobrovnikovMichael BoehlerDanijela BogavacAlexander BogdanchikovChristian BohmVeronique BoisvertPetar BokanTomasz BoldMarco BombenMarcella BonaMaarten BoonekampCallum Dale BoothAlbert Gyorgy BorbelyHanna Maria Borecka-BielskaLucas Santiago BorgnaGuennadi BorissovDaniela BortolettoDavide BoscheriniMartine Fernandez-BosmanJ.D. Bossio SolaKhalil BouaoudaJoseph BoudreauE.V. Bouhova-ThackerDjamel Eddine BoumedieneRomain BouquetAntonio BoveiaJamie BoydDiallo BoyeIgor BoykoJuraj BracinikNihal BrahimiGerhard Immanuel BrandtOleg BrandtFrued Erik BrarenBenjamin Paul BrauJ.E. BrauWill Breaden MaddenKurt BrendlingerRoy Schimmel BrenerLydia BrennerRichard BrennerShikma BresslerBernard BrickweddeDavid BrittonDaniel Andreas BritzgerIan BrockGustaaf BrooijmansWilliam King BrooksElizabeth BrostPawel Bruckman de RenstromBen BruersDusan BrunckoAlessia BruniGraziano BruniMarco BruschiNello BruscinoLene Kristian BryngemarkTrygve BuanesQuentin BuatPeter BuchholzAndy BuckleyIoulian BudagovMagnar Kopangen BuggeOleg BulekovBrendon BullardSergey BurdinCarsten BurgardAngela Maria BurgerBlake Oliver BurghgraveJ.T. P. BurrCharles BurtonJackson Carl BurzynskiElena Laura BuschVolker BuescherPeter John BusseyJohn Mark ButlerCraig Macleod ButtarJonathan ButterworthWill ButtingerCarlos Josue Buxo VazquezAlexey BuzykaevGrazia CabrasSusana Cabrera UrbanDavide CaforioHuacheng CaiYuchen CaiValentina CairoOrhan CakirNoemi CalacePaolo CalafiuraGiovanni CalderiniPhilippe CalfayanGiuseppe CalleaLuiz CalobaDavid CalvetSamuel CalvetThomas Philippe CalvetMilene CalvettiReina Coromoto Camacho ToroStefano CamardaDaniel Camarero MunozPaolo CamarriMaria Teresa CamerlingoDavid CameronClement CamincherMario CampanelliAlessandra CamplaniVincenzo CanaleAuriane CanesseMarc Bret CanoJosu Cantero GarciaYumeng CaoFrancesca CapocasaMarcella CapuaAntonio CarboneRoberto CardarelliJuan Carlos CardenasFabio CardilloGiovandomenico CarducciTancredi CarliGiampaolo CarlinoB.T. CarlsonEvan Michael CarlsonLeonardo CarminatiMaria CarnesaleSascha CaronEdson Carquin LopezSonia CarraGiuseppe CarrattaJ.W. S. CarterThomas Michael CarterDiego CasadeiPilar Casado LechugaAlbert Francis CashaEmma Grace CastigliaFlorencia Luciana CastilloLucia Castillo GarciaVictoria Castillo GimenezNuno CastroAndrea CatinaccioJames CatmoreViviana CavaliereNoemi CavalliVincenzo CavasinniEmre CelebiFederico CelliMartino Salomone CentonzeKarel CernyAugusto Santiago CerqueiraAlex CerriLucio CerritoFabio CeruttiAlberto CervelliSerkant CetinZakaria ChadiDhiman ChakrabortyMikael ChalaJay ChanTerry Ws ChanWai Yuen ChanJohn Derek ChapmanBakar ChargeishviliDave CharltonThomas Paul CharmanMeghranjana ChatterjeeSergei ChekanovSergey ChekulaevG.A. ChelkovAndy ChenBoping ChenCharlie ChenCheng ChenHuirun ChenHucheng ChenJing ChenJiayi ChenShion ChenShenjian ChenXiang ChenXin ChenYe ChenAlkaid ChengHok Chuen Tom ChengAlexander CheplakovEvgeniya CheremushkinaElizaveta CherepanovaRajaa Cherkaoui El MoursliElliott CheuKingman CheungLaurent ChevalierVitaliano ChiarellaGiorgio ChiarelliGabriele ChiodiniAndrew Stephen ChisholmAdrian ChitanJustin ChiuMihail ChizhovKyungeon ChoiArthur ChomontYuan-Tang ChouE.Y. S. ChowTasnuva ChowdhuryLawrence Davou ChristopherMing Chung ChuXiaotong ChuJiri ChudobaJanusz ChwastowskiDavide CieriKrzysztof CieslaVladimir CindroAlessandra CiocioFrancesco CirottoZ.H. CitronMauro CitterioDan Andrei CiubotaruBianca Monica CiunguAllan ClarkPhilip ClarkJose Manuel Clavijo ColumbieSavannah ClawsonChristophe ClementLuca ClissaYann CoadouMarina CobalAndrea CoccaroR.F. Coelho BarrueRafael Coelho Lopes de SaSimone CoelliHadar CohenA.E. C. 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JonesJelena JovicevicXiangyang JuJohannes JunggeburthAurelio Juste RozasSonia KabanaAnna KaczmarskaMarumi KadoHarris KaganMichael Aaron KaganAlan Mathew KahnAbraham KahnChristian KahraToshiaki KajiEnrique Kajomovitz MustNilotpal KakatiWill KalderonAndrey KamenshchikovNathan Jihoon KangYuya KanoDeepak KarKla KaravaMohammad KareemEfstathios KarentzosIoannis KarkaniasSergey KarpovZoya KarpovaVato KartvelishviliAndrei KaryukhinEirini KasimiChikuma KatoJudith KatzySandeep KaurKentaro KawadeKiyotomo KawagoeTomomi KawaguchiTatsuo KawamotoGen KawamuraEllis KayF.I. KayaColette KayaStergios KazakosVassili KazaninYan KeJames Michael KeaveneyRichard KeelerGustavs KehrisJohn Stakely KellerAidan Sean KellyDaniel Christopher KelseyJacob Julian KempsterJames Andrew KendrickKiley Elizabeth KennedyOldrich KepkaSusanne KerstenBorut Paul KersevanS. Ketabchi HaghighatMykola KhandogaAlexander KhanovAlexey KharlamovTatyana KharlamovaElham E. KhodaTeng Jian KhooGia KhoriauliEvgeny KhramovJ. KhubuaDjemal KhubuaMoritz KiehnAaron Joseph KilgallonEunchong KimYoung-Kee KimNaoki KimuraAndreas KirchhoffDavid KirchmeierChristian KirfelJulie KirkAndrei KiryuninTomoe KishimotoDylan Perry KisliukChara KitsakiOleh KivernykMartin KlassenChristoph Thomas KleinLucas KleinMatthew Henry KleinMax KleinUta KleinPawel Jan KlimekAlexei KlimentovFabian KlimpelTobias KlinglTatiana KlioutchnikovaFelix Fidelio KlitznerPeter KluitStefan KluthEmmerich KneringerTimothy Michael KnightAndrea Helen KnueDai KobayashiRen KobayashiMartin KocianTakafumi KodamaPeter KodysD.M. KoeckDaniela KockPhilipp KonigThomas KoffasNicolas KoehlerMathis KolbIro KoletsouTomas KomarekKarsten KoenekeA.X. Y. 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• Organismes : Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont AstroParticule et Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers AstroParticule et Cosmologie Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
• Publié dans JHEP le 17/10/2021

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Résumé : A direct search for Higgs bosons produced via vector-boson fusion and subsequently decaying into invisible particles is reported. The analysis uses 139 fb$^{−1}$ of pp collision data at a centre-of-mass energy of $ \sqrt{s} $ = 13 TeV recorded by the ATLAS detector at the LHC. The observed numbers of events are found to be in agreement with the background expectation from Standard Model processes. For a scalar Higgs boson with a mass of 125 GeV and a Standard Model production cross section, an observed upper limit of 0.145 is placed on the branching fraction of its decay into invisible particles at 95% confidence level, with an expected limit of 0.103. These results are interpreted in the context of models where the Higgs boson acts as a portal to dark matter, and limits are set on the scattering cross section of weakly interacting massive particles and nucleons. Invisible decays of additional scalar bosons with masses from 50 GeV to 2 TeV are also studied, and the derived upper limits on the cross section times branching fraction decrease with increasing mass from 1.0 pb for a scalar boson mass of 50 GeV to 0.1 pb at a mass of 2 TeV.[graphic not available: see fulltext]

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• Type de publi. : Article dans une revue
• Date de publi. : 08/06/2021
• Auteurs : Maud SotyJustine Vily-PetitAshley Castellanos-JankiewiczOmar Guzman-QuevedoMargaux RaffinSamantha ClarkMarine SilvaAmandine Gautier-SteinDaniela CotaGilles Mithieux
• Organismes : Nutrition, diabète et cerveau Université de Lyon Université Claude Bernard Lyon 1 Nutrition, diabète et cerveau Université de Lyon Université Claude Bernard Lyon 1 Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Nutrition, diabète et cerveau Université de Lyon Université Claude Bernard Lyon 1 Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Nutrition, diabète et cerveau Université de Lyon Université Claude Bernard Lyon 1 Nutrition, diabète et cerveau Université de Lyon Université Claude Bernard Lyon 1 Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Nutrition, diabète et cerveau Université de Lyon Université Claude Bernard Lyon 1
• Publié dans Neuroendocrinology le 31/10/2020

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Résumé : Introduction: Intestinal gluconeogenesis (IGN) exerts metabolic benefits in energy homeostasis via the neural sensing of portal glucose. Objective: The aim of this work was to determine central mechanisms involved in the effects of IGN on the control of energy homeostasis. Methods: We investigated the effects of glucose infusion into the portal vein, at a rate that mimics IGN, in conscious wild-type, leptin-deficient Ob/Ob and calcitonin gene-related peptide (CGRP)-deficient mice. Results: We report that portal glucose infusion decreases food intake and plasma glucose and induces in the hypothalamic arcuate nucleus (ARC) the phosphorylation of STAT3, the classic intracellular messenger of leptin signaling. This notably takes place in POMC-expressing neurons. STAT3 phosphorylation does not require leptin, since portal glucose effects are observed in leptin-deficient Ob/Ob mice. We hypothesized that the portal glucose effects could require CGRP, a neuromediator previously suggested to suppress hunger. In line with this hypothesis, neither the metabolic benefits nor the phosphorylation of STAT3 in the ARC take place upon portal glucose infusion in CGRP-deficient mice. Moreover, intracerebroventricular injection of CGRP activates hypothalamic phosphorylation of STAT3 in mice, and CGRP does the same in hypothalamic cells. Finally, no metabolic benefit of dietary fibers (known to depend on the induction of IGN), takes place in CGRP-deficient mice. Conclusions: CGRP-induced phosphorylation of STAT3 in the ARC is part of the neural chain determining the hunger-modulating and glucose-lowering effects of IGN/portal glucose.

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Fichiers liés : Neuroendocrinol509230.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 11/01/2021
• Auteurs : Flore SinetMaud SotyJuliane ZemdegsBruno GuiardJudith EstradaGaël MalleretMarine SilvaGilles MithieuxAmandine Gautier-Stein
• Organismes : Nutrition, diabète et cerveau Université Claude Bernard Lyon 1 Université de Lyon Nutrition, diabète et cerveau Université Claude Bernard Lyon 1 Université de Lyon Centre de Recherches sur la Cognition Animale - UMR5169 Université Toulouse III - Paul Sabatier Centre de Recherches sur la Cognition Animale - UMR5169 Université Toulouse III - Paul Sabatier Nutrition, diabète et cerveau Université Claude Bernard Lyon 1 Université de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Nutrition, diabète et cerveau Université Claude Bernard Lyon 1 Université de Lyon Nutrition, diabète et cerveau Université Claude Bernard Lyon 1 Université de Lyon Nutrition, diabète et cerveau Université Claude Bernard Lyon 1 Université de Lyon
• Publié dans Neuroendocrinology le 31/10/2020

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Résumé : Introduction: Several studies have suggested that diet, especially one enriched in microbiota-fermented fibers or fat, regulates behavior. The underlying mechanisms are currently unknown. We previously reported that certain macronutrients (fermentable fiber and protein) regulate energy homeostasis via the activation of intestinal gluconeogenesis (IGN), which generates a neural signal to the brain. We hypothesized that these nutriments might control behavior using the same gut-brain circuit. Methods: Wild-type and IGN-deficient mice were fed chow or diets enriched in protein or fiber. Changes in their behavior were assessed using suited tests. Hippocampal neurogenesis, extracellular levels of serotonin and protein expression levels were assessed by immunofluorescence, in vivo dialysis or western-blotting respectively. Rescue of IGN was performed by infusing glucose in the portal vein of IGN-deficient mice. Results: We show here that both fiber- and protein-enriched diets exert beneficial actions on anxiety-like and depressive-like behaviors. These benefits do not occur in mice lacking IGN. Consistently, IGN-deficient mice display hallmarks of depressive-like disorders, including decreased hippocampal neurogenesis, basal hyperactivity and deregulation of the hypothalamic-pituitary-adrenal axis, which are associated with increased expression of the precursor of corticotropin releasing hormone in the hypothalamus and decreased expression of the glucocorticoid receptor in the hippocampus. These neurobiological alterations are corrected by portal glucose infusion mimicking IGN. Conclusion: IGN translates nutritional information allowing the brain to finely coordinate energy metabolism and behavior.

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Fichiers liés : NeuroEndocrinol514289.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2021
• Auteurs : Tangui BarréStanislas PolClémence RamierVincent Di BeoFabrice CarratMorgane BureauMarc BourlièreCéline DorivalLawrence SerfatyTarik AsselahJérôme BoursierFabienne MarcellinPatrizia M. CarrieriHélène FontaineCamelia ProtopopescuLaurent AlricDelphine BonnetVirginie Payssan-SicartChloe PomesFabien ZoulimMarianne MaynardRoxane BaiLucie HucaultFrançois BaillyFrançois RaffiEric BillaudDavid BoutoilleMaeva LefebvreElisabeth André-GarnierPaul CalèsIsabelle HubertAdrien LannesFrançoise LunelNathalie BoyerNathalie GiuilyCorinne CastelnauGiovanna ScoazecEmilie RousseaudAnaïs Vallet-PichardPhilippe SogniVictor De LedinghenJuliette FoucherJean-Baptiste HiriartJancell M'BouyouMarie Irlès-DepéSi Nafa Si AhmedValérie OulesAlbert TranRodolphe AntyEve GelsiRégine TruchiDominique ThabutSaloua HammecheJoseph MoussaliXavier CausseBarbara De DieuleveultBrahim OuaraniDamien LabarrièreNathalie GanneVéronique Grando-LemairePierre NahonSéverine BruléBetul UlkerDominique GuyaderCaroline JezequelAudrey BrenerAnne LaligantAline RabotIsabelle RenardFrançois HabersetzerThomas BaumertMichel DoffoelCatherine MutterPauline Simo-NoumbissieEsma RaziJean-Pierre BronowickiHélène BarraudMouni BensenaneAbdelbasset NaniSarah Hassani-NaniMarie-Albertine BernardGeorges-Philippe PageauxDominique LarreyMagda MeszarosSophie MetivierChristophe BureauThibault MoralesJean Marie PeronMarie Angèle RobicThomas DecaensMarine FaureBruno FroissartMarie-Noelle HilleretJean-Pierre ZarskiGhassan RiachiOdile GoriaFatima ParisHélène MontialouxVincent LeroyGiuliana AmaddeoAnne VarautMélanie SimoesRachida AmzalOlivier ChazouillièresTony AndreaniBénédicte AngoulevantAzeline ChevanceDidier SamuelTeresa AntoniniAudrey CoillyJean-Charles Duclos ValléeMariagrazia TateoArmand AbergelMaud ReymondChanteranne BrigitteBuchard BenjaminLéon MutiClaire GeistGuillaume ConroyRaphaëlle RiffaultIsabelle RosaCamille BarraultLaurent CostesHervé HagègeVéronique Loustaud-RattiPaul CarrierMaryline Debette-GratienPhilippe MathurinGuillaume LassaillyElise LemaitreValérie CanvaSébastien DharancyAlexandre LouvetAnne MinelloMarianne LatournerieMarc BardouThomas MouillotLouis d'AlterocheDidier BarbereauCharlotte NicolasLaure ElkriefAnaïs JaillaisJérôme GournayCaroline ChevalierIsabelle ArchambeaudSarah HabesIsabelle PortalMoana Gelu-SimeonEric SaillardMarie-Josée LafranceLucie Catherine
• Organismes : Nutrition, obésité et risque thrombotique Service d'hépatologie médicale [CHU Cochin] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Service d'hépato-gastro-entérologie Institut Pierre Louis d'Epidémiologie et de Santé Publique Hôpital de Hautepierre [Strasbourg] Service d’Hépatologie [Hôpital Beaujon]
• Publié dans Cannabis and Cannabinoid Research le 04/10/2021

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Résumé : Background: Chronic hepatitis B virus (HBV) infection may evolve into cirrhosis and hepatocellular carcinoma, and this progression may be accelerated by specific risk factors, including overweight and obesity. Although evidence for a protective effect of cannabis use on elevated body weight has been found for other populations, no data are available for HBV-infected patients. Aims: We aimed to identify risk factors (including cannabis use) for overweight and obesity in patients with HBV chronic infection. Methods: Using baseline data from the French ANRS CO22 Hepather cohort, we performed two separate analyses, one using “central obesity” (based on waist circumference) and the other “overweight” and “obesity” (based on body mass index) as outcomes. Logistic and multinomial regressions were used to model central obesity and overweight/obesity, respectively. Results: Among the 3706 patients in the study population, 50.8% had central obesity, 34.7% overweight, and 14.4% obesity. After multivariable adjustment, current cannabis use was associated with a 59% lower risk of central obesity compared with no lifetime use (adjusted odds ratio [95% CI]: 0.41 [0.24 to 0.70]). It was also associated with a 54% and 84% lower risk of overweight (adjusted relative risk ratio [95% CI]: 0.46 [0.27 to 0.76]) and obesity (0.16 [0.04 to 0.67]), respectively. Conclusions: Cannabis use was associated with lower risks of overweight and obesity in patients with HBV chronic infection. Future studies should test whether these potential benefits of cannabis and cannabinoid use translate into reduced liver disease progression in this high-risk population.

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Fichiers liés : hal-03417059.pdf

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